Patents by Inventor Carmen Almansa Rosales

Carmen Almansa Rosales has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PIPERAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20190276415
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 30, 2019
    Publication date: September 12, 2019
    Inventors: Félix CUEVAS-CORDOBÉS, Carmen ALMANSA-ROSALES, Monica GARCIA-LOPEZ
  • Spiro-isoquinoline-1,4?-piperidine compounds having multimodal activity against pain
    Patent number: 10407428
    Abstract: The present invention relates to spiro-isoquinoline-1,4?-piperidine compounds having dual pharmacological activity towards both the sigma (?) receptor and the ?-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: September 10, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Monica Garcia Lopez, Ana-Maria Caamano-Moure
  • TETRAHYDROPYRAN AND THIOPYRAN DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20190241544
    Abstract: The present invention relates to tetrahydropyran and thiopyran derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 19, 2017
    Publication date: August 8, 2019
    Inventors: Monica GARCIA-LOPEZ, Carmen ALMANSA-ROSALES, Ana Virginia LLORENTE-FERNANDEZ, Ute CHRISTMANN, Sergio RODRIGUEZ ESCRICH
  • Piperazine derivatives having multimodal activity against pain
    Patent number: 10351535
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 16, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Félix Cuevas-Cordobés, Carmen Almansa-Rosales, Monica Garcia Lopez
  • Amide derivatives having multimodal activity against pain
    Patent number: 10351549
    Abstract: The present invention relates to amide derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: July 16, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Monica Garcia-Lopez, Carmen Almansa-Rosales
  • Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Publication number: 20190177337
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: February 14, 2019
    Publication date: June 13, 2019
    Inventors: Marina VIRGILI-BERNADO, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Monica Garcia-Lopez
  • TETRAHYDROPYRIMIDODIAZEPINE AND DIHYDROPYRIDODIAZEPINE COMPOUNDS FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20190144455
    Abstract: The present invention relates to new compounds of general formula (I) that show great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially ?2?-1 subunit of voltage-gated calcium channels or dual activity towards subunit ?2? of voltage-gated calcium channels (VGCC), especially ?2?-1 subunit of voltage-gated calcium channels, and noradrenaline transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: May 5, 2017
    Publication date: May 16, 2019
    Inventors: Félix CUEVAS-CORDOBÉS, Carmen ALMANSA-ROSALES
  • ARYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20190127357
    Abstract: The present invention relates to arylamide derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: April 12, 2017
    Publication date: May 2, 2019
    Inventors: Pilar GOYA, Antoni TORRENS-JOVER, Carmen ALMANSA-ROSALES, Joser-Luis DIAZ-FERNÁNDEZ, Ana-Maria CAAMAÑO-MOURE
  • Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10246465
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: April 2, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Monica Garcia Lopez
  • PIPERIDINYLALKYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20190055217
    Abstract: The present invention relates to piperidinylalkylamide derivatives having dual pharmacological activity towards both the sigma (?) receptor and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: April 12, 2017
    Publication date: February 21, 2019
    Inventors: Antoni TORRENS-JOVER, Nadine JAGEROVIC, Carmen ALMANSA-ROSALES
  • 3-ETHYL-3-PHENYLAZEPANE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20190031615
    Abstract: The present invention relates to 3-ethyl-3-phenylazepane derivatives having dual pharmacological activity towards both the sigma (?) receptor and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 31, 2019
    Inventors: Ramón MERCE-VIDAL, Carmen ALMANSA-ROSALES, Monica GARCIA-LOPEZ
  • 1-methylpyrazole-piperazine compounds having multimodal activity against pain
    Patent number: 10189828
    Abstract: The present invention relates to 1-methylpyrazole-piperazine compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: January 29, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Carmen Almansa-Rosales, Monica Garcia-Lopez, Lourdes Garriga-Sanahuja, Ana Virginia Llorente-Fernandez
  • Oxa-azaspiro compounds having activity against pain
    Patent number: 10183918
    Abstract: The present invention relates to oxa-azaspiro compounds having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: January 22, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Carmen Almansa-Rosales, Carlos Alegret-Molina
  • SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20190002443
    Abstract: The present invention relates to substituted amide derivatives having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: July 28, 2016
    Publication date: January 3, 2019
    Inventors: Monica GARCIA-LOPEZ, Carmen ALMANSA-ROSALES, Ana Virginia LLORENTE-FERNANDEZ, Lourdes GARRIGA-SANAHUJA, Ule CHRISTMANN
  • OXA-DIAZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN
    Publication number: 20190002475
    Abstract: The present invention relates to oxa-diazaspiro compounds having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 21, 2016
    Publication date: January 3, 2019
    Inventors: Marina VIRGILI-BERNADO, Carmen ALMANSA-ROSALES, Carlos ALEGRET-MOLINA
  • OXADIAZASPIRO COMPOUNDS FOR THE TREATMENT OF DRUG ABUSE AND ADDICTION
    Publication number: 20180327422
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.
    Type: Application
    Filed: November 15, 2016
    Publication date: November 15, 2018
    Inventors: Marina VIRGILI-BERNADO, Carmen ALMANSA-ROSALES, Carlos ALEGRET-MOLINA
  • OXA-AZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN
    Publication number: 20180312479
    Abstract: The present invention relates to oxa-azaspiro compounds having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 21, 2016
    Publication date: November 1, 2018
    Inventors: Carmen ALMANSA-ROSALES, Carlos ALEGRET-MOLINA
  • Methyl-1H-pyrazole alkylamine compounds having multimodal activity against pain
    Patent number: 10071968
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to methyl-1H-pyrazole alkylamine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: September 11, 2018
    Assignee: ESTEVE PHARMACEUTICALS S.A.
    Inventors: Antoni Torrens-Jover, Josep Mas-Prio, Carmen Almansa-Rosales, Monica Garcia-Lopez
  • Spiro-isoquinoline-3,4?-piperidine compounds having activity against pain
    Patent number: 10072008
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to spiro-isoquinoline-3,4?-piperidine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: September 11, 2018
    Assignee: ESTEVE PHARMACEUTICALS S.A.
    Inventor: Carmen Almansa-Rosales
  • 1-(4-(2-((1-(3,4-DIFLUOROPHENYL)-1H-PYRAZOL-3-YL)METHOXY)ETHYL)PIPERAZIN-1-YL)ETHANONE SALTS
    Publication number: 20180251430
    Abstract: The present invention relates to 1-(4-(2-((1-(3,4-difluorophenyl)-1 H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone salts, specifically to the hydrochloride and to the maleate, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of sigma receptor associated diseases.
    Type: Application
    Filed: September 1, 2016
    Publication date: September 6, 2018
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Antoni Torrens-Jover, Carmen Almansa Rosales