Abstract: The present invention provides compounds of Formula (I), as selective S1P1 inhibitors, as well as their use for treating multiple sclerosis and other diseases.

Abstract: A method for a multiple port host to communicate with multiple tape drives is provided by requesting information associated with a particular tape. Information is provided that is indicative of availability status of a plurality of host ports. It is determined if there is a traffic load or a reservation load on an active host port. The active host port is reserved if there is not a traffic load or a reservation load on the active host port. Another method receives input indicative of read/write information from at least one tape drive at a host bus adapter. A host port count is increased, and a size of the read/write information is increased until the read/write information is not accepted by the host bus adapter. The host port count is decreased, and the size of the read/write information is decreased until the read/write information is accepted.

Abstract: Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3 and A are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: Pyrazole compounds that are modulators of LRRK2, methods of making the compounds, and methods for using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: A reference measurement apparatus for a multiphase flow meter comprising: a sampling and measuring chamber coupled to a sampling port via a sample transfer line for extracting the sample having at least one of the gas phase and the liquid phase from the multiphase fluid mixture flowing through the pipe section; a pressure and temperature regulation arrangement arranged to maintain the sample from the sampling port to the sampling and measuring chamber at a pressure/temperature substantially similar to the pressure/temperature of the multiphase fluid mixture flowing through the pipe section; and a second fraction measurement device arranged to estimate a linear attenuation related to the at least one of the gas phase and the liquid phase extracted from the sample, said linear attenuation being used to correct the estimated representative fraction for the at least one of the gas phase and the liquid phase of the multiphase fluid mixture.

Abstract: Both a flow meter system and method are provided for accurately measuring the percentage amounts of liquid and gas phases in a multiphase flow through a conduit when the liquid phase constitutes a small minority portion (e.g., less than about 20%) of the multiphase flow. The system includes a flow meter that includes a differential pressure sensor connected across a Venturi in the conduit, and a dual energy fraction meter, each of which is operably connected to a digital processor. The system further includes a pump connected to the conduit upstream of the flow meter that introduces at least one pulse of a known quantity of liquid, the pulse being sufficient in volume to temporarily increase the liquid phase by a detectable amount.

Abstract: What is presented is an ultrasonic waveguide for the transmission of ultrasonic vibrations that establishes a plurality of node and anti-node positions that are each along the ultrasonic waveguide's central axis. The ultrasonic waveguide comprises a waveguide tube, which has both a proximal end and a distal end; a waveguide fitting, which has both a threaded end and a impact surface; and a spring, shock-pulsing mass, and stop. Both the spring and shock-pulsing mass are each positioned on the waveguide tube. Whereas, the stop is positioned on the waveguide tube and it is adapted to non-fixedly engage the spring and shock-pulsing mass. The impact surface of the waveguide fitting is located at an anti-node position, which is along the central axis of the ultra-sonic waveguide when its installed within ultrasonic transducer while in operation.

Abstract: A multiple port host communicates with multiple tape drives by requesting information associated with a particular tape. Information of availability status of a plurality of host ports is provided. Traversing all host initiator ports finds a host port with no or the least traffic load for a tape reservation request. A host port's traffic load calculation uses instant and the updated historical traffic as primary and secondary factors. Every host port's traffic load is updated for every read/write command, and is used for path selection of reservation requests. The instant load is relatively sensitive but will be zero under light load. The historical load is aware of the light load though it is not sensitive enough when a burst I/O occurs. With the traffic load calculated from instant and historical loads, the distribution of tape tasks is spread evenly among host initiator ports under light load and burst I/O scenarios.

Abstract: A toilet brush having a handle grip connected to a pull rod which is adapted to travel freely through a hollow main handle. The pull rod is connected at the other end to a cleaning head assembly, having stiff bristles and an absorbent sponge. The sponge is modified to include a scouring surface. The cleaning head assembly is modified to allow any moisture collected by the absorbent sponge to be extracted by pulling on the hollow main handle and the coil spring placing the hollow main handle back to its original position.

Abstract: A multiple port host communicates with multiple tape drives by requesting information associated with a particular tape. Information of availability status of a plurality of host ports is provided. Traversing all host initiator ports finds a host port with no or the least traffic load for a tape reservation request. A host port's traffic load calculation uses instant and the updated historical traffic as primary and secondary factors. Every host port's traffic load is updated for every read/write command, and is used for path selection of reservation requests. The instant load is relatively sensitive but will be zero under light load. The historical load is aware of the light load though it is not sensitive enough when a burst I/O occurs. With the traffic load calculated from instant and historical loads, the distribution of tape tasks is spread evenly among host initiator ports under light load and burst I/O scenarios.

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: Specific Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein m, X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: The present invention relates to pyrazole oxadiazoles derivatives of Formula (I), and their use for treating multiple sclerosis and other diseases, wherein R1, R2 and R3 are as defined in the description.

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: A multiple port host communicates with multiple tape drives by requesting information associated with a particular tape. Information of availability status of a plurality of host ports is provided. Traversing all host initiator ports finds a host port with no or the least traffic load for a tape reservation request. A host port's traffic load calculation uses instant and the updated historical traffic as primary and secondary factors. Every host port's traffic load is updated for every read/write command, and is used for path selection of reservation requests. The instant load is relatively sensitive but will be zero under light load. The historical load is aware of the light load though it is not sensitive enough when a burst I/O occurs. With the traffic load calculated from instant and historical loads, the distribution of tape tasks is spread evenly among host initiator ports under light load and burst I/O scenarios.

Abstract: Compounds of formula (I) described herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

Abstract: Compounds of formula (I) defined herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract characterized by airway obstruction.

Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.