Abstract: A flow meter apparatus and method are presented for measuring a flow rate of a multiphase fluid mixture comprising at least one gas phase and one liquid phase. The flow meter comprises a pipe section and measurement section through which the mixture flows. The flow meter also comprises a fraction measurement device adapted to estimate a representative fraction of the gas phase and/or liquid phase of the mixture passing at the measurement section. Moreover, the flow meter preferably comprises at least one ultrasonic sensor arranged to estimate a characteristic, such as liquid film thickness or velocity, of a portion of the liquid phase flowing as liquid film along a wall of the pipe section.

Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Abstract: An apparatus (1) for measuring at least one characteristic value of a multiphase fluid mixture (13) comprises: a pipe section (20) having a main flow path through which the multiphase fluid mixture (13) flows, the main flow path comprising a throat (22) between an upstream part (21) and a downstream part (23) of the main flow path such as to generate a pressure drop between the upstream part (21) and the downstream part (23); a first sensing arrangement (28, 33, 29, 34, 35, 36) to measure a first characteristic value of the multiphase fluid mixture (13) flowing into the main flow path; -a channel (25) being positioned within the wall of the pipe section (20) such as to maintain similar operating conditions as in the main flow path, the channel (25) being coupled to the main flow path by an inlet (24) at the up-stream part (21), or the throat (22), and by an outlet (26) at the downstream part (23), or the throat (22), such that the pressure drop generates an aspiration effect diverting a sample of the multipha

Abstract: A method for a multiple port host to communicate with multiple tape drives is provided by requesting information associated with a particular tape. Information is provided that is indicative of availability status of a plurality of host ports. It is determined if there is a traffic load or a reservation load on an active host port. The active host port is reserved if there is not a traffic load or a reservation load on the active host port. Another method receives input indicative of read/write information from at least one tape drive at a host bus adapter. A host port count is increased, and a size of the read/write information is increased until the read/write information is not accepted by the host bus adapter. The host port count is decreased, and the size of the read/write information is decreased until the read/write information is accepted.

Abstract: A multiple port host communicates with multiple tape drives by requesting information associated with a particular tape. Information of availability status of a plurality of host ports is provided. Traversing all host initiator ports finds a host port with no or the least traffic load for a tape reservation request. A host port's traffic load calculation uses instant and the updated historical traffic as primary and secondary factors. Every host port's traffic load is updated for every read/write command, and is used for path selection of reservation requests. The instant load is relatively sensitive but will be zero under light load. The historical load is aware of the light load though it is not sensitive enough when a burst I/O occurs. With the traffic load calculated from instant and historical loads, the distribution of tape tasks is spread evenly among host initiator ports under light load and burst I/O scenarios.

Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Abstract: The present invention provides compounds of Formula (I), as selective S1P1 inhibitors, as well as their use for treating multiple sclerosis and other diseases.

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: Several implementations of a fan folding mechanism for folding flaps of a case into a fan fold arrangement are disclosed and described. In one implementation, the fan folding mechanism comprises four shoes, arranged to allow one shoe to contact a flap on each of four sides of the case. A finger, carried by each of the four shoes is configured for movement between a retracted position and an extended position, such that in the retracted position, each finger is in contact with a leading corner of a different flap of the case and the flaps are in an open position and in the extended position, each finger is in contact with the same leading corner of the same flap, and the flap is in the closed position. Four suction cups, each configured for releasable attachment to a trailing corner of a flap, may inhibit contention between flaps.

Abstract: The invention provides systems and methods for intra-day trading of actively managed exchange traded funds (AMETFs). The invention provides creation and redemption structures for AMETF shares that allow arbitrage, intra-day value estimations for AMETF shares, and hedging portfolios for hedging risks associated with trading AMETF shares, all without requiring disclosure of the specific assets underlying the AMETF.

Abstract: The invention provides systems and methods for checking portfolios used to model the behavior of actively managed funds to facilitate intra-day trading of actively managed exchange traded funds (AMETFs) without revealing the fund assets. The invention also provides exchange traded notes based on an underlying actively managed fund without revealing the fund assets.

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: The invention relates to compounds of formula I: wherein R1, R2,Ra, Rb, X have the meanings given in claim 16. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.

Abstract: Systems and methods are provided to determine an estimated value of a traded fund whose assets are not publicly disclosed on a daily basis, where a computer system includes one or more computers and is programmed to determine an estimated value of the traded fund. Embodiments include operating the computer system to calculate an estimated value of the traded fund based on the value of a proxy portfolio, where the identities of the assets of the traded fund are not disclosed to an investor who trades shares of the traded fund on a secondary market, and publicly disclosing the estimated value of the traded fund periodically throughout a trading day.

Abstract: System and methods for checking portfolios used to model the behavior of actively managed funds to facilitate intra-day trading of actively managed exchange traded funds (AMETFs) without revealing the fund assets. Exchange traded notes based on an underlying actively managed fund without revealing the fund assets. Computer means are used to perform a statistical comparison between a model portfolio and the AMETF, and a statistical comparison compares the periodic values, returns, or risk characteristics of the model portfolio and the financial instrument over some period of time, periodically sending or publishing the results of the statistical comparison. The model portfolio does not reveal the assets of the financial instrument.

Abstract: The present invention relates to pyrazole oxadiazoles derivatives of Formula (I), and their use for treating multiple sclerosis and other diseases, wherein R1, R2 and R3 are as defined in the description.

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Abstract: A system for pricing and/or determining a basket of financial instruments for hedging investment risk in actively managed traded funds is described. The system uses a trusted computer system and includes a computer storage medium storing a computer program product. The product determines a basket of hedging instruments by applying statistical or economic based factor analysis to estimate the NAV or provide a hedging basket to rack actual NAV of an actively managed traded fund.

Abstract: A method of determining an estimate of the market value of a traded unit of a financial instrument, and apparatus for carrying out the method, said instrument comprising a fund of individually priced securities and the exact composition of said fund being withheld from the market, said method comprising selecting a plurality of mutually independent risk factors, each risk factor being representative of market behaviour estimated to be significant to the price behaviour of the traded unit, obtaining information from a third party holding information regarding the composition of said fund regarding the actual significance of said risk factors to the value of said traded unit, and calculating a value for said traded unit on the basis of said significances.

Abstract: More efficient systems and methods for processing mutual fund transactions are provided by a centralized settlement and record-keeping repository for mutual fund shares. These systems and methods result in significant enhancements and cost savings to the mutual fund industry.