Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.

Abstract: An atomization core includes: a substrate; and a heating element in contact with the substrate, the heating element including SS316L heating wires and two electrode connecting portions. The SS316L heating wires heat an aerosol generation substrate. The two electrode connecting portions are electrically connectable to a power supply. The two electrode connecting portions are arranged at an interval. The SS316L heating wires are bent and extend to be connected to the two electrode connecting portions.

Abstract: A Hall sensor fixing member, used for fixing a Hall sensor to a metal piece. A mounting hole into which the Hall sensor fixing member is inserted is formed in the Hall sensor. The Hall sensor fixing member is made of an elastic material. A through hole into which the metal piece is inserted is axially formed in the interior of the Hall sensor fixing member. The size of the through hole is less than the size of the metal piece. When the metal piece is inserted into the through hole by squeezing, the Hall sensor fixing member is elastically deformed and expands outward under the action of squeezing by the metal piece, such that the outer wall of the Hall sensor fixing member and the inner wall of the mounting hole of the Hall sensor abut against to each other and are thus fixed.

Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.

Abstract: A battery case includes a case body, a first baffle plate and a baffle cover. A gas exhaust channel is obliquely penetrated through a wall of the case body. The first baffle plate and the baffle cover are connected to the outer surface of the wall of the case body. The gas exhaust channel includes a gas inlet and a gas outlet. The first baffle plate is located on one side of the gas outlet away from the gas inlet. The baffle cover covers the gas outlet and the first baffle plate. There is a gas passage between the inner surface of the baffle cover and the first baffle plate. The baffle cover is provided with a gas exhaust opening. The gas inside the case body can be discharged out from the gas exhaust opening after flowing sequentially through the gas exhaust channel and the gas passage.

Abstract: Disclosed are small molecule antagonists of ?4?7 integrin, and methods of using them to treat a number of specific diseases or conditions.

Abstract: A battery module includes a battery cell assembly and a fire extinguishing member. The battery cell assembly includes a plurality of battery cell frames and a plurality of battery cells. The plurality of the battery cell frames are arranged sequentially along a length direction of the battery module. At least one battery cell is provided in at least some of the battery cell frames. Each battery cell frame is provided with a fire extinguishing slot, and the fire extinguishing slots on the plurality of the battery cell frames are communicated to each other to form a fire extinguishing channel. The fire extinguishing member is arranged in the fire extinguishing channel. The fire extinguishing channel extends along the length direction of the battery module, and the fire extinguishing member extends along the length direction of the battery module in the fire extinguishing channel.

Abstract: Provided are a data search processing method and apparatus, an electronic device, and a storage medium. The method includes: receiving a search request that includes an entity keyword attributing to a target category; acquiring dimension information on the target category in at least two dimensions and a multimedia resource set of the entity keyword in each of the at least two dimensions, in which the at least two dimensions includes an entity making dimension and an entity site dimension; and displaying a search result page, in which the search result page includes a first region and a second region, the dimension information in the at least two dimensions is displayed in the first region, the second region including a plurality of predetermined sub-regions, and the multimedia resource set in corresponding one of the at least two dimensions to each predetermined sub-region is displayed in the predetermined sub-region.

Abstract: Disclosed are small molecule antagonists of human ?4?7 integrin, and methods of using them to treat a number of diseases and conditions.

Abstract: In implementations of systems for estimating temporal occurrence of a binary state change, a computing device implements an occurrence system to compute a posterior probability distribution for temporal occurrences of binary state changes associated with client computing devices included in a group of client computing devices. The occurrence system determines probabilities of a binary state change associated with a client computing device included in the group of client computing devices based on the posterior probability distribution, and the probabilities correspond to future periods of time. A future period of time is identified based on a probability of the binary state change associated with the client computing device. The occurrence system generates a communication based on a communications protocol for transmission to the client computing device via a network at a period of time that correspond to the future period of time.

Abstract: A parallel multi-step bio-reaction system(10) comprising: (a) a substrate arrangement(12) comprising a plurality of bio-reaction substrate holders(18) configured to hold a plurality of bio-reaction substrates(20); (b) a well arrangement(14) comprising a plurality of fluidic wells(22), the fluidic wells(22) corresponding to a plurality of steps of a multi-step bio-reaction; (c) an actuator(16) configured to: (i) move either the substrate arrangement(12) or the well arrangement(14) relative to the other of the substrate arrangement(12) or the well arrangement(14) to change the alignment of the bio-reaction substrates(20) as a group relative to the fluidic wells(22) as a group; and (ii) bring the bio-reaction substrates(20) into and out of contact with fluids in the fluidic wells(22).

Abstract: Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample.

Abstract: Present invention is related to a polyimide of formula as following: and a ketone-containing alicyclic dianhydride of formula as following: wherein: R1, R2, R3, R4 denote hydrogen atom or carbon containing functional group with carbon number at a range of 1-4; R5 denotes diamine group; and n equals to any positive integer.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.

Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.

Abstract: Disclosed are small molecule inhibitors of ?v?6 integrin, and methods of using them to treat a number of diseases and conditions.