Patents by Inventor Chengzhi Zhang

Chengzhi Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Patent number: 7358386
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: April 15, 2008
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
    Patent number: 7351735
    Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: April 1, 2008
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Jianmei Fan, Holia Hatoum-Mokdad, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips
  • Novel Pyrimidothienoindazoles
    Publication number: 20070299066
    Abstract: The invention relates to novel pyrimidothienoindazoles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Application
    Filed: October 26, 2005
    Publication date: December 27, 2007
    Applicant: Bayer Phamaceuticals Corporation
    Inventors: Chengzhi Zhang, Roger Smith, Gan Wang, Sharad Verma, Qingming Zhu
  • Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders
    Patent number: 7238701
    Abstract: The present invention relates to a compound of Formula (I) and its use in treating lung and breast cancer.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: July 3, 2007
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Gaetan H. Ladouceur, Catherine Brennan, Brent Chandler, Julie A. Dixon, Karl Miranda, Dongping Fan, Qingming Zhu, Sharad Verma, Jacques Dumas
  • Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders
    Publication number: 20060293322
    Abstract: The present invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
    Type: Application
    Filed: July 23, 2004
    Publication date: December 28, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Gaetan Ladouceur, Catherine Brennan, Brent Chandler, Julie Dizon, Karl Miranda, Dongping Fan, Qingming Zhu, Sharad Verma, Jacques Dumas
  • Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
    Publication number: 20060287387
    Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
    Type: Application
    Filed: August 28, 2006
    Publication date: December 21, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott Wilhelm, Qian Zhao
  • Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
    Patent number: 7144885
    Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: December 5, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott M. Wilhelm, Qian Zhao
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Patent number: 7112597
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: September 26, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Publication number: 20060205723
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Application
    Filed: May 5, 2006
    Publication date: September 14, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Derek Lowe, Philip Wickens, Xin Ma, Mingbao Zhang, William Bullock, Philip Coish, Ingo Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James Livingston
  • Benzofuran derivatives useful for treating hyper-proliferative disorders
    Publication number: 20060194816
    Abstract: The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Application
    Filed: August 6, 2004
    Publication date: August 31, 2006
    Applicant: Baer Phamaceuticals Corporation
    Inventor: Chengzhi Zhang
  • Furopyridine and furopyrimidine derivatives for the treatment of hyper-proliferative disorders
    Publication number: 20060040960
    Abstract: This invention relates to a compound of Formula (I) wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy halo, OH, CF3, CN, NO2 and (C1-C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each option-ally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorders.
    Type: Application
    Filed: July 11, 2003
    Publication date: February 23, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Gaetan Ladouceur, Michael Burke
  • Fused tricyclic heterocycles useful for treating hyper-proliferative disoroders
    Publication number: 20050165042
    Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders.
    Type: Application
    Filed: February 21, 2003
    Publication date: July 28, 2005
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott Wilheim, Qian Zhao
  • Benzofuran and benzothiophene derivatives useful in the treatmint of hyper-proliferative disorders
    Publication number: 20050139814
    Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders.
    Type: Application
    Filed: February 21, 2003
    Publication date: June 30, 2005
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Jianmei Fan, Holia Hatoum-Mokdad, Benjamin Jones, Gaetan Ladouceur, Wendy Lee, Barton Philiips
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Publication number: 20050075338
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Application
    Filed: September 22, 2004
    Publication date: April 7, 2005
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Derek Lowe, Philip Wickens, Xin Ma, Mingbao Zhang, William Bullock, Philip Coish, Ingo Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James Livingston
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Patent number: 6828335
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: December 7, 2004
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo A. Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • Substituted 3-pyridyl imidazoles as c17,20 lyase inhibitors
    Publication number: 20040209924
    Abstract: This invention provides 3-pyridyl imidazoles, pharmaceutical compositions containing them, and methods of using these for treatment of cancer.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 21, 2004
    Inventors: Barry Hart, Donald E Bierer, Jacques Dumas, Robert Sibley, Chengzhi Zhang
  • Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors
    Publication number: 20040198773
    Abstract: Substituted 3-pyridyl oxazoles which inhibit C17, 20 Lyase, pharmaceutical preparations containing them, and methods of using them in treatment of cancer arc provided.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 7, 2004
    Inventors: Barry Hart, Donald E Bierer, Chengzhi Zhang
  • Pyrazole derivatives useful in the treatment of hyper-proliferative disorders
    Publication number: 20040180891
    Abstract: This invention relates to pyrazole derivatives of 1
    Type: Application
    Filed: March 15, 2004
    Publication date: September 16, 2004
    Inventors: Uday Khire, Chengzhi Zhang, Harold C E Kluender, Ingo Mugge, Zhengqui Hong, Jianxing Shao, Neil Bifulco, Pamela A Trail, Jacques Dumas, Rico C Lavoie, Xaio-Gao Liu, Veena Agarwal, Sharad K Verma, Lei Wang
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Publication number: 20030216391
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Application
    Filed: July 25, 2002
    Publication date: November 20, 2003
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D.G. Coish, Ingo A. Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • Naphthalenedione nitric oxide synthase (NOS) inhibitors
    Patent number: 5866569
    Abstract: There are disclosed methods useful for the inhibition of inducible nitric oxide synthase by the adminstration of a compound of the formula I:. when R.sub.2 is H then R.sub.1 is selected from the group consisting of:1) aryl,--NH--C.sub.0 -C.sub.10 alkyl -aryl, N-(C.sub.0 -C.sub.10 alkyl substituted aryl).sub.2, --C.sub.0 -C.sub.10 alkyl substituted aryl, --N(C.sub.0 -C.sub.10 alkyl substituted aryl)(C.sub.0 -C.sub.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: February 2, 1999
    Assignee: Ontogen Corporation
    Inventors: Adnan M. M. Mjalli, Sepehar Sarshar, Chengzhi Zhang