Patents by Inventor Chengzhi Zhang

Chengzhi Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRIMIDINONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
    Publication number: 20140107135
    Abstract: The present invention relates to new pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 16, 2013
    Publication date: April 17, 2014
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2
    Patent number: 8637524
    Abstract: The present invention relates to new pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: January 28, 2014
    Assignee: Auspex Pharmaceuticals, Inc
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • SUBSTITUTED N-ARYL PYRIDONES
    Publication number: 20130345264
    Abstract: Disclosed herein are methods of administering deuterated pirfenidone and kits thereof.
    Type: Application
    Filed: March 6, 2012
    Publication date: December 26, 2013
    Inventor: Chengzhi Zhang
  • PEGYLATED CYCLOPAMINE ANALOGUE, PREPARATION METHOD AND USES THEREOF
    Publication number: 20130324569
    Abstract: A PEGylated cyclopamine analog, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analog is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates.
    Type: Application
    Filed: February 25, 2011
    Publication date: December 5, 2013
    Applicant: Beijing Kemedicine Co., Ltd.
    Inventors: Chun Song, Chengzhi Zhang, Xin Zhao, Zhao Hu, Xiuling Xu, Youzhong Zhang, Mingyi Wang, Zhijun Sun
  • Aminothiazole modulators of beta-3-adrenoreceptor
    Patent number: 8586760
    Abstract: The present invention relates to new aminothiazole modulators of beta-3-adrenoreceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: November 19, 2013
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Quinolone inhibitors of lipoprotein-associated phospholipase A2
    Patent number: 8575348
    Abstract: The present invention relates to new quinolone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: November 5, 2013
    Assignee: Auspex Pharmaceuticals, Inc
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • AMINOTHIAZOLE MODULATORS OF BETA-3-ADRENORECEPTOR
    Publication number: 20130281498
    Abstract: The present invention relates to new aminothiazole modulators of beta-3-adrenoreceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: June 19, 2013
    Publication date: October 24, 2013
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Patent number: 8552203
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: October 8, 2013
    Assignee: Bayer Healthcare LLC
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo A. Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Patent number: 8541618
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: September 24, 2013
    Assignee: Bayer HealthCare LLC
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo A. Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • Tetrahydropyridothienopyrimidine compounds and methods of use thereof
    Patent number: 8501755
    Abstract: This invention relates to compounds of Formula (I), wherein the variables are as disclosed in the specification, to pharmaceutical compositions containing them, to methods of making the compounds and pharmaceutical compositions, and to methods of using the compounds and pharmaceutical compositions for treating or preventing disorders, in particular cancer.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: August 6, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Chengzhi Zhang, Kanwar Sidhu, Mario Lobell, Gaetan Ladouceur, Qian Zhao, Zheng Liu, Kristen M. Allegue, Chetan P. Darne, Jason Newcom
  • CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR
    Publication number: 20120301458
    Abstract: The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Application
    Filed: July 27, 2010
    Publication date: November 29, 2012
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Piperidine inhibitors of Janus kinase 3
    Patent number: 8299084
    Abstract: The present invention relates to new piperidine inhibitors of Janus kinase 3 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: October 30, 2012
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Pyrimidinothienoindazoles useful for the treatment of hyperproliferative disorders
    Patent number: 8207172
    Abstract: The invention relates to novel heterocycles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: June 26, 2012
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Chengzhi Zhang, Jacques Dumas, Qingming Zhu, Roger Smith, Qingjie Liu, Sharad Verma, Jason Duquette, Qian Zhao, Dongping Fan, Georgiy Bondar, Philip Coish
  • Compounds and compositions as protein kinase inhibitors
    Patent number: 8202876
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: June 19, 2012
    Assignees: IRM LLC, Novartis AG
    Inventors: Pamela Albaugh, Gregory B. Chopiuk, Qiang Ding, Shenlin Huang, Zuosheng Liu, Shifeng Pan, Pingda Ren, Xia Wang, Xing Wang, Yongping Xie, Chengzhi Zhang, Qiong Zhang, Guobao Zhang, Daniel Poon, Paul Renhowe, Martin Sendzik
  • BENZOQUINOLONE INHIBITORS OF VMAT2
    Publication number: 20120003330
    Abstract: The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: May 31, 2011
    Publication date: January 5, 2012
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Thomas G. Gant, Chengzhi Zhang, Manoucherhr Shahbaz
  • PYRIMIDINONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
    Publication number: 20110306552
    Abstract: The present invention relates to new pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Application
    Filed: July 21, 2010
    Publication date: December 15, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • BENZAZEPINE INHIBITORS OF GAMMA-SECRETASE
    Publication number: 20110306596
    Abstract: The present invention relates to new benzazepine inhibitors of gamma-secretase activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 19, 2010
    Publication date: December 15, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • 3,4-METHYLENEDIOXYPHENYL INHIBITORS OF GABA AMINOTRANSFERASE AND/OR GABA REUPTAKE TRANSPORTER INHIBITOR
    Publication number: 20110257260
    Abstract: The present invention relates to new 3,4-methylenedioxyphenyl inhibitors of GABA aminotransferase activity and/or GABA reuptake transporter activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 20, 2010
    Publication date: October 20, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • PIPERIDINE MODULATORS OF DOPAMINE RECEPTOR
    Publication number: 20110206782
    Abstract: The present invention relates to new piperidine modulators of dopamine receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: February 15, 2011
    Publication date: August 25, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Chengzhi Zhang
  • MORPHINAN MODULATORS OF NMDA RECEPTORS, SIGMA1 RECEPTORS, SIGMA2 RECEPTORS, AND/OR A3B4 NICOTINIC RECEPTORS
    Publication number: 20110206780
    Abstract: The present invention relates to new morphinan modulators of NMDA receptors, ?1 receptors, ?2 receptors, and/or ?3?4 nicotinic receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: January 5, 2011
    Publication date: August 25, 2011
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar, Chengzhi Zhang