Patents by Inventor Chengzhi Zhang

Chengzhi Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR
    Publication number: 20100286275
    Abstract: The present invention relates to new biphenyl-3-carboxylic acid modulators of beta-3-adrenoceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 9, 2010
    Publication date: November 11, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Chengzhi Zhang
  • BENZIMIDAZOLE MODULATORS OF H1 RECEPTOR AND/OR NS4B PROTEIN
    Publication number: 20100284970
    Abstract: The present invention relates to new benzimidazole modulators of H1 receptor activity and/or inhibitors of NS4B protein activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 9, 2010
    Publication date: November 11, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Benzofuran derivatives useful for treating hyper-proliferative disorders
    Patent number: 7803956
    Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: September 28, 2010
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan H. Ladouceur, Qian Zhao, Martin F. Hentemann, Sharad K. Verma, Qingming Zhu, Rico C. Lavoie, Jianmei Fan, Barton Phillips
  • Heterocycles
    Patent number: 7750017
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly hyperproliferative diseases such as cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly hyperproliferative diseases such as cancer.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: July 6, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Chengzhi Zhang, Roger Smith, Jason Duquette, Qian Zhao, Jacques Dumas, Georgiy Bondar, Yingfu Li, Dongping Fan
  • ARYLPIPERAZINE MODULATORS OF D2 RECEPTORS, 5-HT1A RECEPTORS, AND/OR 5-HT2A RECEPTORS
    Publication number: 20100069399
    Abstract: The present invention relates to new arylpiperazine modulators of D2 receptors, 5-HT1A receptors, and/or 5-HT2A receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: February 27, 2009
    Publication date: March 18, 2010
    Applicant: AUSPEX PHARMACEUTICAL, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar, Chengzhi Zhang
  • Benzofuran derivatives useful for treating hyper-proliferative disorders
    Patent number: 7659412
    Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: February 9, 2010
    Assignee: Bayer Healthcare LLC
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan Ladouceur, Qian Zhao, Martin Hentemann, Sharad Verma, Qingming Zhu, Rico Lavoie, Jianmei Fan, Barton Phillips
  • COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
    Publication number: 20100029605
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.
    Type: Application
    Filed: September 24, 2007
    Publication date: February 4, 2010
    Applicants: Novartis AG
    Inventors: Pamela Albaugh, Gregory S. Chopiuk, Qiang Ding, Shenlin Huang, Zuosheng Liu, Shifeng Pan, Pingda Ren, Xia Wang, Xing Wang, yongping Xie, Chengzhi Zhang, Qiong Zhang, Guobao Zhang, Daniel Poon, Paul Renhowe, Martin Sendzik
  • BENZOFURAN DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS
    Publication number: 20090292014
    Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders
    Type: Application
    Filed: May 22, 2009
    Publication date: November 26, 2009
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan H. Ladouceur, Qian Zhao, Martin F. Hentemann, Sharad K. Verma, Qingming Zhu, Rico C. Lavoie, Jianmei Fan, Barton Phillips
  • Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
    Patent number: 7585888
    Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: September 8, 2009
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael J. Burke, Zhi Chen, Jacques P. Dumas, Dongping Fan, Jianmei Fan, Holia Hatoum-Mokdad, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips
  • NOVEL PYRIMIDOTHIENOINDAZOLES
    Publication number: 20090186887
    Abstract: The invention relates to novel pyrimidothienoindazoles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Application
    Filed: March 30, 2009
    Publication date: July 23, 2009
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Roger A. Smith, Gan Wang, Sharad K. Verma, Qingming Zhu
  • FUROPYRIDINE AND FUROPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS
    Publication number: 20090143412
    Abstract: This invention relates to a compound of Formula I wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy, halo, OH, CF3, CN, NO2 and (C1-C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorder.
    Type: Application
    Filed: September 26, 2008
    Publication date: June 4, 2009
    Applicant: Bayer HealthCare LLC
    Inventors: Chengzhi Zhang, Gaetan Ladouceur, Michael J. Burke
  • Pyrimidothienoindazoles
    Patent number: 7511048
    Abstract: The invention relates to novel pyrimidothienoindazoles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: March 31, 2009
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Roger Smith, Gan Wang, Sharad Verma, Qingming Zhu
  • BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS
    Publication number: 20090054514
    Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.
    Type: Application
    Filed: March 31, 2008
    Publication date: February 26, 2009
    Inventors: Chengzhi ZHANG, Michael BURKE, Zhi CHEN, Jacques DUMAS, Dongping FAN, Jianmei FAN, Holia HATOUM-MOKDAD, Benjamin JONES, Gaetan LADOUCEUR, Wendy LEE, Barton PHILLIPS
  • Indane Acetic Acid Derivatives and Their Use as Pharmaceutical Agents, Intermediates, and Method of Preparation
    Publication number: 20090047687
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Application
    Filed: March 31, 2008
    Publication date: February 19, 2009
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo A. Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • SUBSTITUTED CYCLOHEXENES
    Publication number: 20090022706
    Abstract: Disclosed herein are substituted cyclohexene TLR4 signaling pathway modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 18, 2008
    Publication date: January 22, 2009
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Thomas G. Gant, Sepehr Sarshar, Chengzhi Zhang
  • BENZOFURAN DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS
    Publication number: 20090023783
    Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders
    Type: Application
    Filed: August 29, 2008
    Publication date: January 22, 2009
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan H. Ladouceur, Qian Zhao, Martin Hentemann, Sharad K. Verma, Qingming Zhu, Rico C. Lavoie, Jianmei Fan, Barton Phillips
  • Furo[2.3-b]pyridine derivatives for the treatment of hyper-proliferative disorders
    Patent number: 7429584
    Abstract: This invention relates to a compound of Formula (I) wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy halo, OH, CF3, CN, NO2 and (C1-C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorders.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: September 30, 2008
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Gaetan Ladouceur, Michael J. Burke
  • Benzofuran derivatives useful for treating hyper-proliferative disorders
    Patent number: 7420066
    Abstract: The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: September 2, 2008
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan H. Ladouceur, Qian Zhao, Martin F. Hentemann, Sharad K. Verma, Qingming Zhu, Rico C. Lavoie, Jianmei Fan, Barton Phillips
  • Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
    Patent number: 7384947
    Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: June 10, 2008
    Assignee: Bayer HealthCare LLC
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott M. Wilhelm, Qian Zhao
  • Novel Heterocycles
    Publication number: 20080132497
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly hyperproliferative diseases such as cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly hyperproliferative diseases such as cancer.
    Type: Application
    Filed: October 14, 2005
    Publication date: June 5, 2008
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Roger Smith, Jason Duquette, Qian Zhao, Jacques Dumas, Georgiy Bondar, Yingfu Li, Dongping Fan