Patents by Inventor Chengzhi Zhang

Chengzhi Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION
    Publication number: 20110152330
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Application
    Filed: February 25, 2011
    Publication date: June 23, 2011
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo A. Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • QUINOLONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
    Publication number: 20110136861
    Abstract: The present invention relates to new quinolone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 28, 2010
    Publication date: June 9, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • CYCLOHEXYL UREA MODULATORS OF D2 RECEPTORS AND/OR D3 RECEPTORS
    Publication number: 20110117214
    Abstract: The present invention relates to new cyclohexyl urea modulators of D2 receptors and/or modulators of D3 receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: November 15, 2010
    Publication date: May 19, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Ronald C. Newbold, Chengzhi Zhang
  • THIADIAZOLE MODULATORS OF BETA ADRENERGIC RECEPTOR
    Publication number: 20110086847
    Abstract: The present invention relates to new thiadiazole modulators of beta adrenergic receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: June 9, 2010
    Publication date: April 14, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • AMINOTHIAZOLE MODULATORS OF BETA-3-ADRENORECEPTOR
    Publication number: 20110081426
    Abstract: The present invention relates to new aminothiazole modulators of beta-3-adrenoreceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: June 9, 2010
    Publication date: April 7, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • SULFONYLUREA MODULATORS OF ENDOTHELIN RECEPTOR
    Publication number: 20110082151
    Abstract: The present invention relates to new sulfonylurea modulators of endothelin receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: June 8, 2010
    Publication date: April 7, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION
    Publication number: 20110065129
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Application
    Filed: February 11, 2009
    Publication date: March 17, 2011
    Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo A. Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston
  • AMINOPYRIMIDINE INHIBITORS OF TYROSINE KINASE
    Publication number: 20110053968
    Abstract: The present invention relates to new aminopyrimidine inhibitors of tyrosine kinase activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Application
    Filed: June 3, 2010
    Publication date: March 3, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Chengzhi Zhang
  • NAPTHYLENE INHIBITORS OF CYCLOOXYGENASE
    Publication number: 20110054020
    Abstract: The present invention relates to new napthylene inhibitors of cyclooxygenase activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Application
    Filed: May 4, 2010
    Publication date: March 3, 2011
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang, Thomas G. Gant, Sepehr Sarshar
  • PYRIMIDOTHIENOINDAZOLES
    Publication number: 20110053928
    Abstract: The invention relates to novel pyrimidothienoindazoles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Application
    Filed: November 3, 2010
    Publication date: March 3, 2011
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Chengzhi Zhang, Roger Smith, Gan Wang, Sharad Verma, Qingming Zhu
  • SULFONAMIDE INHIBITORS OF CARBONIC ANHYDRASE
    Publication number: 20100317655
    Abstract: The present invention relates to new sulfonamide inhibitors of carbonic anhydrase activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: June 4, 2010
    Publication date: December 16, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Tetrahydropyridothienopyrimidine Compounds and Methods of Use Thereof
    Publication number: 20100298297
    Abstract: This invention relates to compounds of Formula (I), wherein the variables are as disclosed in the specification, to pharmaceutical compositions containing them, to methods of making the compounds and pharmaceutical compositions, and to methods of using the compounds and pharmaceutical compositions for treating or preventing disorders, in particular cancer.
    Type: Application
    Filed: March 20, 2007
    Publication date: November 25, 2010
    Applicant: BAYER HEALTHCARE AG
    Inventors: Chengzhi Zhang, Kanwar Sidhu, Mario Lobell, Gaeten Ladouceur, Qian Zhao, Zheng Liu, Kristen Allegue, Chetan Darne, Jason Newcom
  • PIPERIDINE INHIBITORS OF JANUS KINASE 3
    Publication number: 20100291026
    Abstract: The present invention relates to new piperidine inhibitors of Janus kinase 3 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 20, 2010
    Publication date: November 18, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • INDAZOLE INHIBITORS OF TYROSINE KINASE
    Publication number: 20100291025
    Abstract: The present invention relates to new indazole inhibitors of tyrosine kinase activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 13, 2010
    Publication date: November 18, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR
    Publication number: 20100286275
    Abstract: The present invention relates to new biphenyl-3-carboxylic acid modulators of beta-3-adrenoceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 9, 2010
    Publication date: November 11, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventor: Chengzhi Zhang
  • BENZIMIDAZOLE MODULATORS OF H1 RECEPTOR AND/OR NS4B PROTEIN
    Publication number: 20100284970
    Abstract: The present invention relates to new benzimidazole modulators of H1 receptor activity and/or inhibitors of NS4B protein activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 9, 2010
    Publication date: November 11, 2010
    Applicant: AUSPEX PHARMACEUTICALS, INC.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Benzofuran derivatives useful for treating hyper-proliferative disorders
    Patent number: 7803956
    Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: September 28, 2010
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan H. Ladouceur, Qian Zhao, Martin F. Hentemann, Sharad K. Verma, Qingming Zhu, Rico C. Lavoie, Jianmei Fan, Barton Phillips
  • Heterocycles
    Patent number: 7750017
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly hyperproliferative diseases such as cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly hyperproliferative diseases such as cancer.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: July 6, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Chengzhi Zhang, Roger Smith, Jason Duquette, Qian Zhao, Jacques Dumas, Georgiy Bondar, Yingfu Li, Dongping Fan
  • ARYLPIPERAZINE MODULATORS OF D2 RECEPTORS, 5-HT1A RECEPTORS, AND/OR 5-HT2A RECEPTORS
    Publication number: 20100069399
    Abstract: The present invention relates to new arylpiperazine modulators of D2 receptors, 5-HT1A receptors, and/or 5-HT2A receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: February 27, 2009
    Publication date: March 18, 2010
    Applicant: AUSPEX PHARMACEUTICAL, INC.
    Inventors: Thomas G. Gant, Sepehr Sarshar, Chengzhi Zhang
  • Benzofuran derivatives useful for treating hyper-proliferative disorders
    Patent number: 7659412
    Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: February 9, 2010
    Assignee: Bayer Healthcare LLC
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan Ladouceur, Qian Zhao, Martin Hentemann, Sharad Verma, Qingming Zhu, Rico Lavoie, Jianmei Fan, Barton Phillips