Patents by Inventor Chengzhi Zhang

Chengzhi Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZOQUINOLONE INHIBITORS OF VMAT2
    Publication number: 20180208592
    Abstract: The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 28, 2017
    Publication date: July 26, 2018
    Inventors: Andreas Sommer, Chengzhi Zhang
  • Tetrahydrocarbazole Inhibitors Of SIRT1 Receptors
    Publication number: 20180127366
    Abstract: Described are deuterium-substituted tetrahydrocarbazole compounds of Formulae I, II, or III which are inhibitors of sirtuin 1 (SIRT1). Also described are pharmaceutical compositions comprising the deuterium-substituted tetrahydrocarbazole compounds, and methods of use thereof.
    Type: Application
    Filed: January 3, 2018
    Publication date: May 10, 2018
    Inventors: Chengzhi Zhang, Ralph Laufer
  • Deuterium-Substituted Pyridin- And Pyrimidin-2-yl-Methylamine Compounds
    Publication number: 20180079742
    Abstract: Described are deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds of structural Formula (I), which are agonists of 5-hydroxytryptamine receptors. Also described are pharmaceutical compositions comprising the deuterium-substituted pyridin- and pyrimidin-2-yl-methylamine compounds, and methods of use thereof.
    Type: Application
    Filed: September 20, 2017
    Publication date: March 22, 2018
    Inventor: Chengzhi ZHANG
  • Deuterium-Substituted Oxazepin Compounds
    Publication number: 20180064726
    Abstract: Described are deuterium-substituted oxazepin compounds of structural Formula I, which are inhibitors/blockers of the late sodium current. Also described are pharmaceutical compositions comprising the deuterium-substituted oxazepin compounds, and methods of use thereof.
    Type: Application
    Filed: September 7, 2017
    Publication date: March 8, 2018
    Inventors: Richard FISHER, Chengzhi ZHANG
  • DIMETHOXYPHENYL INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
    Publication number: 20180036260
    Abstract: Described are dimethoxyphenyl inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: February 17, 2016
    Publication date: February 8, 2018
    Inventor: Chengzhi ZHANG
  • Tetrahydrocarbazole inhibitors of SIRT1 receptors
    Patent number: 9884819
    Abstract: Described are deuterium-substituted tetrahydrocarbazole compounds of Formulae I, II, or III which are inhibitors of sirtuin 1 (SIRT1). Also described are pharmaceutical compositions comprising the deuterium-substituted tetrahydrocarbazole compounds, and methods of use thereof.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: February 6, 2018
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Chengzhi Zhang, Ralph Laufer
  • DEUTERIUM-SUBSTITUTED OXADIAZOLES
    Publication number: 20180016244
    Abstract: Described are deuterated modulators of S1P1 receptors, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: March 25, 2016
    Publication date: January 18, 2018
    Inventors: Chengzhi Zhang, Justin Chakma
  • Piperidine inhibitors of Janus kinase 3
    Patent number: 9856261
    Abstract: The present invention relates to new piperidine inhibitors of Janus kinase 3 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: January 2, 2018
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Formulations and pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
    Patent number: 9814708
    Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: November 14, 2017
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Andreas Sommer, Chengzhi Zhang, John Carter, John Arthur, Margaret Bradbury, Thomas Gant, Manouchehr Shahbaz
  • DIHYDROXYPHENYL NEUROTRANSMITTER COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20170319694
    Abstract: The present invention relates to new dihydoxyphenyl modulators of neurotransmitter levels, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: July 21, 2017
    Publication date: November 9, 2017
    Inventors: David S. Goldstein, Courtney Holmes, Rudolf-Giesbert Alken, Frank Schneider, Chengzhi Zhang
  • BENZOQUINOLONE INHIBITORS OF VMAT2
    Publication number: 20170246159
    Abstract: The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: May 17, 2017
    Publication date: August 31, 2017
    Inventors: Thomas G. Gant, Manouchehr Shahbaz, Chengzhi Zhang
  • METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS
    Publication number: 20170197957
    Abstract: The present invention relates to new methods of manufacturing benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), and intermediates thereof.
    Type: Application
    Filed: March 29, 2017
    Publication date: July 13, 2017
    Inventor: Chengzhi Zhang
  • Tetrahydrocarbazole Inhibitors Of SIRT1 Receptors
    Publication number: 20170190664
    Abstract: Described are deuterium-substituted tetrahydrocarbazole compounds of Formulae I, II, or III which are inhibitors of sirtuin 1 (SIRT1). Also described are pharmaceutical compositions comprising the deuterium-substituted tetrahydrocarbazole compounds, and methods of use thereof.
    Type: Application
    Filed: January 6, 2017
    Publication date: July 6, 2017
    Inventors: Chengzhi Zhang, Ralph Laufer
  • METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS
    Publication number: 20170190654
    Abstract: The present invention relates to new methods of manufacturing benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), and intermediates thereof.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 6, 2017
    Inventor: Chengzhi Zhang
  • FORMULATIONS PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
    Publication number: 20170087147
    Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
    Type: Application
    Filed: October 6, 2016
    Publication date: March 30, 2017
    Inventors: Andreas Sommer, Chengzhi Zhang, John Carter, John Arthur, Margaret Bradbury, Thomas Gant, Manouchehr Shahbaz
  • Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2
    Patent number: 9585884
    Abstract: The present invention relates to new pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: March 7, 2017
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
    Patent number: 9550780
    Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: January 24, 2017
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Andreas Sommer, Chengzhi Zhang, John Carter, John Arthur, Margaret Bradbury, Thomas Gant, Manouchehr Shahbaz
  • CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR
    Publication number: 20170002015
    Abstract: The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: September 16, 2016
    Publication date: January 5, 2017
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • QUINOLONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2
    Publication number: 20160376255
    Abstract: The present invention relates to new quinolone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof
    Type: Application
    Filed: September 9, 2016
    Publication date: December 29, 2016
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor
    Patent number: 9526711
    Abstract: The present invention relates to new biphenyl-3-carboxylic acid modulators of beta-3-adrenoceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: December 27, 2016
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventor: Chengzhi Zhang