Patents by Inventor Chengzhi Zhang

Chengzhi Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OXINDOLE INHIBITORS OF TYROSINE KINASE
    Publication number: 20160257648
    Abstract: The present invention relates to new oxindole inhibitors of tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: November 9, 2015
    Publication date: September 8, 2016
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • FORMULATIONS and PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
    Publication number: 20160235733
    Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
    Type: Application
    Filed: February 16, 2016
    Publication date: August 18, 2016
    Inventors: Andreas Sommer, Chengzhi Zhang, John Carter, John Arthur, Margaret Bradbury, Thomas Gant, Manouchehr Shahbaz
  • FORMULATIONS PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
    Publication number: 20160222008
    Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
    Type: Application
    Filed: March 16, 2016
    Publication date: August 4, 2016
    Inventors: Andreas Sommer, Chengzhi Zhang, John Carter, John Arthur, Margaret Bradbury, Thomas Gant, Manouchehr Shahbaz
  • BENZOQUINOLONE INHIBITORS OF VMAT2
    Publication number: 20160207917
    Abstract: The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof represented by structural Formula I.
    Type: Application
    Filed: September 26, 2014
    Publication date: July 21, 2016
    Inventor: Chengzhi Zhang
  • Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor
    Patent number: 9394239
    Abstract: The present invention relates to new biphenyl-3-carboxylic acid modulators of beta-3-adrenoceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: July 19, 2016
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventor: Chengzhi Zhang
  • CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR
    Publication number: 20160193212
    Abstract: The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 21, 2015
    Publication date: July 7, 2016
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
    Patent number: 9346800
    Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: May 24, 2016
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Andreas Sommer, Chengzhi Zhang, John Carter, John Arthur, Margaret Bradbury, Thomas Gant, Manouchehr Shahbaz
  • 4,6-DIAMINOPYRIMIDINE STIMULATORS OF SOLUBLE GUANYLATE CYCLASE
    Publication number: 20160122347
    Abstract: The present invention relates to new 4,6-diaminopyrimidine stimulators of soluble guanylate cyclase, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: January 11, 2016
    Publication date: May 5, 2016
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Formulations and pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
    Patent number: 9296739
    Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: March 29, 2016
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Andreas Sommer, Chengzhi Zhang, John Carter, John Arthur, Margaret Bradbury, Thomas Gant, Manouchehr Shahbaz
  • BENZOQUINOLONE INHIBITORS OF VMAT2
    Publication number: 20160068526
    Abstract: The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: January 28, 2014
    Publication date: March 10, 2016
    Inventors: Andreas Sommer, Chengzhi Zhang
  • 4,6-diaminopyrimidine stimulators of soluble guanylate cyclase
    Patent number: 9260424
    Abstract: The present invention relates to new 4,6-diaminopyrimidine stimulators of soluble guanylate cyclase, pharmaceutical compositions thereof, and methods of use thereof
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: February 16, 2016
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • Cyclopropyl modulators of P2Y12 receptor
    Patent number: 9255104
    Abstract: The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: February 9, 2016
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • BENZOQUINOLINE INHIBITORS OF VMAT 2
    Publication number: 20160030414
    Abstract: The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: August 6, 2015
    Publication date: February 4, 2016
    Inventors: Thomas G. Gant, Manouchehr Shahbaz, Chengzhi Zhang
  • Formulations and pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
    Patent number: 9233959
    Abstract: The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2 (VMAT2) activity in a subject for the treatment of chronic hyperkinetic movement disorders.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: January 12, 2016
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Andreas Sommer, Chengzhi Zhang, John Carter, John Arthur, Margaret Bradbury, Thomas Gant, Manouchehr Shahbaz
  • MACROLIDE INHIBITORS OF mTOR
    Publication number: 20150361120
    Abstract: The present invention relates to new macrolide inhibitors of mTOR, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: March 30, 2011
    Publication date: December 17, 2015
    Inventor: Chengzhi Zhang
  • PIPERIDINE INHIBITORS OF JANUS KINASE 3
    Publication number: 20150322070
    Abstract: The present invention relates to new piperidine inhibitors of Janus kinase 3 activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 12, 2015
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • OXINDOLE INHIBITORS OF TYROSINE KINASE
    Publication number: 20150284327
    Abstract: The present invention relates to new oxindole inhibitors of tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: April 4, 2014
    Publication date: October 8, 2015
    Applicant: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS
    Publication number: 20150152099
    Abstract: The present invention relates to new methods of manufacturing benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), and intermediates thereof.
    Type: Application
    Filed: November 24, 2014
    Publication date: June 4, 2015
    Inventor: Chengzhi Zhang
  • Aminothiazole modulators of beta-3-adrenoreceptor
    Patent number: 9029407
    Abstract: The present invention relates to new aminothiazole modulators of beta-3-adrenoreceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: May 12, 2015
    Assignee: Auspex Pharmaceuticals, Inc.
    Inventors: Tadimeti Rao, Chengzhi Zhang
  • SUBSTITUTED N-ARYL PYRIDONES
    Publication number: 20150126562
    Abstract: Disclosed herein are methods of administering deuterated pirfenidone and kits thereof.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 7, 2015
    Inventor: Chengzhi Zhang