Abstract: The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.

Abstract: A common interface (CI)/conditional access (CA) module is used to transmit a conditional access data/command and a transport stream in an interleaving manner between a common interface card and an integrated circuit module having a conditional access module. With the aid of the CI/CA module, a same port can be shared for transmitting the conditional access data/command and the transport stream, instead of using two different and separated ports.

Abstract: Analog front-end circuits and methods for configuring analog front-end circuits to improve accuracy of optical pulse energy digitizers are disclosed. More specifically, an analog front-end circuit in accordance with the inventive concepts disclosed herein may be configured to reduce a pulse repetition rate as early in the front-end circuit as possible. It is contemplated that reducing the repetition rate in this manner provides more process time that may be allocated for data acquisition, hold, dump, or time guard bands, all of which may help to improve the measurement accuracy of the analog front-end circuit.

Abstract: A touch apparatus and a touch method are provided. The touch apparatus includes a touch panel and a processing unit. The touch panel includes a plurality of sensing electrodes. The touch panel has a first contact surface and a second contact surface. The processing unit is configured to the touch panel. The processing unit receives a touch signal generated by the touch panel sensing a touch operation. The processing unit determines whether the operation is located on the first contact surface or on the second contact surface of the touch panel according to the touch signal and a preset condition. The preset condition is determined by a sensing signal generated by sensing the touch operation touching first contact surface or the second contact surface of the touch panel using at least one of the sensing electrodes.

Abstract: Method and apparatus for amplifying a target nucleic acid sequence of a reaction mixture in a Polymerase Chain Reaction (PCR). The method includes contacting the reaction mixture with EMR frequency absorbing particles formed from a material having a transition metal, transition metal oxide or a transition metal hydroxide, or a nitride, a phosphide or an arsenide of a Group III metal doped with the transition metal or a transition metal oxide, or silicon dioxide doped with the transition metal, transition metal oxide, or transition metal hydroxide; and irradiating the EMR absorbing particles with EMR having a frequency of about 200 kHz to 500 THz to amplify the target nucleic acid sequence, wherein the Group III metal is any one of Al, Ga, and In, and the transition metal is any one of Mn, Fe, Co and Cu.

Abstract: Disclosed herein is a refined product obtained from a rice hull, which consists essentially of a type II arabinogalactan having a number average molecular weight in the range of 56 to 103 kDa. Also disclosed are a process for producing the refined product and use of the refined product for enhancing the biological activity of innate immune cells, as well as for treating allergy and cancer.

Abstract: A medium temperature solid oxide fuel cell glass packaging material is provided. The glass packaging material may include a glass main body made of SiO2, Al2O3, Y2O3 and ZnO, and at least one glass modifier added into the glass main body. Glass transition temperature ranges from 700 to 900 degrees Celsius. The glass modifier may be rare earth elements or transitory elements. The added glass modifier may adjust the glass transition temperature and the thermal expansion coefficient, and improve the bonding characteristics of the glass packaging material, so as to allow the manufactured glass packaging material to be applicable in SOFC application temperature range from 500 to 800 degrees Celsius.

Abstract: The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleaved under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker. In some aspects of the present disclosure, the targeting moiety is an anti-HER2 antibody. The present disclosure further provides compositions and methods for treating cancers.

Abstract: The present disclosure provides anti-folate receptor alpha (FRA) antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.

Abstract: The present disclosure provides anti-CD22 antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.

Abstract: The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.

Abstract: The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.

Abstract: A solid medium of Antrodia cinnamomea comprises 20 to 50 wt % soybean; 30 to 50 wt % coixseed; and 20 to 50 wt % sorghum. A culturing method of Antrodia cinnamomea, comprises providing a solid medium comprising soybean, coixseed and sorghum; preparing a solution of Antrodia cinnamomea, inoculating the solution of Antrodia cinnamomea on the solid medium in a concentration of 1×103 to 1×106 cfu on per 100 g of solid medium, and statically culturing the solution of Antrodia cinnamomea on the solid medium till obtaining hyphae adhered on the solid medium; and culturing the solution of Antrodia cinnamomea by intermittent shaking in a frequency of every 5 to 7 days shaking 5 to 10 minutes, with a period of the culturing by intermittent shaking being more than 40 days.

Abstract: In one aspect, this application describes a method for determining a version of a software application targeted for a computing device. The method includes receiving, at an application marketplace system and from a user associated with a computing device that operates remotely from the application marketplace system, a request that corresponds to a software application distributed by the application marketplace system, the software application having multiple versions on the application marketplace system. The method also includes determining one or more device attributes that are associated with the computing device, and identifying a particular version of the software application, from among the multiple versions on the application marketplace system, that is targeted for the computing device based on the device attributes. The method also includes providing, for display to the user and in response to the request, information related to the particular version of the software application.

Abstract: In one aspect, this application describes a method for determining a version of a software application targeted for a computing device. The method includes receiving, at an application marketplace system and from a user associated with a computing device that operates remotely from the application marketplace system, a request that corresponds to a software application distributed by the application marketplace system, the software application having multiple versions on the application marketplace system. The method also includes determining one or more device attributes that are associated with the computing device, and identifying a particular version of the software application, from among the multiple versions on the application marketplace system, that is targeted for the computing device based on the device attributes. The method also includes providing, for display to the user and in response to the request, information related to the particular version of the software application.

Abstract: A touch display apparatus and an operating method of the touch display apparatus are provided. An application icon is converted into a corresponding startup gesture icon if a touch operation conforms to an icon conversion operation.

Abstract: The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.

Abstract: A pharmaceutical composition useful for hepatoprotection is provided. The composition comprises an effective amount of kinsenoside or a pharmaceutically acceptable salt or ester thereof. An aqueous extract of Anoectochilus spp. is also provided. The extract is substantially free of ethyl acetate-philic components.

Abstract: Systems and techniques are disclosed for receiving an application submitted to an application market and determining a global rank for the application based at least on a visibility rank and a risk rank. The visibility rank may be determined based on observed visibility, a probabilistic visibility, and/or an externality. The application may be placed in a review category based on the global rank. Additionally, an application priority category may be associated with the application based on the global rank.

Abstract: A medium temperature solid oxide fuel cell glass packaging material is provided. The glass packaging material may include a glass main body made of SiO2, Al2O3, Y2O3 and ZnO, and at least one glass modifier added into the glass main body. Glass transition temperature ranges from 700 to 900 degrees Celsius. The glass modifier may be rare earth elements, alkaline metal elements or transitory elements. The added glass modifier may adjust the glass transition temperature and the thermal expansion coefficient, and improve the bonding characteristics of the glass packaging material, so as to allow the manufactured glass packaging material to be applicable in SOFC application temperature range from 500 to 800 degrees Celsius.