Abstract: The invention provides methods and compositions for treating urothelial carcinoma in a patient, for example, by administering a treatment regimen that includes a PD-1 axis binding antagonist (e.g., atezolizumab) to the patient as a neoadjuvant or an adjuvant therapy based on the presence or level of ctDNA in a biological sample obtained from the patient. Also provided are compositions (e.g., a PD-1 axis binding antagonist (e.g., atezolizumab), pharmaceutical compositions thereof, kits thereof, and articles of manufacture thereof) for use in treating urothelial carcinoma in a patient.

Abstract: Provided are a noise cancellation method and apparatus, an electronic device, a noise cancellation earphone, and a storage medium. The method includes acquiring original sound source information; performing noise reduction (NR) processing on the original sound source information using active noise cancellation (ANC) to obtain first sound information and performing the NR processing on the original sound source information using environmental noise cancellation (ENC) to obtain second sound information; and mixing and adding the first sound information and the second sound information to obtain target sound information and playing the target sound information. In this method, the NR processing can be performed on the sound using the ANC and the ENC, thereby distinguishing environmental noise from human voice, improving the noise cancellation performance, and enabling a user to hear clearer sound.

Abstract: The present invention provides therapeutic and diagnostic methods and compositions for cancer (e.g., bladder cancer (e.g., UC) or kidney cancer (e.g., RCC)). The invention provides methods of identifying an individual having a cancer who is likely to respond to treatment with an anti-cancer therapy comprising a PD-L1 axis binding antagonist, methods for selecting a therapy for an individual having a cancer, methods of identifying an individual having a cancer who is less likely to respond to treatment with an anti-cancer therapy comprising a PD-L1 axis binding antagonist monotherapy, methods of monitoring the response of an individual having a cancer to treatment with an anti-cancer therapy comprising a PD-L1 axis binding antagonist, and methods of treating an individual having cancer, based on expression levels of a biomarker of the invention (e.g., one or more genes set forth in any one of Tables 1-7, e.g., IL8).

Abstract: During operation, a computer system may apply a pretrained predictive model to information for at least a subset of a plurality of individuals, and may determine levels of uncertainty in results of the pretrained predictive model for at least the subset of the plurality of individuals. Then, the computer system may dynamically adapt a at least one threshold range based at least in part on the determined levels of uncertainty and a predefined target performance of the pretrained predictive model for the plurality of individuals. Next, the computer system may perform different remedial actions for a first group of individuals in the plurality of individuals having the results where the levels of uncertainty are within the at least one threshold range and a second group of individuals in the plurality of individuals having the results where the levels of uncertainty are outside of the at least one threshold range.

Abstract: When picking a die from an adhesive tape, a collet of a pick arm is positioned at a distance over the die, the die being mounted on a first surface of the adhesive tape. A flow of air is then generated onto a second surface of the adhesive surface opposite to the first surface for blowing the adhesive tape to displace the die towards a die-holding surface of the collet. Thereafter, the die is retained on the die-holding surface of the collet while the adhesive tape separates from the die.

Abstract: A method for forming a retardation optical film is provided. The method includes: adding a diamine monomer (A) and a dianhydride monomer (A) in a solvent (A) to react to form a polyimide slurry; adding the polyimide slurry into a solvent (B) to precipitate out a plurality of polyimide fibers; washing the plurality of polyimide fibers with a solvent (C); mixing the plurality of polyimide fibers with a solvent (D) to obtain a soluble polyimide solution; reacting a diamine monomer (B) and a dianhydride monomer (B) to form a polyamic acid solution; coating a mixed solution including the soluble polyimide solution and the polyamic acid solution on a substrate; and heating to form a retardation optical film made of polyimide on the substrate.

Abstract: Disclosed herein are recombinant antibodies or the fragment thereof for detecting severe acute respiratory syndrome coronavirus (SARS-CoV). According to some embodiments, the SARS-CoV is SARS-CoV-1. According to some alternative embodiments, the SARS-CoV is SARS-CoV-2. Also disclosed herein are a kit comprising the recombinant antibodies, and a method for diagnosing the infection of SARS-CoV by using the recombinant antibody or the kit.

Abstract: A heat dissipation structure, includes: a lead frame, including a high temperature pad and a low temperature pad, the high temperature pad and the low temperature pad being two portions in the lead frame which are separated from each other, wherein a high heat generation component is disposed on the high temperature pad; and a high thermal conduction element, including two sides which are respectively directly connected with the high temperature pad and the low temperature pad, to dissipate the heat energy from the high heat generation component to the low temperature pad.

Abstract: A slave device coupled to a master device via a bus and including a serial interface, a code generator circuit, and a control circuit is provided. The serial interface is configured to be coupled to the bus. The code generator circuit is configured to generate a unique code. The control circuit is coupled between the serial interface and the code generator circuit. In a set mode, the control circuit triggers the code generator circuit to generate the unique code. In an operation mode, the control circuit determines whether to perform commands provided by the master device according to the unique code.

Abstract: Methods for determining suitability of Czochralski growth conditions to produce silicon substrates for epitaxy. The methods involve evaluating substrates sliced from ingots grown under different growth conditions (e.g., impurity profiles) by imaging the wafer by infrared depolarization. An infrared depolarization parameter is generated for each epitaxial wafer. The parameters may be compared to determine which growth conditions are well-suited to produce substrates for epitaxial and/or post-epi heat treatments.

Abstract: A method of fabricating a thin film with a varying thickness includes the steps of providing a shadow mask with an opening, providing a carrier plate, arranging a substrate on the carrier plate, and coating the substrate through the opening whilst rotating the carrier plate relative to the shadow mask. A plurality of zones of the substrates is swept and exposed from arcuate portions of the opening per each turn by a plurality of predetermined exposure times, respectively. The varying thickness of the thin film corresponds to variation of the predetermined exposure times.

Abstract: When picking a die from an adhesive tape, a collet of a pick arm is positioned at a distance over the die, the die being mounted on a first surface of the adhesive tape. A flow of air is then generated onto a second surface of the adhesive surface opposite to the first surface for blowing the adhesive tape to displace the die towards a die-holding surface of the collet. Thereafter, the die is retained on the die-holding surface of the collet while the adhesive tape separates from the die.

Abstract: Document collaboration methods and systems that allow multiple users to create and edit a document are described. Such methods and systems can support devices that receive and process edits to one or more documents while the devices are off-line relative to a document collaboration service. These methods and systems can use a network based storage system (e.g., a “cloud storage platform”) to store a document (e.g., “cloud storage document”) that represents a recent collaboration state of the document based upon edits received from users who are (or have been) using the document collaboration service while one or more other users are off-line.

Abstract: A system for producing a silicon ingot, the system includes a crystal puller, a pyrometer, an infrared (IR) camera, and a controller. The crystal puller includes a hot zone having one or more components therein, and in which a silicon ingot may be pulled. The pyrometer is positioned to view a region of interest within the hot zone. The IR camera is positioned to view one or more additional regions of interest within the hot zone. The controller is connected to the crystal puller, the pyrometer, and the IR camera. The controller is programmed to control the crystal puller to produce a silicon ingot, receive temperature data of the region of interest within the hot zone from the pyrometer while producing the silicon ingot, and receive IR images of the one or more additional regions of interest from the IR camera while producing the silicon ingot.

Abstract: A pneumatic tool includes a casing unit, an air motor, a rotary valve, and a turning unit. The rotary valve is mounted to the air motor and is rotatable about a valve axis. The turning unit includes a ring member that surrounds and is rotatably mounted to the casing unit, and that is connected to the rotary valve, such that rotation of the ring member relative to the casing unit drives the rotary valve to rotate about the valve axis relative to the air motor among a first-end position, a second-end position and at least one in-between position for adjusting airflow that travels from an air inlet passage of the casing unit, through an opening and an intermediate passage of the rotary valve, to an air chamber of the air motor.

Abstract: A pneumatic tool includes a casing unit, an air motor, a rotary valve, and a turning unit. The rotary valve is rotatably mounted to the air motor. The turning unit is movably mounted to the casing unit, and is connected to the rotary valve such that movement of the turning unit relative to the casing unit drives rotation of the rotary valve relative to the air motor to one of a first-end position, a second-end position and at least one in-between position, in which an opening of the rotary valve is in spatial communication with a respective one of a first passage, a second passage and at least one sub-passage for adjusting airflow that travels from an air inlet passage of the casing unit, through the rotary valve, and into the air motor.

Abstract: A method of fabricating a thin film with a varying thickness includes the steps of providing a shadow mask with an opening, providing a carrier plate, arranging a substrate on the carrier plate, and coating the substrate through the opening whilst rotating the carrier plate relative to the shadow mask. A plurality of zones of the substrates is swept and exposed from arcuate portions of the opening per each turn by a plurality of predetermined exposure times, respectively. The varying thickness of the thin film corresponds to variation of the predetermined exposure times.

Abstract: This application discloses methods and compositions for use in treating cancer, including breast cancer (such as metastatic triple negative breast cancer, mTNBC), urothelial carcinoma, renal cell carcinoma, and liver cancer (hepatocellular carcinoma, HCC) with the combination of a PD-1 axis binding antagonist (e.g., a PD-L1 binding antibody such as atezolizumab) and an IL6 antagonist (e.g. an anti-IL6 receptor antibody such as tocilizumab), optionally further comprising a VEGF antagonist (e.g. an anti-VEGF antibody such as bevacizumab). Optionally, the patient has C-reactive protein (CRP) and/or IL-6 level(s) above the upper limit of normal. Optionally, the cancer is PD-L1 positive.

Abstract: A slave device coupled to a master device via a bus and including a serial interface, a code generator circuit, and a control circuit is provided. The serial interface is configured to be coupled to the bus. The code generator circuit is configured to generate a unique code. The control circuit is coupled between the serial interface and the code generator circuit. In a set mode, the control circuit triggers the code generator circuit to generate the unique code. In an operation mode, the control circuit determines whether to perform commands provided by the master device according to the unique code.

Abstract: Document collaboration methods and systems that allow multiple users to create and edit a document are described. Such methods and systems can support devices that receive and process edits to one or more documents while the devices are off-line relative to a document collaboration service. These methods and systems can use a network based storage system (e.g., a “cloud storage platform”) to store a document (e.g., “cloud storage document”) that represents a recent collaboration state of the document based upon edits received from users who are (or have been) using the document collaboration service while one or more other users are off-line.