Abstract: This invention provides for synthesis of citrulline from a transition metal complex of ornithine using cyanate to derivatize the terminal amino group of ornithine. The invention also provides improved methods for purification of citrulline produced by reaction of cyanate with ornithine via the steps of reprecipitation of copper complex of citrulline, removal of the complexing metal by sulfide precipitation, activated carbon adsorption and antisolvent crystallization.

Abstract: A front airbag (10) includes an inflatable chamber (18) having a baffle surface (16) provided to cushion an occupant (14) to be restrained, wherein a tether (28) extending inside the inflatable chamber (18) is provided which, when the front airbag (10) is mounted on the vehicle and is inflated, extends obliquely with respect to a vehicle longitudinal direction (L) and which is fastened with a first longitudinal end (34) to a single baffle surface-side fastening point (30) at the baffle surface (16).

Abstract: A process for producing a device for use in filtration, chemical processes or electrochemical processes is described, the device comprising a porous layer and a supporting layer comprising channels running in the plane of the supporting layer and being open towards the porous layer. The process comprises providing a stack comprising a) the porous layer, or a green part of the porous layer which green part contains a sinterable material powder and a binder, or a partially debound green part of the porous layer, and b) a green part of the supporting layer. The process further comprises the green part of the supporting layer being applied on the porous layer or the green part of the porous layer or the partially debound green part of the porous layer by additive manufacturing from a sinterable material powder and a binder in a layer-by-layer wise manner; sintering the green parts; and thermally bonding the stack.

Abstract: A front airbag (10) for the protection of a vehicle occupant (12) in a vehicle which is specifically a passenger airbag for the protection of a passenger, in the installed and inflated state includes a contact wall (20) facing the vehicle occupant (12) and an opposite rear wall (22) as well as a first sidewall (24) facing the vehicle center as seen by the vehicle occupant (12) and an opposite second sidewall (26). The airbag (10) further includes a limiting device which, in the inflated state of the airbag (10), prevents the first sidewall (24) from further deploying so that the airbag (10) takes a first volume. The limiting device can be influenced when the head (14) of the vehicle occupant (12) contacts the airbag (10) such that it allows the first sidewall (24) to further deploy so that the airbag (10) takes a second volume larger as compared to the first volume.

Abstract: A binder component for a feedstock compound for use in a shaping and sintering process comprises b-i) 3 to 70% by volume of at least one first thermoplastic and/or wax-type material, and b-ii) 30 to 97% by volume of at least one second thermoplastic and/or wax-type material, based on the total volume of the binder component b). The first thermoplastic and/or wax-type material and the second thermoplastic and/or wax-type material differ in at least one property which property is selected from (1) solubility in a solvent, (2) degradability induced by heat and/or a reactant, and (3) volatility. The first thermoplastic and/or wax-type material is less soluble, less degradable or less volatile than the second thermoplastic and/or wax-type material.

Abstract: This invention provides for synthesis of citrulline from a transition metal complex of ornithine using cyanate to derivatize the terminal amino group of ornithine. The invention also provides improved methods for purification of citrulline produced by reaction of cyanate with ornithine via the steps of reprecipitation of copper complex of citrulline, removal of the complexing metal by sulfide precipitation, activated carbon adsorption and antisolvent crystallization.

Abstract: A particulate feedstock compound for use in a powder bed additive manufacturing process comprises a) sinterable non-organic particles having a maximum particle size of 200 ?m dispersed throughout the compound particle, and b) a binder component, the binder component comprising, relative to the volume of the binder component b-i) 3 to 70% by volume of a thermoplastic polyamide having a DSC melt peak temperature TP below 160° C., and b-ii) 30 to 97% by volume of a wax or wax-type material having a drop point in the range of 20 to 160° C. Upon irradiation with an energy beam, the feedstock compound particles are converted from solid to fluid at comparably low temperature and form a dense green part without affecting adjacent feedstock compounds.

Abstract: Provided are novel Substituted Thiophene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R7 are as defined herein, as well as compositions comprising at least one Substituted Thiophene Derivative, and methods of using the Substituted Thiophene Derivatives for treating or preventing cancer in a patient.

Abstract: The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.

Abstract: Fast quantitative NMR data acquisition for NMR scans performed on a sample is provided. Scan batches on the sample are performed, where each batch comprises a long delay scan, followed by a set of short delay scans. Each scan is associated with a corresponding scan time point in relation to the long delay scan time point of the respective scan batch. For each corresponding scan time point, aggregated NMR spectrum portions are determined showing a decay over time, which is fitted with an exponential decay function. An averaged integral loss is computed for each scan time point. For each NMR spectrum of the scan batches, an integral associated with a respective region of interest is multiplied with a corresponding correction factor. The integrals associated with the corrected NMR spectra are summed to obtain a representation of the NMR signal intensity in the region of interest for the sample.

Abstract: Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.

Abstract: A binder component for a feedstock compound for use in a shaping and sintering process comprises b-i) 3 to 70% by volume of at least one first thermoplastic and/or wax-type material, and b-li) 30 to 97% by volume of at least one second thermoplastic and/or wax-type material, based on the total volume of the binder component. The first thermoplastic and/or wax-type material and the second thermoplastic and/or wax-type material differ in at least one property which property is selected from (1) solubility in a solvent, (2) degradability induced by heat and/or a reactant, and (3) volatility. The first thermoplastic and/or wax-type material is less soluble, less degradable or less volatile than the second thermoplastic and/or wax-type material. Tcross is below 120° C., wherein Tcross is the temperature at the intersection between the storage modulus G? curve and the loss modulus G? curve in a dynamic viscoelasticity measurement of the binder component.

Abstract: A binder component for a feedstock compound for use in a shaping and sintering process comprises b-i) 3 to 70% by volume of at least one first thermoplastic and/or wax-type material, and b-ii) 30 to 97% by volume of at least one second thermoplastic and/or wax-type material, based on the total volume of the binder component. The first thermoplastic and/or wax-type material and the second thermoplastic and/or wax-type material differ in at least one property which property is selected from (1) solubility in a solvent, (2) degradability induced by heat and/or a reactant, and (3) volatility. The first thermoplastic and/or wax-type material is less soluble, less degradable or less volatile than the second thermoplastic and/or wax-type material. The binder component exhibits a melt viscosity, as determined at a temperature of 130° C.; and at a shear rate of 1 s?1, of below 6 Pa·s.

Abstract: A binder component b) for a particulate feedstock compound for use in a shaping and sintering process contains b-i) 3 to 70% by volume of a polyolefin, a polyolefin wax or an oxidized polyolefin wax, and b-lii) 30 to 97% by volume of a non-polymeric wax or non-polymeric wax-type substance, or a water-soluble or water-dispersible thermoplastic polymer, based on the total volume of the binder component b). The feedstock compound containing the binder component and non-organic sinterable particles is used in an additive manufacturing process, an injection molding process, a pressing process or a casting process.

Abstract: A method for manufacturing a coated object, in which a partially cured intermediate object formed from a dual-curable material is formed by an additive manufacturing method, in which at least some regions of the partially cured intermediate object are coated with a coating material and in which the partially cured intermediate object is completely cured in a curing step to form the object. In one aspect, a polyurethane resin is used as the dual-curable material.

Abstract: A front airbag (10) for the protection of a vehicle occupant (12) in a vehicle which is specifically a passenger airbag for the protection of a passenger, in the installed and inflated state includes a contact wall (20) facing the vehicle occupant (12) and an opposite rear wall (22) as well as a first sidewall (24) facing the vehicle center as seen by the vehicle occupant (12) and an opposite second sidewall (26). The airbag (10) further includes a limiting device which, in the inflated state of the airbag (10), prevents the first sidewall (24) from further deploying so that the airbag (10) takes a first volume. The limiting device can be influenced when the head (14) of the vehicle occupant (12) contacts the airbag (10) such that it allows the first sidewall (24) to further deploy so that the airbag (10) takes a second volume larger as compared to the first volume.

Abstract: An observation system for observing a region of interest. The observation system has multiple mobile sensor carrier platforms and a resource allocation unit. The mobile sensor carrier platforms may be configured as satellites having a sensor signal emitter and/or a sensor signal receiver, for example. The resource allocation unit is configured to assign tasks to the sensor carrier platforms on the basis of various criteria in order to improve the efficiency for carrying out the tasks and the completion rate.

Abstract: The invention refers to an implant device, in particular to a pubic symphysis implant device, and to an implant system comprising two such implant devices. The implant device of the invention comprises a bent body comprising a curved middle portion and two lateral arms extending away from the middle portion and being mutually joined by the middle portion, and at least one guiding element defining at least one guiding path along which a tensioning element can be guided. The invention further refers to method of fixating together a first bone or bone part and a second bone or bone part, for example for re-joining a disjoined pubic symphysis, using such an implant system, in particular by placing each of the two implant devices on corresponding bones or bone parts and by pulling the two implant devices towards each other by tensioning a tensioning element guided along the at least one guiding path of each of the two implant devices.

Abstract: A pyrotechnic tightening device 1 of a safety belt unit having a force limiting unit, comprising—a gas generator, and—a piston 19, which is guided in a pipe and which closes a pressure chamber inside the pipe, wherein—a pressure can be applied to the pressure chamber by the gas generator, and—the piston can be driven by the pressure present in the pressure chamber to perform a tightening movement which can be transmitted by means of a force transmitting unit to the safety belt, wherein—the piston is formed in two parts consisting of a main body and a contact part arranged on the side of the main body facing the force transmitting unit, wherein—the contact part has a greater strength than the main body, wherein—the main body surrounds the contact part form fittingly at the end face facing the force transmitting device.

Abstract: A process for the additive manufacture of a metallic and/or vitreous and/or ceramic component, a mixture of substrate particles and an at least two-phase binder is firstly provided. The mixture is preferably provided as composite particles, so that the substrate particles adhere to one another by the at least two-phase binder. The mixture is selectively melted layerwise by electromagnetic radiation so that a shaped part is additively produced. The shaped part is taken out from the mixture which has not been melted and the at least two-phase binder is subsequently removed, preferably successively. The process produces a microporous shaped part which after sintering leads to a component having a desired density and a desired mechanical and/or thermal stability.