Abstract: A seatbelt tensioner for a seat belt retractor, having a pipe (1) with a tensioner drive wheel, a gas generator (10), a piston (3), and at least one mass body (4). The mass body (4) is drivable by gas from the gas generator (10) acting on the piston (3) between the gas generator (10) and a mass body (4). The mass body drives the tensioner drive wheel. The pipe (1) has a receiving section (5) with a first inner diameter (2), in which the piston (3) in its initial state is arranged with an initial-state outer diameter (8). The pipe (1) has a guide section (6) which adjoins the receiving section (5) and which has a second inner diameter (7). The second inner diameter (7) is smaller than the first inner diameter (2) and smaller than the initial-state outer diameter (8) of the piston (3).

Abstract: The invention relates to a belt tightener (1) with a mass body drive for a seat belt of a motor vehicle with a force-limiting device with —a belt shaft (3) mounted rotatably in at least one opening (15) of a housing (14) that can be fastened fixedly to the vehicle, it being possible to wind up the seat belt on said shaft, —a tightener drive wheel (24) connected non-rotatably to the belt shaft (3) and having recesses (14) distributed at regular intervals over the circumference, —a chain forming the mass body drive made of loose mass bodies (19), which are guided in a tightener tube (10) and can be driven by pressure application of the tightener tube (10), wherein —the belt shaft (3) can be driven in the winding direction of the seat belt by engagement of the driven mass bodies (19) in the recesses (14) of the tightener drive wheel (24), wherein —the mounting of the belt shaft (3) in the opening (15) of the housing (14) is designed to be flexible in the radial direction.

Abstract: The present invention relates to compounds of formula (A), wherein Z is NR10 or O. These compounds represent novel acridinium and xanthylium salts having an unprecedented substituted heterocyclic core. They are useful as fluorescent dyes or precursors thereof in different applications including various imaging and sensing techniques, and, in particular, as photosensitizers and hereby preferably as photocatalysts. The present invention further relates to processes for preparing the inventive compounds via 1,5-organodimetallic reagents from double directed ortho-metalation reactions or combined halogen-metal exchange/directed ortho-metalation reactions.

Abstract: A process for the additive manufacture of a metallic and/or vitreous and/or ceramic component, a mixture of substrate particles and an at least two-phase binder is firstly provided. The mixture is preferably provided as composite particles, so that the substrate particles adhere to one another by the at least two-phase binder. The mixture is selectively melted layerwise by means of electromagnetic radiation so that a shaped part is additively produced. The shaped part is taken out from the mixture which has not been melted and the at least two-phase binder is subsequently removed, preferably successively. The process produces a microporous shaped part which after sintering leads to a component having a desired density and a desired mechanical and/or thermal stability.

Abstract: The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.

Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

Abstract: A system and method for tunneling through a network separation device such as a firewall or a Network Address Translator including a first server receiving an access request from a client device to communicate with a host device, where the host device is behind the network separation device. The first server sending a message to a second server in response to receiving the access request, the message including host data for the host device. The second server is configured to send a notification to the host device, and the notification includes instructions for the host device to initialize a pass-through channel with the first server. The first server receiving a pass-through initialization request from the host device and establishing the pass-through channel for communication between the client device and the host device in response to receiving the pass-through initialization request.

Abstract: An apparatus for setting up a ladder or a step on a staircase comprises: a platform on which the ladder or the step can be set up; and a frame to support the platform on the staircase. The frame comprises at least two legs each pivotable about a common pivot axis or about respective pivot axes, wherein the common pivot axis or the respective pivot axes lie in a plane of the platform or parallel to the plane of the platform.

Abstract: A device for processing wafer-shaped articles comprises a closed process chamber that provides a gas-tight enclosure. A rotary chuck is located within the closed process chamber. A heater is positioned relative to the chuck so as to heat a wafer shaped article held on the chuck from one side only and without contacting the wafer shaped article. The heater emits radiation having a maximum intensity in a wavelength range from 390 nm to 550 nm. At least one first liquid dispenser is positioned relative to the chuck so as to dispense a process liquid onto a side of a wafer shaped article that is opposite the side of the wafer-shaped article facing the heater.

Abstract: The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

Abstract: Systems and methods for improved NMR signal detection are described. The system receives NMR signal data produced by a sample over time in response to an excitation pulse and selects a predefined system function for application to the NMR signal data for systematic variation of signal properties The system function has a different influence on NMR signal components than on noise components of the sampled signal and has a variation parameter to control the systematic variation. A plurality of variation parameter values is provided with differing values to influence broad NMR signals as well as weak NMR signals. The system generates for each variation parameter value a corresponding intermediate data set by applying the system function with the respective variation parameter value to the NMR signal data. Further, from each intermediate data set, a respective base value centered spectrum is generated in the frequency-domain.

Abstract: An electrochemical cell includes a composite electrode body with at least one positive and at least one negative electrode; an electrolyte that impregnates the composite electrode body; and a housing with a liquid-impervious interior, wherein the composite electrode body impregnated with the electrolyte is disposed in the interior, and the housing consists of PEK or a PEK based material.

Abstract: The present invention provides a compound of Formula (I) (represented as tautomers Ia and Ib) or the pharmaceutically acceptable salts thereof, which are KDM5 inhibitors.

Abstract: The present invention provides a compound of Formula (I) (represented as tautomers Ia and Ib): (I) or the pharmaceutically acceptable salts thereof, which are KDM5 inhibitors.

Abstract: Systems and methods for improved NMR signal detection are described. The system receives NMR signal data produced by a sample over time in response to an excitation pulse and selects a predefined system function for application to the NMR signal data for systematic variation of signal properties The system function has a different influence on NMR signal components than on noise components of the sampled signal and has a variation parameter to control the systematic variation. A plurality of variation parameter values is provided with differing values to influence broad NMR signals as well as weak NMR signals. The system generates for each variation parameter value a corresponding intermediate data set by applying the system function with the respective variation parameter value to the NMR signal data. Further, from each intermediate data set, a respective base value centered spectrum is generated in the frequency-domain.

Abstract: The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is —C(R1)? or —N?; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.

Abstract: The present invention relates to Substituted Heterocyclic Compounds of Formula (I): R1—R2—R3—R4?? (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, and R4 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Heterocyclic Compound, and methods of using the Substituted Heterocyclic Compounds for inhibiting PRDM9 activity in a subject or for treating or preventing a disease mediated by PRDM9 activity.

Abstract: An information encoder for encoding an information signal includes: a converter for converting the linear prediction coefficients of the predictive polynomial A(z) to frequency values f1 . . . fn of a spectral frequency representation of the predictive polynomial A(z), wherein the converter is configured to determine the frequency values f1 . . . fn by analyzing a pair of polynomials P(z) and Q(z) being defined as P(z)=A(z)+z?m?lA(z?1) and Q(z)=A(z)?z?m?lA(z?1), wherein m is an order of the predictive polynomial A(z) and l is greater or equal to zero, wherein the converter is configured to obtain the frequency values by establishing a strictly real spectrum derived from P(z) and a strictly imaginary spectrum from Q(z) and by identifying zeros of the strictly real spectrum derived from P(z) and the strictly imaginary spectrum derived from Q(z).

Abstract: The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.