Abstract: The disclosure relates to medical devices and methods of manufacturing medical devices. An orthopedic screw includes an inner core member having a head having a first outer diameter, a tip having a second outer diameter, and a body extending between the head and the tip and having a third outer diameter that is less than the first outer diameter and the second outer diameter. An outer body member is disposed circumferentially around the body of the inner core member and defines an outer body member external thread. The tip of the inner core member can define an inner core member external thread that forms an interrupted thread with the outer body member external thread.

Abstract: A device cleans a core engine of a jet engine. The device has: a nozzle installation which is configured for introducing a cleaning medium into the core engine; a connector configured to connect the device in a rotationally fixed manner to a shaft of a fan of the jet engine; and a line connection configured to supply the cleaning medium, which is connected to the nozzle installation by a rotary coupling. The nozzle installation comprises nozzles, comprising at least one flat jet nozzle, and at least one full cone nozzle or hollow cone nozzle.

Abstract: A drive device for a motor vehicle includes a drive machine and a transmission device having a triple planetary great set and having a first and second clutch, wherein the triple planetary gear set has a plurality of triple planet gears, wherein each triple planet gear includes a first gear, a second gear, and a third gear. The three gears of each triple planet gear are connected to each other for conjoint rotation and are jointly rotatably accommodated on a planet carrier, and the drive machine is connected to the triple planetary gear set by the first clutch and a first sun gear or by the second clutch and a second sun gear.

Abstract: A drive device includes a drive machine, such as an electric motor, gear reduction planetary gear sets, and a differential. One of the gear reduction planetary gear sets utilizes multi-step planetary gears. The differential is a spur gear differential. To reduce axial length, one of the gearwheels of each multi-step planetary gears axially overlaps with planetary gears of the spur gear differential.

Abstract: A device cleans a core engine of a jet engine. The device has: a nozzle installation configured to introduce a cleaning medium into the core engine; a connector configured to connect the device in a rotationally fixed manner to a shaft of a fan of the jet engine; and a line connection configured to supply the cleaning medium, the line connection being connected to the nozzle installation by a rotary coupling. The nozzle installation has first contact faces configured to bear axially on fan blades of the fan, the first contact faces being configured for defined positioning of the nozzle installation relative to the jet engine.

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Abstract: The present invention relates to an amatoxin-linker construct comprising an amatoxin according to formula (I) wherein: R1 and R2 are each —OH, R3 is NH2, or a linker which carries a reactive group Y for linking said amatoxin to a target-binding moiety, R4 is H or a linker which carries a reactive group Y for linking said amatoxin to a target-binding moiety, R5 is absent or ?O, wherein R3 and R4 cannot be the same, for use in the manufacture of a binding moiety-toxin conjugate for the treatment of a solid tumor, and a respective binding moiety-toxin conjugate for the treatment of a solid tumor.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: Amatoxins, as well as antibody-drug conjugates (ADCs) comprising an amatoxin are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, as well as prevention of graft-versus-host-disease (GVHD), are provided.

Abstract: The invention relates to a PSMA-targeting conjugate comprising (a) an amatoxin; (b) a small molecule PSMA-targeting moiety; and (c) optionally a linker linking said amatoxin and said small molecule PSMA-targeting moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Abstract: A flexible surgical screw driver comprises a rotatable handle member, a shaft member and a flexible member. The handle member is configured with a first coupling means and the shaft member with a second coupling means. These first and second coupling means are configured to cooperate such that the handle member and the shaft member are angularly displaceable relative to each other and such that said handle member and said shaft member are non-rotatably coupled to each other for driving a screw with rotation transmitted from the handle member. The flexible member is configured to connect the handle member and the shaft member to each other and hold said handle member and said shaft member together such that the longitudinal axes thereof are substantially aligned and such that angular displacement of the handle member and the shaft member relative to each other such that the longitudinal axes thereof are misaligned, can be performed against the action of said flexible member.

Abstract: The invention relates to a powder paint comprising at least one base powder paint and at least one effect powder paint having effect pigments, said effect pigments being dispersed in a melt made from transparent effect powder paint. The invention also relates to a method for producing said type of powder paint and to an effect powder coating containing said type of powder paint.

Abstract: The invention relates to ?-amaninamide (1; x=0, 1 or 2), ?-amaninamidic acid (2; x=0, 1 or 2), and ?-amaninamidic hydroxamic acid (3; x=0, 1 or 2), novel derivatives of ?-amanitin (4), and methods and novel building blocks for the synthesis thereof.

Abstract: The disclosure relates to medical devices and methods of manufacturing medical devices. An intramedullary rod includes a head member, a shaft member partially disposed within a distal recess of the head member, and an outer body member disposed circumferentially around the shaft member and a portion of the head member. Medical device systems and methods of manufacturing medical devices are also described.

Abstract: The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4?, 5? or 7? of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.

Abstract: An assembly for assisting with positioning of an intervertebral implant, including an implant holder having an elongate body extending along a longitudinal axis between first and second ends, the first end being adapted to be attached to the stabilising wedge of an intervertebral implant, the first end of the implant holder having a deflection device including an opening having a central axis substantially perpendicular to the longitudinal axis of the implant holder but not converging with the longitudinal axis, the opening allowing the braid of an implant to pass therethrough in such a way that, when in use, the braid may have a first portion extending substantially perpendicularly to the longitudinal axis from the implant to the opening, and a second portion extending from the opening to the free end in a plane substantially parallel to the longitudinal axis of the implant holder to allow the tensioning of the braid.

Abstract: A drive device for a motor vehicle includes a drive machine and a transmission device having a triple planetary great set and having a first and second clutch, wherein the triple planetary gear set has a plurality of triple planet gears, wherein each triple planet gear includes a first gear, a second gear, and a third gear. The three gears of each triple planet gear are connected to each other for conjoint rotation and are jointly rotatably accommodated on a planet carrier, and the drive machine is connected to the triple planetary gear set by the first clutch and a first sun gear or by the second clutch and a second sun gear.

Abstract: A drive device includes a drive machine, such as an electric motor, gear reduction planetary gear sets, and a differential. One of the gear reduction planetary gear sets utilizes multi-step planetary gears. The differential is a spur gear differential. To reduce axial length, one of the gearwheels of each multi-step planetary gears axially overlaps with planetary gears of the spur gear differential.