Abstract: The disclosure relates to medical devices and methods of manufacturing medical devices. An intramedullary rod includes a head member, a shaft member partially disposed within a distal recess of the head member, and an outer body member disposed circumferentially around the shaft member and a portion of the head member. Medical device systems and methods of manufacturing medical devices are also described.

Abstract: A screw includes a head part, a threaded part and a flexible connector between the head part and the threaded part for transmitting a torsional force between the head part and the threaded part, and to allow two bending movements between the head part and the threaded part in opposite directions in the longitudinal axis of the screw. The head part and the threaded part in each case have a longitudinal axis, which can be arranged offset in parallel to one another. The screw has an ?-modulus of between 20,000 and 100,000 N/mm2 against a rotation in the case of an arrangement of the head part and the threaded part on a longitudinal axis.

Abstract: The invention relates to a method for producing an osteosynthetic implant, comprising the steps of producing a load-bearing metal component and coating the load-bearing component with a biocompatible material.

Abstract: A guide wire control device for advancing a guide wire into a body or a portion of the body, comprises a handle member (1), a lever (2) and a spring means (3). The spring means (3) holds the lever (2) relative to the handle member (1) such that the longitudinal axis of a through-hole (9) in the lever (2) is misaligned with the longitudinal axis of an elongate passage (4) in the handle member (1) for locking the guide wire control device to a guide wire (5) extending through said elongate passage and said through-hole. Pivotal movement of the lever (2) brings the longitudinal axis of the through-hole (9) into alignment or substantial alignment with the longitudinal axis of the elongate passage (4) for release of the guide wire (5). Pivotal movement of the lever (2) also brings the longitudinal axis of the through-hole (9) into renewed misalignment with the longitudinal axis of the elongate passage (4) for clamping of the guide wire (5).

Abstract: The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6?-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a BCMA-binding moiety comprising (i) the variable domains of humanized antibody J22.9-ISY, and (ii) a heavy chain constant region comprising a D265C mutation; and (c) a protease-cleavable linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of multiple myeloma.

Abstract: The present invention relates to an intramedullary nail for proximal femoral fractures. The intramedullary nail comprises an elongate body (1) with a longitudinal bore (2). The elongate body (1) includes a proximal portion (5) with an oblique transverse bore (7) for a proximal locking member and a distal portion (6) with at least one transverse bore (8) for a distal locking member. An inlet end of the oblique transverse bore (7) is configured as a recess (9) with a recessed surface (11). The recessed surface (11) is composed of recessed lateral surface portions (15) and a recessed proximal as well as a recessed distal surface portion (16 and 17 respectively). Each of the recessed lateral surface portions (15) is configured with at least one protuberance (18) for preventing or reducing the risk for misalignment of e.g. a reamer and, if misalignment occurs, this will not affect critical parts of the intramedullary nail.

Abstract: The disclosure relates to medical devices and methods of manufacturing medical devices. An intramedullary rod includes a head member, a shaft member partially disposed within a distal recess of the head member, and an outer body member disposed circumferentially around the shaft member and a portion of the head member. Medical device systems and methods of manufacturing medical devices are also described.

Abstract: The disclosure relates to medical devices and methods of manufacturing medical devices. An orthopedic screw includes an inner core member having a head having a first outer diameter, a tip having a second outer diameter, and a body extending between the head and the tip and having a third outer diameter that is less than the first outer diameter and the second outer diameter. An outer body member is disposed circumferentially around the body of the inner core member and defines an outer body member external thread. The tip of the inner core member can define an inner core member external thread that forms an interrupted thread with the outer body member external thread.

Abstract: A flexible surgical screw driver comprises a rotatable handle member, a shaft member and a flexible member. The handle member is configured with a first coupling means and the shaft member with a second coupling means. These first and second coupling means are configured to cooperate such that the handle member and the shaft member are angularly displaceable relative to each other and such that said handle member and said shaft member are non-rotatably coupled to each other for driving a screw with rotation transmitted from the handle member. The flexible member is configured to connect the handle member and the shaft member to each other and hold said handle member and said shaft member together such that the longitudinal axes thereof are substantially aligned and such that angular displacement of the handle member and the shaft member relative to each other such that the longitudinal axes thereof are misaligned, can be performed against the action of said flexible member.

Abstract: A guide wire control device for advancing a guide wire into a body or a portion of the body, comprises a handle member (1), a lever (2) and a spring means (3). The spring means (3) holds the lever (2) relative to the handle member (1) such that the longitudinal axis of a through-hole (9) in the lever (2) is misaligned with the longitudinal axis of an elongate passage (4) in the handle member (1) for locking the guide wire control device to a guide wire (5) extending through said elongate passage and said through-hole. Pivotal movement of the lever (2) brings the longitudinal axis of the through-hole (9) into alignment or substantial alignment with the longitudinal axis of the elongate passage (4) for release of the guide wire (5). Pivotal movement of the lever (2) also brings the longitudinal axis of the through-hole (9) into renewed misalignment with the longitudinal axis of the elongate passage (4) for clamping of the guide wire (5).

Abstract: The invention relates to ?-amaninamide (1; x=0, 1 or 2), ?-amaninamidic acid (2; x=0, 1 or 2), and ?-amaninamidic hydroxamic acid (3; x=0, 1 or 2), novel derivatives of ?-amanitin (4), and methods and novel building blocks for the synthesis thereof.

Abstract: The invention relates to a powder paint comprising at least one base powder paint and at least one effect powder paint having effect pigments, said effect pigments being dispersed in a melt made from transparent effect powder paint. The invention also relates to a method for producing said type of powder paint and to an effect powder coating containing said type of powder paint.

Abstract: The present disclosure relates to tumour therapy. In one aspect, the present disclosure relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

Abstract: The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer and other disorders and diseases. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

Abstract: A screw includes a head part, a threaded part and a flexible connector between the head part and the threaded part for transmitting a torsional force between the head part and the threaded part, and to allow two bending movements between the head part and the threaded part in the opposite direction in the longitudinal axis of the screw, wherein the head part and the threaded part in each case have a longitudinal axis, which can be arranged offset in parallel to one another, and wherein the screw has an ?-module of between 20,000 and 100,000 N/mm2 against a rotation in the case of an arrangement of the head part and the threaded part on a longitudinal axis.

Abstract: The present invention relates to an intramedullary nail for proximal femoral fractures. The intramedullary nail comprises an elongate body (1) with a longitudinal bore (2). The elongate body (1) includes a proximal portion (5) with an oblique transverse bore (7) for a proximal locking member and a distal portion (6) with at least one transverse bore (8) for a distal locking member. An inlet end of the oblique transverse bore (7) is configured as a recess (9) with a recessed surface (11). The recessed surface (11) is composed of recessed lateral surface portions (15) and a recessed proximal as well as a recessed distal surface portion (16 and 17 respectively). Each of the recessed lateral surface portions (15) is configured with at least one protuberance (18) for preventing or reducing the risk for misalignment of e.g. a reamer and, if misalignment occurs, this will not affect critical parts of the intramedullary nail.

Abstract: The invention relates to novel methods for synthesizing a synthon for ?,?-dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.

Abstract: The invention relates to novel methods for synthesizing a synthon for ?,?-dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.

Abstract: The invention relates to a method for producing an osteosynthetic implant, comprising the steps of producing a load-bearing metal component and coating the load-bearing component with a biocompatible material.

Abstract: The present invention discloses a system for securing at least one fastener to an implant. At least one adhesive capsule is inserted in a recess preferably located along a longitudinal axis of the implant. The at least one adhesive capsule may be inserted in the recess and held in place therein by a holder. A plurality of adhesive capsules and holders may be inserted in one or more recesses located substantially along the longitudinal axis of the implant. The at least one adhesive capsule preferably has a casing housing an adhesive material configured to be pierced by the at least one fastener to secure the at least one fastener to an aperture of the implant. The casing of the adhesive capsule may form an annular passageway to receive a guide wire for aiding the insertion of the capsule in an implant having a longitudinal bore along at least a portion thereof.