Abstract: The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer and other disorders and diseases. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

Abstract: The invention relates to novel methods for synthesizing a synthon for ?,?-dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.

Abstract: The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

Abstract: A two-piece clamping element comprises two separate, i.e., non-integral, opposing first and second clamping jaws forming a laterally open cavity to receive a pin or rod-shaped element. Each clamping jaw has a bore aligned with one another to receive a screw, wherein a pivot bearing is arranged opposite said cavity allowing the two opposing clamping jaws to come in contact to one another. The pivot bearing comprises at least one set of complementary part-cylindrical bearing surface portions. An anti-rotation pin extends between the two jaw members.

Abstract: A steering arrangement for a motor vehicle includes a rotatable steering handle, in particular a steering wheel, and a steering spindle connected torsion-tight therewith. At least one generator device is provided for generating at least one haptic signal, and at least one rocker bar is fixed on a structural part of the steering arrangement in a fixing region. On the rocker bar, a pinging hammer is held such that it is deflectable with respect to the fixing region, and the rocker bar for the deflection of the pinging hammer is connected with the generator device. The pinging hammer can be brought into contact with a structural part of the steering arrangement.

Abstract: A two-piece clamping element comprises two separate, i.e., non-integral, opposing first and second clamping jaws forming a laterally open cavity to receive a pin or rod-shaped element. Each clamping jaw has a bore aligned with one another to receive a screw, wherein a pivot bearing is arranged opposite said cavity allowing the two opposing clamping jaws to come in contact to one another. The pivot bearing comprises at least one set of complementary part-cylindrical bearing surface portions. An anti-rotation pin extends between the two jaw members.

Abstract: The invention relates to a pelvic or scapular bone plate implant having a planar or curved outer frame portion. The frame has a surface which can be aligned with a surface of a bone to which the bone plate is to be implanted. The plate has a flap portion, the outer frame portion at least partially surrounds the flap portion such that the bone contacting surface the flap portion is located within the outer boundary of the frame portion. The flap portion is connected with the outer frame portion via a material interconnection which allows the flap to be bent with respect to the frame. A method for implanting such a bone plate implant is also taught.

Abstract: The present invention discloses a system for securing at least one fastener to an implant. At least one adhesive capsule is inserted in a recess preferably located along a longitudinal axis of the implant. The at least one adhesive capsule may be inserted in the recess and held in place therein by a holder. A plurality of adhesive capsules and holders may be inserted in one or more recesses located substantially along the longitudinal axis of the implant. The at least one adhesive capsule preferably has a casing housing an adhesive material configured to be pierced by the at least one fastener to secure the at least one fastener to an aperture of the implant. The casing of the adhesive capsule may form an annular passageway to receive a guide wire for aiding the insertion of the capsule in an implant having a longitudinal bore along at least a portion thereof.

Abstract: A two-piece clamping element comprises two separate, i.e., non-integral, opposing first and second clamping jaws forming a laterally open cavity to receive a pin or rod-shaped element. Each clamping jaw has a bore aligned with one another to receive a screw, wherein a pivot bearing is arranged opposite said cavity allowing the two opposing clamping jaws to come in contact to one another. The pivot bearing comprises at least one set of complementary part-cylindrical bearing surface portions. An anti-rotation pin extends between the two jaw members.

Abstract: The present invention discloses a system for securing at least one elongate fastener to an implant. At least one adhesive capsule is inserted in a recess preferably located along a longitudinal axis of the implant. The at least one adhesive capsule may be inserted in the recess and held in place therein by a holder. A plurality of adhesive capsules and holders may be inserted in one or more recesses located substantially along the longitudinal axis of the implant. The at least one adhesive capsule preferably has a casing housing an adhesive material configured to be pierced by the at least one fastener to secure the at least one fastener to an aperture of the implant. The casing of the adhesive capsule may form an annular passageway to receive a guide wire for aiding the insertion of the capsule in an implant having a longitudinal bore along at least a portion thereof.

Abstract: The present invention discloses a system for releasing one or more therapeutic agents contained within a capsule onto or into an implant. At least one capsule is inserted in a recess preferably located along a longitudinal axis of the implant. The at least one adhesive capsule may be inserted in the recess and held in place therein by a holder. A plurality of adhesive capsules and holders may be inserted in one or more recesses located substantially along the longitudinal axis of the implant. The at least one capsule preferably has a casing housing one or more therapeutic agents, wherein the capsule is configured to be pierced by the at least one fastener to release the one or more therapeutic agents. The casing of the capsule may form an annular passageway to receive a guide wire for aiding the insertion of the capsule in an implant having a longitudinal bore along at least a portion thereof.

Abstract: The invention relates to a pelvic or scapular bone plate implant having a planar or curved outer frame portion. The frame has a surface which can be aligned with a surface of a bone to which the bone plate is to be implanted. The plate has a flap portion, the outer frame portion at least partially surrounds the flap portion such that the bone contacting surface the flap portion is located within the outer boundary of the frame portion. The flap portion is connected with the outer frame portion via a material interconnection which allows the flap to be bent with respect to the frame. A method for implanting such a bone plate implant is also taught.

Abstract: An implantable orthopedic device having a load-bearing element, such as a bone plate, with at least one opening for a fixation element and one insert which can be inserted in an inclined opening in a receptacle in the bore. This insert has an external form that is at least partially complementary to the internal form of the receptacle and a central through-bore for receiving the body of the fixation element such as a bone screw. The insert also provides a locking system for holding the insert in the receptacle, in which the insert exhibits at least one locking mechanism with which conformal locking with the load-bearing element may be achieved.

Abstract: The present invention discloses a system for releasing one or more therapeutic agents contained within a capsule onto or into an implant. At least one capsule is inserted in a recess preferably located along a longitudinal axis of the implant. The at least one adhesive capsule may be inserted in the recess and held in place therein by a holder. A plurality of adhesive capsules and holders may be inserted in one or more recesses located substantially along the longitudinal axis of the implant. The at least one capsule preferably has a casing housing one or more therapeutic agents, wherein the capsule is configured to be pierced by the at least one fastener to release the one or more therapeutic agents. The casing of the capsule may form an annular passageway to receive a guide wire for aiding the insertion of the capsule in an implant having a longitudinal bore along at least a portion thereof.

Abstract: The present invention discloses a system for securing at least one elongate fastener to an implant. At least one adhesive capsule is inserted in a recess preferably located along a longitudinal axis of the implant. The at least one adhesive capsule may be inserted in the recess and held in place therein by a holder. A plurality of adhesive capsules and holders may be inserted in one or more recesses located substantially along the longitudinal axis of the implant. The at least one adhesive capsule preferably has a casing housing an adhesive material configured to be pierced by the at least one fastener to secure the at least one fastener to an aperture of the implant. The casing of the adhesive capsule may form an annular passageway to receive a guide wire for aiding the insertion of the capsule in an implant having a longitudinal bore along at least a portion thereof.

Abstract: A device for stimulating the osteogenesis of a traumatized bone is mounted on a bone stabilizing implant. The device comprises a first component part comprising a first electrode, an isolating element, which is mounted at the first component part and a second component part comprising a second electrode. The second component part is mounted at the isolating element such that the first electrode and the second electrode are electrically isolated from each other. The power generation unit is electrically coupled both to the first electrode and to the second electrode. The first component part is designed to be attached to the implant in such a manner that the second component part intrudes in a region defined by a trauma within the bone.

Abstract: A steering arrangement for a motor vehicle includes a rotatable steering handle, in particular a steering wheel, and a steering spindle connected torsion-tight therewith. At least one generator device is provided for generating at least one haptic signal, and at least one rocker bar is fixed on a structural part of the steering arrangement in a fixing region. On the rocker bar, a pinging hammer is held such that it is deflectable with respect to the fixing region, and the rocker bar for the deflection of the pinging hammer is connected with the generator device. The pinging hammer can be brought into contact with a structural part of the steering arrangement.

Abstract: The invention relates to a device for fixing an at least height-adjustable steering column. The device includes a clamping device provided with a clamping element having an open position in which the height adjustment is released. When the clamping element passes from the opening position thereof to the closed position thereof, toothings engage with each other. A blocking element has a blocking position in which it blocks the lifting of the counter-fixing part from the fixing part, maintaining the engagement of the toothings, and a release position in which the counter-fixing part can be lifted from the fixing part.

Abstract: In a method for the production of a corrugated tube from a flat metal sheet, two half shells are formed each extending in a longitudinal direction, and the half shells are provided with corrugations oriented transversely to their longitudinal direction. The two half shells are either disposed in a single sheet metal part longitudinally next to one another or are separate parts. In the case of their formation with two half shells disposed in a common sheet metal part next to one another, the preformed sheet metal part in the region between the two half shells is folded or curved about an axis parallel to the longitudinal directions of the half shells, wherein free longitudinal edges of the half shells are brought into mutual contact and are connected with one another. In the case of the formation of the half shells in the form of separate parts, the two half shells are placed against one another with their longitudinal edges and the longitudinal edges are connected with one another.

Abstract: The subject of the present invention are specific phospholipidesters of clofarabine and the use of such lipidesters in the treatment of tumors.