Abstract: Provided are novel Substituted Thiophene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R7 are as defined herein, as well as compositions comprising at least one Substituted Thiophene Derivative, and methods of using the Substituted Thiophene Derivatives for treating or preventing cancer in a patient.

Abstract: System and methods for cleaning and inspecting a pipe are disclosed. The system may include a flexible shaft having a distal end and a proximal end opposite the distal end, a sheath comprising a flexible tube body that extends over at least part of the flexible shaft and includes a distal end and a proximal end, wherein the flexible tube body includes a bore within which the flexible shaft extends, at least one electrical conductor contained within the flexible tube body of the sheath, the at least one electrical conductor extending at least partially along a length of the flexible tube body, and a camera operatively connected to the at least one electrical conductor.

Abstract: In implementation of techniques for upsampling a digital material model based on radiances, a computing device implements an upsampling system to receive an input digital material model having a first resolution. The upsampling system generates a bilinearly upsampled texel based on the input digital material model having the first resolution. The upsampling system then generates a texel having a second resolution that is higher than the first resolution based on the bilinearly upsampled texel using a machine learning model trained on training data to generate texels. Based on the texel having the second resolution, the upsampling system generates an output digital material model having a resolution that is higher than the first resolution.

Abstract: The invention provides a method for recycling material, such as rigid panels or soft board, based on natural fibers comprising grinding the board at room temperature and atmospheric pressure, by exclusively mechanical action to obtain bulk fibers. In some cases, the rigid board to be recycled may undergo a mechanical pre-treatment step of destructuration/deplanarisation prior to grinding.

Abstract: Methods and systems are provided for conformal cage-based deformation with polynomial curves. In embodiments described herein, a cage model in a first configuration is displayed along with an image. The cage model in the first configuration defines a boundary of at least a portion of points of the image. Curve control points are generated along the boundary of the cage model. The cage model is deformed from the first configuration to a second configuration by changing the location of curve control points thereby changing curvature of a corresponding portion of the boundary of the cage model. Based on the first and second configuration of the cage model, an updated image is generated by performing a conformal transformation of the points of the image within the boundary of the cage model in the first configuration. The updated image is then displayed.

Abstract: An optical vital signs sensor is provided which comprises a PPG sensor (100), a pre-processing unit (130) which adapts the sampling rate or the number of pulses per sample, a processing unit (140) which executes at least one processing algorithm based on an output signal of the pre-processing unit and a sensor control unit (150). The sensor control unit is configured to control the PPG sensor by adapting the sampling rate and/or the number of pulses per sample.

Abstract: The present invention relates to a device (10) for determining an arterial compliance of a subject (12). The device (10) comprises an inflatable cuff (14), a pressure sensor (18) which is configured to sense a pressure signal (52) that is indicative of a pressure within the cuff (14), a second sensor (20) which is at least partly integrated in the cuff (14) and configured to sense a second signal (56) that is responsive to expansions and contractions of the cuff (14) caused by a pulsating blood flow in an artery (50) of the subject (12), and a processing unit (22). The processing unit is configured to determine based on said part of the pressure signal (52) a pulse pressure of the subject (12), to determine based on said part of the second signal (56) an arterial volume change of the artery (50) of the subject (12) during at least one cardiac cycle, and to determine the arterial compliance of the subject (12) based on pulse pressure and the arterial volume change.

Abstract: A data processing device (100, 200) is disclosed for extracting a desired vital signal containing a physiological information component from sensor data that includes time-dependent first sensor data (PPG1) comprising the physiological information component and at least one motion artifact component, and that includes time-dependent second sensor data that is indicative of a position, a velocity or an acceleration of the sensed region as a function of time. A decomposition unit (104, 204) decomposes the second sensor data into at least two components of decomposed sensor data and, based on the decomposed second sensor data, provides at least two different sets of motion reference data in at least two different motion reference data channels. An artifact removal unit (106, 206) determines the vital signal formed from a linear combination of the first sensor data and the motion reference data of at least one two of the motion reference data channels.

Abstract: Model predictive control is used to obtain the best performance value for an objective in a dynamic environment. One or more best performance values for a model predictive application are obtained by utilizing asymmetric dynamic behavior that pushes the process to the edges of the operative window. When a setpoint becomes infeasible, a controller slows down when moving away from a specified setpoint. When the infeasibility clears and the controller starts moving back towards the setpoint, the controller follows a tuned speed. When the controller moves in a direction against economic profit, the controller slows down and when moving in the direction of economic profit, the controller follows the tuned dynamic speed. The controller computes the best performance value for each controlled variable and is equal to the setpoint for the controlled variables with a setpoint or the highest profit value between limits for controlled values affected by economic functions.

Abstract: A method, system, computer-readable media, and apparatuses for providing a shared vehicle experience between a user located in a remote location and one or more occupants of a vehicle. A device associated with the user receives an exterior video stream corresponding to an exterior environment of the vehicle, along with occupant information comprising location of the one or more occupants in the vehicle. Based on the occupant information, a first augmented video stream is generated. The first augmented video stream comprises one or more dynamic avatars representing each of the occupants of the vehicle, and shows the exterior environment of the vehicle from a perspective of a virtual passenger of the vehicle. The first augmented video stream is displayed to the user to provide the user with an experience of being in the vehicle.

Abstract: A method, system, computer-readable media, and apparatuses for providing a shared vehicle experience. The method includes capturing an exterior video stream that depicts an exterior environment of a vehicle, and receiving remote user information indicating a bodily movement of a remote user. The method further includes generating and displaying an augmented video stream comprising a dynamic avatar representing the remote user as a virtual passenger, the dynamic avatar being updated based on the remote user information while the augmented video stream is being displayed in the vehicle. At least a portion of the exterior video stream and occupant information are sent to a computer device that causes, based on the at least a portion of the exterior video stream and the occupant information, a display device of the remote user to output an additional augmented video stream that provides the remote user with an experience of being in the vehicle.

Abstract: The present invention relates to a device for supplying electrical power to a wired system for a drone (1). The device according to the invention includes at least one power converter (4) on the ground and one power converter (2) at the level of the drone (1), regulation at the level of the converter on the ground ensures that the output voltage of the power converter (4) on the ground increases when the output current of the power converter (4) on the ground increases. The method according to the invention is intended for all wired drones, the wire (3) of which is used to supply electrical power to the drone (1).

Abstract: A planetary transmission, comprising a housing, a drive part, an output part having an output shaft that is rotatable about an output axis of rotation, and at least one gear stage between the drive part and the output part. The drive part, the at least one gear stage, and the output part are mounted in the housing, the housing has an output flange on the output side, wherein the output flange has a first lateral surface with circularly symmetrical in radial planes about an axis of symmetry, wherein the first lateral surface is arranged eccentrically with respect to the output axis of rotation.

Abstract: It is advantageous to handle certain conditions when equipment (or equipment components) is taken out-of-service or shutdown for service or maintenance. Equipment service flags may be used to indicate that an individual variable will no longer be propagated as the associated equipment has been taken out of line for service. When multiple variables feed another system or component downstream, those variables may be placed in an equipment service set and that set may be associated with an indicator that indicates that the group of variables in the equipment service set is unavailable. A visual indicator as to which variables have been made unavailable for propagation may be displayed to a user. Once the equipment or system is brought back online or is taken out of equipment service mode, the appropriate flags and equipment service set are reset and associated variables are once again propagated downstream.

Abstract: The present disclosure is based upon the identification of a number of Streptococcus agalactiae genes which are required for virulence in fish species. Specifically, the disclosure relates to genomic content present in fish-associated S. agalactiae strains that is absent from strains which are non-virulent to fish. Further disclosed is the use of a number of S. agalactiae proteins and antigens in methods, immunogenic compositions and vaccines for raising immune responses and treating or preventing diseases, conditions and/or infections with a Streptococcal aetiology.

Abstract: It is advantageous to switch an active element with a background element. By using a switching mechanism, a background element can be made active while the application remains active. That is, the application does not need to be taken offline to switch the active element with a previously loaded background element. Single input/single output (SISO) relationships are defined for background elements and an active element which provides one or many functions and an active element which provides one or many functions between one input variable and one output variable. The switching mechanism acts on a given SISO relationship to determine the background element to use to replace the active element.

Abstract: A device for food and/or beverage temperature regulation includes a cooler for providing a cooling mode in which the food and/or beverage is cooled, a heater for providing a heating mode in which the food and/or beverage is heated, and a pre-heating mode in which the food and/or beverage is pre-heated. A controller is configured to control the cooler and heater. The controller is further configured to activate the cooling or heating mode in response to signals indicative of a change in the behavior of a recipient of the food and/or beverage, and to activate the pre-heating mode in response to predicted behavior. The signals may represent sound and/or movement and may originate from sensors, such as microphones and/or radar sensors.

Abstract: The temporary relaxation of constraints permits the efficient and cost-effective operation of certain process models. Ramp imbalances are controlled using soft-landing constraints. Such soft-landing constraints permit a smooth return to a ramp limit which permits continued operation of a system, such as a petrochemical system that includes several inflows and outflows, as opposed to a forced shut-down of the system. A ramp imbalance may be controlled by determining imbalance ramp rates and imbalance set-point ramp rates and using those constraints to resolve the dynamic control problem of a process model.

Abstract: The present invention relates to a portable device for determining a heart rate of a person, said portable device comprising: a heart rate measurement unit for measuring the heart rate of the person over time to generate a heart rate signal, a motion measurement unit for measuring the motion of a body part of the person over time to generate a motion signal, and a processing unit which is adapted to measure a signal quality of the heart rate signal, to calculate the heart rate based on the heart rate signal if said signal quality is above a predefined threshold, and to estimate the heart rate based on the motion signal if said signal quality is below said threshold.

Abstract: The present invention relates to a device for supplying electrical power to a wired system for a drone (1). The device according to the invention includes at least one power converter (4) on the ground and one power converter (2) at the level of the drone (1), regulation at the level of the converter on the ground ensures that the output voltage of the power converter (4) on the ground increases when the output current of the power converter (4) on the ground increases. The method according to the invention is intended for all wired drones, the wire (3) of which is used to supply electrical power to the drone (1).