Abstract: An adapter for coupling with medical vials has a housing with a center longitudinal axis. The adapter includes first latching portions on an inner circumference for latching to a first closing cover of a first vial, and second latching portions on the inner circumference for latching to a second closing cover of a second vial. The second closing cover has a larger diameter than the first closing cover. The housing has web portions and spring arm portions extending between the web portions and on which the first latching portions are arranged. The housing is elastically deformable from a first state, in which the spring arm portions latch with the first latching cover, into a second state, in which the spring arm portions allow a latching connection between the second latching portions and the second closing cover. The adapter device can be used in infusion therapy.

Abstract: A method for optimizing operations of high-performance computing (HPC) systems includes collecting data associated with a plurality of workload performance profiling counters associated with a workload during runtime of the workload in an HPC system. Based on the collected data, the method includes using a machine-learning technique to classify the workload by determining a workload-specific fingerprint for the workload. The method includes identifying an optimization metric to optimize during running of the workload in the HPC system. The method includes determining an optimal setting for a plurality of tunable hardware execution parameters as measured against the optimization metric by varying at least a portion of the plurality of tunable hardware execution parameters.

Abstract: A coupling device for an adapter for a vial for a medical liquid. The coupling device is configured to connect the adapter to the vial. The coupling device has an elastic structure for adjusting the adapter to accommodate different sizes of the vial.

Abstract: An application device for applying a flowable medium onto a substrate, having a discharge valve having a closure member which, in its open position, releases a metering opening of the discharge valve, such that the flowable medium can flow through the metering opening in the direction of the substrate, wherein the closure member is movable by an electromagnet of the discharge valve from a closing position, in which it closes the metering opening, to an open position, and having a main control unit, which is connected to the discharge valve, and which delivers electrical output voltage signals which moves and maintains the closure member to the open position. A modification unit is arranged between the main control unit and the discharge valve, which is configured such it receives output voltage signals from the main control unit, modifies these signals and relays the latter in a modified form to the electromagnet.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: A sports ball, for example a soccer ball, comprising a hollow shell and a pit suspended within the hollow shell by a plurality of cords. In some embodiments, the plurality of cords may comprise a first end coupled to the hollow shell at a first location, a second end coupled to the hollow shell at a second location, and a center portion coupled to the pit. In some embodiments, the pit may be suspended within the hollow shell by a plurality of cords, with each of the plurality of cords comprising a frayed end secured to the hollow shell at one of a plurality of spaced apart locations.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: A valve arrangement for applying flowable medium to a substrate, in particular hotmelt adhesive, which valve arrangement has a distribution element and a heating device, the heating device being arranged outside the distribution element and being fastened, preferably detachably, as a unit to the distribution element.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: A valve for flowable media having a valve housing and an elongate closure member arranged therein and which can be axially moved in a medium channel of the valve by a controllable actuator and which in a closed position abuts a valve seat and closes a discharge opening connected to the medium channel, and which is connected to a sealing element to seal the medium channel, namely, a part-piece of an elongate bellows, which moves in an axial direction during movements of the closure member and which is a hollow member made of metal, wherein another part-piece of the bellows is fixedly supported in the valve. The relative axial position between the bellows and the valve seat is adapted to a production-related deviation of the longitudinal dimension of the bellows used from a desired longitudinal dimension so that this deviation is compensated for.

Abstract: A valve arrangement for applying flowable medium to a substrate, having a main valve body with a medium channel for flowable media which is able to be closed by a movable closure member and to which a nozzle part having a nozzle opening of the valve arrangement is connected, wherein the valve arrangement has a pivotable lever movable out of a fastening position and into a releasing position, wherein the pivotable lever, during the movement from the fastening position into the releasing position, exerts a detaching force on the nozzle part in order to support the detachment of the nozzle part from the main valve body. In a first phase of its movement out of the fastening position and into the releasing position, the lever is movable in a straight line and exerts the detaching force on a push-off surface of the nozzle part, and entrains the nozzle part.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: An insert assembly unit for a muffler of an exhaust system of an internal combustion engine includes two walls (12, 14) arranged at spaced locations from one another. Each of the two walls has a circumferential edge area (20, 22) configured for fixing at a circumferential wall of a muffler. An exhaust gas flow unit (26) is arranged between the two walls. The exhaust gas flow unit includes a flow duct area (34) with an exhaust gas outer flow opening (38) to be positioned directed towards an opening in a circumferential wall of a muffler, a first mounting duct area (40) with a first mounting opening (44) for fixing the exhaust gas flow unit at a first wall of the walls, and a second mounting duct area (42) with a second mounting opening (46) for fixing the exhaust gas flow unit at a second wall of the walls.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.