Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

Abstract: A tire pressure monitoring unit is for mounting on a vehicle wheel, having a sensor for measuring the tire pressure, a transmitter and a receiver for wireless data transmission, a memory for storing tire data, and a controller connected to the sensor, the transmitter, the receiver and the memory. The controller writes this tire data into the memory on receipt of tire data received via the receiver and assigns a value to a variable, the value marking this tire data as valid. It is provided that a necessary condition for the variable to be assigned a value which marks the tire data as invalid is that the controller detects a pressure increase that exceeds a predetermined threshold value. In addition, a corresponding method for managing tire data in a data memory of a tire pressure monitoring unit is described.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

Abstract: An exhaust gas heater for an exhaust gas system of a combustion engine includes a disk-like carrier defining a heater longitudinal axis and having a first axial side. The carrier has an outer peripheral region disposed radially outwardly of the longitudinal axis and a radially inwardly disposed central region. A heating conductor has a heating region arranged on the first axial side of the carrier. At least one holding member holds the heating conductor on the carrier. The holding member includes at least one holding portion engaging around the heating conductor at the heating region thereof. The carrier has at least one fastening opening formed therein. The holding member includes at least one fastening portion engaging into the at least one fastening opening so as to be fixed to the carrier.

Abstract: An insert assembly unit for a muffler of an exhaust system of an internal combustion engine includes two walls (12, 14) arranged at spaced locations from one another. Each of the two walls has a circumferential edge area (20, 22) configured for fixing at a circumferential wall of a muffler. An exhaust gas flow unit (26) is arranged between the two walls. The exhaust gas flow unit includes a flow duct area (34) with an exhaust gas outer flow opening (38) to be positioned directed towards an opening in a circumferential wall of a muffler, a first mounting duct area (40) with a first mounting opening (44) for fixing the exhaust gas flow unit at a first wall of the walls, and a second mounting duct area (42) with a second mounting opening (46) for fixing the exhaust gas flow unit at a second wall of the walls.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

Abstract: A valve for free-flowing media, such as a glue valve, with a valve housing, and with a closure member, such as a valve tappet, which is movable in the valve housing by means of an electromagnet and which bears with a closure piece on a valve seat in the closed position of the valve and which sits at least partially in a continuous interior of a one-piece coil carrier on which the windings of a coil of the electromagnet are wound, and having two terminal receivers for a dosing unit and a valve lift adjustment unit with an elongate abutment part which is arranged at least in part in the interior of the coil carrier and which limits a movement of the closure member in the direction of the valve lift adjustment unit, with the valve lift adjustment unit being is secured on the coil carrier.

Abstract: A process for ultrasonically consolidating particulates in an ink onto a substrate at ambient temperatures in less than 5 seconds to form a completely dense, well adhered functional coatings is disclosed. The coating can be used for electronic components. The process is applicable to various substrates such as metals, plastics and ceramics.

Abstract: A glue valve arrangement having a controllable, in particular electromagnetically operated metering member for the delivery of glue, having a main body with glue duct leading to the metering member, having a tubular glue line, with which glue originating from a separate glue source can be fed to the glue duct, having a rotary feedthrough, detachably fastened to the main body, for the articulated connection of the tubular glue line to the main body, and having a filter for the filtering of the glue. The invention is characterized in that the filter is assigned to the rotary feedthrough.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

Abstract: A process to produce a workpiece surface or a groove inner surface on a rod-shaped, especially cylindrical workpiece. From the workpiece, a rotary tool is supposed to be produced. The material removal is done using laser beam pulses, which are directed through a deflection device onto points of incidence within a pulse area with a specified outside contour on the workpiece. Multiple machine axis drives position the workpiece and the deflection device relative to one another so that the pulse area is oriented essentially at right angles to the emission direction of the laser beam pulses and at right angles to the section of the tool surface that has already been produced and that borders the pulse area. While the material is being removed, the at least one machine axis drive moves the pulse area relative to the workpiece along a specified path of motion while maintaining the orientation.

Abstract: A modular valve for free-flowing media, with a main module with a valve housing and an electromagnet, a dosing module with a closure member which is movable by means of the electromagnet and which closes a dispensing opening of the dosing module, and a valve lift adjustment module for adjusting the valve lift, which valve lift adjustment module comprises an elongate abutment part which is arranged at least in part in a valve interior of the main module and is modifiable in its axial position in the valve interior, which abutment part limits the movement of the closure member in the direction of the valve lift adjustment module, the dosing module and the valve lift adjustment module being connected releasably to the main module in such a way that the dosing module and the valve lift adjustment module can each be replaced by another module of the same module type.

Abstract: A valve for free-flowing media, such as a glue valve, with a valve housing, and with a closure member, such as a valve tappet, which is movable in the valve housing by means of an electromagnet and which bears with a closure piece on a valve seat in the closed position of the valve and which sits at least partially in a continuous interior of a one-piece coil carrier on which the windings of a coil of the electromagnet are wound, and having two terminal receivers for a dosing unit and a valve lift adjustment unit with an elongate abutment part which is arranged at least in part in the interior of the coil carrier and which limits a movement of the closure member in the direction of the valve lift adjustment unit, with the valve lift adjustment unit being is secured on the coil carrier.

Abstract: A valve for free-flowing media, in particular a glue valve, with a valve housing, and with a closure member, in particular a valve tappet, which is movable in the valve housing by means of an electromagnet and which bears with a closure piece on a valve seat in the closed position of the valve and which sits at least partially in an in particular continuous interior of a preferably one-piece coil carrier on which the windings of a coil of the electromagnet are wound, and with a valve lift adjustment unit with an elongate abutment part which is arranged at least in part in the interior of the coil carrier and which limits a movement of the closure member in the direction of the valve lift adjustment unit, with the valve lift adjustment unit being is secured on the coil carrier.

Abstract: A power electronic arrangement having a power semiconductor module and an external load-connecting element is provided with the external load-connecting element has a first connection device, and the power semiconductor module has a housing, a base plate and an internal load-connecting element with a second connection device, wherein the base plate has a first cut out through which the first connection device extends into the interior of the power semiconductor module and is connected there in a frictionally locking and electrically conductive fashion to a second connection device of the internal load-connecting element.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

Abstract: RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.

Abstract: The invention relates to a power semiconductor device with a substrate and an electrically conductive DC voltage bus bar system and a capacitor connected to the bus bar system, wherein the power semiconductor device has, for securing the capacitor, a capacitor securing apparatus comprising a receptacle device for receiving the capacitor, in which at least part of the capacitor is arranged. Electrically conductive bus bar system terminal elements are electrically connected thereto and run in the direction of the substrate. An elastic first deformation element is materially bonded to the capacitor securing apparatus and is formed from an elastomer is arranged on the side of the capacitor securing apparatus facing the DC voltage bus bar system.

Abstract: A power electronic arrangement having a power semiconductor module and an external load-connecting element is provided with the external load-connecting element has a first connection device, and the power semiconductor module has a housing, a base plate and an internal load-connecting element with a second connection device, wherein the base plate has a first cut out through which the first connection device extends into the interior of the power semiconductor module and is connected there in a frictionally locking and electrically conductive fashion to a second connection device of the internal load-connecting element.

Abstract: A system (1) for producing foods, in particular a chocolate system, comprising at least one treatment station and at least one industrial robot (2, 3), which comprises at least one effector (4) having at least one receiving device for at least one product carrier (14) and comprises at least one manipulator (13) for transferring the at least one product carrier (14). The industrial robot (2, 3) additionally comprises at least one control device, preferably at least one associated processing device, and the control device is or can be set in such a way that the product carrier (14), preferably at and/or opposite a treatment station and/or between two treatment stations, can be shaken, spun, turned, rotated, slid, raised, lowered, blown at, suctioned out, cleaned, stacked and/or unstacked, cleared out by knocking, emptied, filled, temperature-controlled, and/or, in particular under sensor control, moved along a predetermined path.