Abstract: The present invention relates to pharmaceutical formulations for heterodimeric Fc-fused proteins which are advantageous for achieving higher titers of the proteins during production, higher stability during storage, and improved efficacy when used as a therapeutic. Also provided are dosage regimens for such heterodimeric Fc-fused proteins and pharmaceutical formulations for use in treating cancer, such as locally advanced or metastatic solid tumor.

Abstract: A system and a method are disclosed for enabling seamlessly tracking a location of a water vessel by supplementing satellite data with mobile data location based on proximity of a water vessel to shore. The system receives a Global Positioning System (GPS) location of the water vessel, the GPS location of the water vessel based on using the satellite data of the water vessel. The system determines that the GPS location is within a threshold distance of a boundary. Responsive to determining that the GPS location is within the threshold distance of the boundary, the system initiates monitoring for a mobile signal emanating from a trajectory path of the water vessel. The system detects, during the monitoring, the mobile signal, the tracking the location of the water vessel based on mobile data of the mobile signal. The system provides the tracked location to a monitoring device.

Abstract: Described herein are multispecific binding proteins that bind NKG2D receptor, CD 16, and EGFR, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer.

Abstract: A personal protective equipment (PPE) apparatus for patient donning during medical treatment is disclosed. The apparatus includes a portable frame and cover configured to surround the patient and mitigate the spread of airborne pathogens generated by the patient to the healthcare provider and surrounding environment.

Abstract: Described herein are pharmaceutical formulations comprising multi-specific binding proteins that bind to NKG2D, CD16, and epidermal growth factor receptor (EGFR); and therapeutic uses of the multi-specific binding proteins and pharmaceutical formulations thereof for treating a disease, for example, cancer, in a patient in need thereof.

Abstract: A power transfer system comprises a patient transport apparatus and a power transfer device. The power transfer system provides convenience and ease of connection between a power source and the patient transport apparatus to provide power to one or more electrically powered devices on the patient transport apparatus or to provide energy for an energy storage device on the patient transport apparatus.

Abstract: A patient support apparatus for removably retaining differently-sized portable electronic devices. The patient support apparatus comprises a base, a litter with a patient support deck for supporting the patient, and a side rail. The side rail is coupled to the litter and arranged for movement relative to the base. The side rail includes a caddy comprising a back, a first brace, and a second brace spaced from the first brace. The first brace extends laterally from the back and defines a first bottom support region. The second brace extends laterally from the back and defines a second bottom support region converging toward the first bottom support region to arrange the first and second bottom support regions to provide differing points of contact for retaining differently-sized portable electronic devices.

Abstract: Steam cracking of ethane, a non-catalytic thermochemical process, remains the dominant means of ethylene production. The severe reaction conditions and energy expenditure involved in this process incentivize the search for alternative reaction pathways and reactor designs which maximize ethylene yield while minimizing cost and energy input. According to the present invention, ethylene yields as high as 68% were obtained with a quartz open tube reactor without the use of a catalyst or a cofed stream of oxidizing agents. The open tube reactor design promotes simplicity, low cost, and negligible coke formation. Reactor designs can be optimized to improve the conversion of ethane to ethylene via non-oxidative dehydrogenation, an approach which shows promise for decentralized production of ethylene from natural gas deposits.

Abstract: High surface area, high entropy oxides comprising multiple metal cations in a single-phase fluorite lattice material enables intrinsic catalytic activity without platinum group metals, tunable oxygen storage capacity, and thermal stability. These properties can be obtained through a facile sol-gel synthesis to provide a low-temperature route for production of phase-pure multi-cationic oxides. The resulting materials achieved significantly higher surface area and catalytic performance, taking advantage of all the properties endowed by the various cations in the composition.

Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting 5T4 on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.

Abstract: The present disclosure relates to synthetic bones used in bone-related human and animal education, product demonstration, product development, surgical technique discussions, anatomical demonstrations and biomechanical research. The synthetic bones consisting of cortical an cancellous bones containing a plastic casting resin, a pore inducing additive and a hardness-altering additive.

Abstract: A patient support apparatus includes a support structure having a patient support deck and a side rail coupled to the support structure. The side rail is movable relative to the support structure. A lock releasably locks the side rail in one or more side rail positions, such as in a raised position and an intermediate position. A manual release is coupled to the side rail and operable to unlock the side rail. A bypass lever is provided to allow a user to raise the side rail from a lowered position to the raised position without locking in the intermediate position. A damper is located inside the side rail to counterbalance the weight of the side rail and assist the user in raising the side rail, bi-directionally. The side rail is formed of first and second walls that are heat staked together to form a lightweight side rail of suitable strength.

Abstract: A method of modifying a driveline of a toy vehicle is provided. The first step involves disengaging a first end of an original drive shaft of the toy vehicle from a gearbox of the toy vehicle, where the gearbox is in a location such that it limits the travel of the suspension of the toy truck beuase it can come into contact with the differential. The second step involves disengaging a second end of the original drive shaft of the toy vehicle from a transfer box. The third step includes removing the original drive shaft from the toy vehicle. The fourth step involves dismounting the gearbox from the first and second longitudinal beams of the chassis. Next, the transfer box is dismounted from the first and second longitudinal beams of the chassis.

Abstract: Multispecific binding proteins that bind NKG2D receptor, CD16, and 5T4 are described, as well as pharmaceutical compositions, formulations, and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer.

Abstract: The present invention encompasses methods for reducing the number of target cells in a subject, such as cancer cells. The methods include administration of genetically-modified human immune cells expressing a chimeric antigen receptor or exogenous T cell receptor, which have specificity for an antigen on the target cells Administration of the genetically-modified immune cells can be preceded by the administration of a lymphodepletion region and/or an immunosuppression regimen, to improve efficacy of the therapy and persistence of the cells in vivo.

Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Abstract: The present invention encompasses methods for reducing the number of target cells in a subject, such as cancer cells. The methods include administration of genetically-modified human immune cells expressing a chimeric antigen receptor or exogenous T cell receptor, which have specificity for an antigen on the target cells. Administration of the genetically-modified immune cells is preceded by the administration of a tolerance regimen, followed by administration of a lymphodepletion regimen, to improve efficacy of the therapy and persistence of the cells in vivo.

Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: X1, X2, R1, R2, m and n are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, Parkinson's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Abstract: A system for construing a content presentation is disclosed. According to one embodiment, the system includes Input/Output (I/O) circuitry to receive an indicated location, and memory to store scheduling information that includes a location information and date information associated with the location information. A processor identifies at least one media segment for inclusion into a customized media programming stream based on (a) comparing the indicated location to the location information from the scheduling information; and (b) comparing the current date to the associated date information from the scheduling information. Further, the processer assembles a customized media programming stream by adding the at least one identified media segment to the customized media programming stream. The I/O circuitry transmits the customized media programming stream for presentation on a user device.