Abstract: Disclosed are compounds of formula (I) below or pharmaceutically acceptable salts thereof: in which each of variables R1-R6, L, m, and n is defined herein. Also disclosed are a method for treating an opioid receptor-associated condition with a compound of formula (I) and a pharmaceutical composition containing same.

Abstract: Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

Abstract: Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.

Abstract: A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

Abstract: Certain embodiments described herein are generally directed to enforcing application-specific quality of service (QoS) requirements over a storage network. The method for enforcing application-specific quality of service (QoS) requirements over a storage network includes receiving an input-output (I/O) command from a virtual machine executing an application, wherein the I/O command corresponds to an I/O request generated by the application and is tagged with a QoS classification corresponding to QoS requirements of the application, determining a QoS value corresponding to the QoS classification of the I/O command, and transmitting a data frame including the I/O command and the QoS value to a target network adapter through a switch fabric in a network, the switch fabric having a plurality of switches each configured to forward the data frame based on the QoS value.

Abstract: A nanoporous metal can be formed by projecting laser patterns using a spatial light modulator (SLM) onto a gold/silver alloy film immersed in diluted nitric acid solutions. Heat accumulation induced by the photothermal effect enables localized dealloying in dilute nitric acid. NPG micropatterns can be formed at the irradiated spots while the surrounding alloy remains intact.

Abstract: Memory management in a computer system may include allocating memory pages from a physical memory of the computer system to applications executing on the computer system. The memory pages may be associated with memory management tags. One or more memory pages may be identified for processing from the physical memory based on the memory management tags that the memory pages are associated with. The processed memory pages may then be designated as un-allocated memory pages for subsequent allocation to applications executing on the computing system.

Abstract: An isolated antibody, comprising a light-chain CDR1 (L-CDR1) having the sequence of SEQ ID NO: 1, SEQ ID NO: 7, or SEQ ID NO: 14; a light-chain CDR2 (L-CDR2) having the sequence of SEQ ID NO: 2 or SEQ ID NO: 15; a light-chain CDR3 (L-CDR3) having the sequence of SEQ ID NO: 3, SEQ ID NO: 8, SEQ ID NO: 21, or SEQ ID NO: 24; a heavy-chain CDR1 (H-CDR1) having the sequence of SEQ ID NO: 4, SEQ ID NO: 9, SEQ ID NO: 11, SEQ ID NO: 16, or SEQ ID NO: 25; a heavy-chain CDR2 (H-CDR2) having the sequence of SEQ ID NO: 5, SEQ ID NO: 12, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 22, or SEQ ID NO: 26; and a heavy-chain CDR3 (H-CDR3) having the sequence of SEQ ID NO: 6, SEQ ID NO: 10, SEQ ID NO: 13, SEQ ID NO: 18, SEQ ID NO: 20, SEQ ID NO: 23, or SEQ ID NO: 27, wherein the antibody specifically binds to A?1-42 or an N-terminal modified form thereof.

Abstract: This present invention disclosed a method for culturing Ophiocordyceps sinensis by inoculating a fungus inoculum onto a medium, culturing with a culturing condition in the dark room, and then culturing under the light for at least four weeks. According to the method for culturing O. sinensis disclosed in this present invention, the cultured O. sinensis has better growth rate and its composition and content of active ingredients are similar with wild O. sinensis.

Abstract: Certain embodiments described herein are generally directed to enforcing application-specific quality of service (QoS) requirements over a storage network. The method for enforcing application-specific quality of service (QoS) requirements over a storage network includes receiving an input-output (I/O) command from a virtual machine executing an application, wherein the I/O command corresponds to an I/O request generated by the application and is tagged with a QoS classification corresponding to QoS requirements of the application, determining a QoS value corresponding to the QoS classification of the I/O command, and transmitting a data frame including the I/O command and the QoS value to a target network adapter through a switch fabric in a network, the switch fabric having a plurality of switches each configured to forward the data frame based on the QoS value.

Abstract: Aminothiazole compounds of Formula (I) shown below and pharmaceutical compositions containing one of such compounds: Also disclosed are methods of inhibiting a tyrosine kinase and treating cancer associated with a tyrosine kinase with one of the aminothiazole compounds.

Abstract: Exemplary methods, apparatuses, and systems include a management server receiving, from each of a plurality of switches, physical topology data of network nodes. The physical topology data includes identifiers of hosts connected to each of the switches and identifiers of storage connected to each of the switches. The management server transmits a query to each of the network nodes and receives, in response to each query, the capabilities of each network node. In response to receiving a request to create a cluster of the hosts, the management server selects hosts and storage from the physical topology data to create the cluster. The hosts and storage are selected based upon the capabilities received from each network node. The management server determines transport protocol login service parameters based upon the received storage capabilities and transmits the parameters to one or more of the plurality of switches, hosts, and storage.

Abstract: A virtualization platform can discover capabilities of data devices connected in a virtual infrastructure. The virtualization platform allows a user (e.g., system administrator) to specify a policy profile for a virtual machine in terms of performance and data handling parameters. The virtualization platform can provision a virtual machine comprising data devices having a combined capability that matches the policy profile. Enforcement of a policy profile can be made when I/O is performed by a virtual machine.

Abstract: Disclosed are compounds of formula (I) below or pharmaceutically acceptable salts thereof: in which each of variables R1-R6, L, m, and n is defined herein. Also disclosed are a method for treating an opioid receptor-associated condition with a compound of formula (I) and a pharmaceutical composition containing same.

Abstract: A virtualization platform can discover capabilities of data devices connected in a virtual infrastructure. The virtualization platform allows a user (e.g., system administrator) to specify a policy profile for a virtual machine in terms of performance and data handling parameters. The virtualization platform can provision a virtual machine comprising data devices having a combined capability that matches the policy profile. Enforcement of a policy profile can be made when I/O is performed by a virtual machine.

Abstract: Aminothiazole compounds of Formula (I) shown below and pharmaceutical compositions containing one of such compounds: Also disclosed are methods of inhibiting a tyrosine kinase and treating cancer associated with a tyrosine kinase with one of the aminothiazole compounds.

Abstract: An optrode may provide a cylindrical substrate two or more electrodes deposited said cylindrical substrate. The cylindrical substrate and electrodes may be coated by an insulating layer with openings or vias over certain portions of the electrodes that may provide a contact for the neural probe or may be utilized to connect lead lines. Manufacturing of an optrode may utilize a jig that secures a cylindrical substrate coated by a conductive material and a resist. A first mask may be positioned in an opening provided by the jig, and the cylindrical substrate may be exposed ions or neutral particles to define one or more electrode patterns. After regions of the resist and conductive material are removed to form the electrodes, a second mask may be utilized to define vias regions in which portions of the electrodes are exposed and uncoated by an insulating layer.

Abstract: A virtualization platform can discover capabilities of data devices connected in a virtual infrastructure. The virtualization platform allows a user (e.g., system administrator) to specify a policy profile for a virtual machine in terms of performance and data handling parameters. The virtualization platform can provision a virtual machine comprising data devices having a combined capability that matches the policy profile. Enforcement of a policy profile can be made when I/O is performed by a virtual machine.

Abstract: A lithography-free, mold-free method of fabricating high quality optical material by curing polydimethylsiloxane (PDMS) droplets in or on pre-heated substrates allows lenses with different focal lengths to be made by varying the volume and surface temperature, as well as the substrate.

Abstract: Embodiments perform capability discovery, policy management, and policy enforcement to provide data in-flight (DIF) services to virtual machines (VMs) without requiring modification to established storage protocols. In exemplary embodiments, a management device receives advertisements of DIF services supported by network nodes. The management device groups the advertised DIF services into a DIF services policy. The management device associates a host and a communication path. The management device enforces the DIF services policy by storing a unique number that causes transmission of data along the communication path.