Abstract: A semiconductor device may include a metal pad and a first specific metal layer routing. The metal pad is positioned on a first metal layer of the semiconductor device and is directly contacting the first metal layer. The first specific metal layer routing is formed on a second metal layer of the semiconductor device and under the metal pad. In addition, the semiconductor device may include at least one via plug for connecting the first specific metal layer routing to at least one metal region in the first metal layer, where the aforementioned at least one via plug is formed directly under the metal pad.

Abstract: A method of forming a gate dielectric layer for a MOS transistor includes the following steps. A gate dielectric layer is formed on a substrate. A nitrdation process is performed on the gate dielectric layer. A multi-step post nitridation annealing process including two oxygen-containing annealing steps with different respective annealing temperatures is performed on the gate dielectric layer.

Abstract: A calibration method includes transmitting first data comprising a calibration data and a first checksum to the storage device according to each of a plurality of training parameter sets; recording a plurality of error indicators respectively which are corresponding to the plurality of training parameter sets and from the storage device; and identifying one of the plurality of training parameter sets as a predetermined parameter set according to the plurality of error indicators respectively corresponding to the plurality of training parameter sets; wherein each error indicator indicates whether transmitting the first data according to the corresponded training parameter set is successful.

Abstract: Certain embodiments are directed to methods of measuring single cell levels of biomarkers associated with prostate cancer.

Abstract: The present invention provides a biphenyl benzamide-derived derivatives, which structure is selected from formula I or formula II and the synthesis and the application thereof.

Abstract: The present invention provides a novel series of indeno[1,2-c]quinolin-11-one derivatives and further provides their preparation methods as well as applications. Said applications includes utilizing such derivatives as pharmaceutical compositions for treating cancers; moreover, said applications includes the capability possessed by such derivatives to effectively inhibit cancer cell growth as well as the activity of Type I topoisomerases and can be further applied for cancer treatment.

Abstract: The present invention provides a biphenyl benzamide-derived derivatives, which structure is selected from formula I or formula II and the synthesis and the application thereof.

Abstract: The present invention provides a pharmaceutical composition of salicylanilide-derived small molecules include: (a) a compound which structure is selected from formula I or formula II: (b) a pharmaceutically acceptable salt and excipient. The present invention also provides the synthesis method of the pharmaceutical composition and the application thereof.

Abstract: The present invention provides a biphenyl benzamide-derived derivatives, which structure is selected from formula I or formula II: and the synthesis and the application thereof.

Abstract: A clock generator includes a controllable clock source and a frequency hopping controller. The controllable clock source generates a clock signal to a clock-driven device. The frequency hopping controller controls the controllable clock source to make the clock signal have at least one frequency transition from one clock frequency to another clock frequency, wherein the controllable clock source stays in a frequency-locked state during a time period of the at least one frequency transition.

Abstract: The present invention provides a semiconductor device. The semiconductor device comprises: a metal pad and a first specific metal layer routing. The metal pad is positioned on a first metal layer of the semiconductor device. The first specific metal layer routing is formed on a second metal layer of the semiconductor device, and directly under the metal pad.

Abstract: An electronic device including a conductive element, a conductive layer, and a case is provided. The case has a surface, a first supporting member, and a second supporting member. The first supporting member and the second supporting member are disposed on the surface, and the first supporting member has a suspending arm. The case, the first supporting member and the second supporting member are integrally formed, and the conductive layer exists on the surface of the case, the first supporting member, and the second supporting member. The conductive element presses the first suspending arm to contact the second supporting member, such that a ground circuit is formed with the conductive element, the first suspending arm, the second supporting member, and the surface.

Abstract: A method of analyzing circulating tumor cells includes separating circulating tumor cells from a subject's blood sample by filtration; separating CD45-negative cells from any retained blood cells; and determining the EMT-related gene expression profiles, nanomechanical and/or nanochemical properties of the collected CD45-negative CTC cells. Analysis of the collected circulating tumor cells enables the investigators to make a quick and accurate assessment of the metastatic behavior of the subject's circulating tumor cells for early castration-resistance and metastasis prediction in a clinical setting.

Abstract: A USB device with a clock calibration function and a method for calibrating reference clocks of a USB device are provided. A USB 2.0 initial calibration is performed on the USB device in order to control an embedded oscillator (EMOSC) of the USB device to output a first reference clock compliance USB 2.0 specification and USB 3.0 specification during the initialization phase. After that, a USB 3.0 on-line calibration is performed on the USB device in order to control the EMOSC of the USB device to calibrate a second reference clock during a super-speed mode of USB 3.0 specification.

Abstract: A general receiver device with adaptive filter includes an antenna, a low noise amplifier, a bandpass tracking filter, a single-ended-to-differential converter unit, a mixer, and an adaptive filter. The antenna receives an RF signal. The low noise amplifier amplifies the RF signal for generating an amplified RF signal. The band-pass tracking filter filters the amplified RF signal for generating a filtered RF signal. The single-ended-to-differential converter unit converts the filtered RF signal into a differential RF signal. The mixer receives a differential local oscillation signal and uses the differential local oscillation signal to down-convert the differential RF signal into a differential IF signal. The adaptive filter filters the differential IF signal for generating a filtered differential IF signal.

Abstract: The present invention provides a biphenyl benzamide-derived derivatives, which structure is selected from formula I or formula II: and the synthesis and the application thereof.

Abstract: The present invention provides a pharmaceutical composition of salicylanilide-derived small molecules include: (a) a compound which structure is selected from formula I or formula II: (b) a pharmaceutically acceptable salt and excipient. The present invention also provides the synthesis method of the pharmaceutical composition and the application thereof.

Abstract: A frequency synthesis system with self-calibrated loop stability and bandwidth, which outputs an output signal based on an input signal and includes a detector, a charge pump, a filter, a controllable oscillator and a programmable frequency divider. The detector produces a detection signal based on a logic level difference between the input signal and a feedback signal. The charge pump is connected to the detector in order to produce a control signal based on the detection signal. The filter is connected to the charge pump in order to produce a tuning signal based on the control signal. The controllable oscillator is connected to the filter in order to produce the output signal based on the tuning signal. The programmable frequency divider is connected to the controllable oscillator in order to produce the feedback signal based on the output signal. The filter is a discrete time loop filter.

Abstract: A crank assembly for an acrobatic bicycle includes a mandrel, two cranks, a chainwheel, and a connector. The chainwheel has a shaft hole and a fixing hole. The connector has a mounting hole and a locking hole connected with the shaft hole and the fixing hole respectively. The mounting hole has a mounting portion inserted into the shaft hole. The mounting hole has an engaging surface. The mandrel has two urging portions, and one of the urging portions is extended through the mounting hole and is engaged with the engaging surface. Thus, the connector is connected with the chainwheel and located between the chainwheel, the mandrel and one of the cranks to enhance the structural strength of combination of the chainwheel, the mandrel and the two cranks.

Abstract: A roll-forming machine in which the left and right racks of each shape-forming roll set each have two guide blocks affixed thereto at two opposite sides in an opening thereof, each guide block having an oblique sliding slot, and left and right upper bearing blocks of each shape-forming roll set each have two sliding blocks respectively affixed to two opposite lateral sides thereof and respectively coupled to the oblique sliding slots of the guide blocks and movable upwards/downwards along the respective oblique sliding slots for adjustment of the feed gap between the upper shape-forming wheel set and lower shape-forming wheel set of the respective shape-forming roll set in X-axis and Y-axis directions at a time.