Patents by Inventor Colin Mitchinson

Colin Mitchinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CBH1 homologs and varian CBH1 cellulase
    Patent number: 8765440
    Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: July 1, 2014
    Assignee: Danisco US Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe
  • METHOD FOR REDUCING VISCOSITY IN SACCHARIFICATION PROCESS
    Publication number: 20140134677
    Abstract: The present invention relates to compositions that can be used in hydrolyzing biomass such as compositions comprising a polypeptide having glycosyl hydrolase family 61/endoglucanase activity, methods for hydrolyzing biomass material, and methods for reducing viscosity of biomass mixture using a composition comprising a polypeptide having glycosyl hydrolase family 61/endoglucanase activity.
    Type: Application
    Filed: March 16, 2012
    Publication date: May 15, 2014
    Applicant: DANISCO US INC.
    Inventors: Colin Mitchinson, Mian Li, Bradley R. Kelemen, Suzanne E. Lantz, Keith D. Wing, William D. Hitz
  • Variant CBH2 cellulases
    Patent number: 8715997
    Abstract: Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: May 6, 2014
    Assignee: Danisco US Inc.
    Inventors: Wolfgang Aehle, Frits Goedegebuur, Lydia Dankmeyer, Colin Mitchinson, Paulien Neefe, Bradley Kelemen, Robert Caldwell, Pauline Teunissen
  • GLYCOSYL HYDROLASE ENZYMES AND USES THEREOF FOR BIOMASS HYDROLYSIS
    Publication number: 20140106408
    Abstract: The present invention relates to compositions that can be used in hydrolyzing biomass such as compositions comprising a polypeptide having glycosyl hydrolase (GH) family 61/endoglucanase activity and/or a ?-glucosidase polypeptide, methods for hydrolyzing biomass material, and methods for using such compositions.
    Type: Application
    Filed: March 16, 2012
    Publication date: April 17, 2014
    Applicant: DANISCO US INC.
    Inventors: Colin Mitchinson, Steven S. Kim, Meredith K. Fujdala, Megan Y. Hsi, Keith D. Wing, William D. Hitz
  • ALTERING ENZYME BALANCE THROUGH FERMENTATION CONDITIONS
    Publication number: 20140099677
    Abstract: This present disclosure relates to methods for improved production of proteins from a cell culture, particularly to culture components and conditions that can preferentially increase the expression of proteins produced from genes under the control of xylanase gene promoter sequences. The improved methods can be used for the production of enzyme compositions with enhanced xylanase and hem icellulolytic activity.
    Type: Application
    Filed: August 15, 2013
    Publication date: April 10, 2014
    Applicant: Danisco US Inc.
    Inventors: Aaron KELLEY, Chuanbin LIU, Colin MITCHINSON
  • Variant CBH1 cellulase
    Patent number: 8679817
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: March 25, 2014
    Assignee: Danisco US Inc.
    Inventors: Anthony Day, Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe-Kruithof, Mats Sandgren, Andrew Shaw, Jerry Stahlberg
  • Variant CBH1.1
    Patent number: 8673611
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: March 18, 2014
    Assignee: Danisco US Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • Process for simultaneous saccharification and fermentation for production of ethanol
    Patent number: 8647850
    Abstract: Methods are disclosed for the production of high concentrations of ethanol from biomass using Zymomonas as the ethanologen. Zymomonas is grown under conditions of low impeller agitation with high concentration of insoluble solids in a saccharification-fermentation mixture during a simultaneous saccharification and fermentation reaction for the production of high concentrations of ethanol.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 11, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: William D. Hitz, Tom Huang, Amanda Kathleen Iverson, Brian G. Lefebvre, Colin Mitchinson
  • Variant CBH1 cellulases
    Patent number: 8637294
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: January 28, 2014
    Assignee: Danisco US Inc.
    Inventors: Anthony Day, Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe, Mats Sandgren, Andrew Shaw, Jerry Stahlberg
  • METHOD FOR IMPROVING YIELD OF CELLULOSE CONVERSION PROCESSES
    Publication number: 20140011242
    Abstract: The present teachings provide methods of converting cellulosic materials to soluble sugars. Methods for increasing the yield of glucose from the enzymatic saccharification of cellulosic materials is also provided. The present teachings further provide methods of increasing the yield of cellobiose from the enzymatic saccharification of cellulosic materials.
    Type: Application
    Filed: June 13, 2013
    Publication date: January 9, 2014
    Applicant: Danisco US Inc.
    Inventors: Bradley R. KELEMEN, Edmund A. LARENAS, Colin MITCHINSON
  • VARIANT HUMICOLA GRISEA CBH1.1
    Publication number: 20130244289
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Application
    Filed: January 17, 2013
    Publication date: September 19, 2013
    Applicant: DANISCO US INC.
    Inventors: Frits GOEDEGEBUUR, Peter GUALFETTI, Colin MITCHINSON, Edmund LARENAS
  • Altering enzyme balance through fermentation conditions
    Patent number: 8530193
    Abstract: This present disclosure relates to methods for improved production of proteins from a cell culture, particularly to culture components and conditions that can preferentially increase the expression of proteins produced from genes under the control of xylanase gene promoter sequences. The improved methods can be used for the production of enzyme compositions with enhanced xylanase and hemicellulolytic activity.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: September 10, 2013
    Assignee: Danisco US Inc.
    Inventors: Aaron Kelley, Chuanbin Liu, Colin Mitchinson
  • NOVEL GLYCOSYL HYDROLASE ENZYMES AND USES THEREOF
    Publication number: 20130177947
    Abstract: The present disclosure is generally directed to glycosyl hydrolase enzymes, compositions comprising such enzymes, and methods of using the enzymes and compositions, for example for the saccharification of cellulosic and hemicellulosic materials into sugars.
    Type: Application
    Filed: September 22, 2010
    Publication date: July 11, 2013
    Applicant: DANISCO US INC.
    Inventors: Benjamin Bower, Megan Yee Hsi, Thijs Kaper, Bradley R. Keleman, Suzanne E. Lantz, Edmund A. Larenas, Colin Mitchinson, Steven Kim, William D. Hitz, Mark Emptage, Keith Dumont Wing
  • Methods for Improving the Efficiency of Simultaneous Saccharification and Fermentation Reactions
    Publication number: 20130143277
    Abstract: The present disclosure is directed, in a first aspect, to the use of inverting beta-xylosidase enzymes to reduce byproduct formation and increase the yield of fermentation products, as well as, in a second aspect, to the use of retaining beta-xylosidase enzymes to improve production of alkyl-beta-xylopyranoside compounds, in a simultaneous saccharification and fermentation reactions.
    Type: Application
    Filed: December 17, 2010
    Publication date: June 6, 2013
    Applicant: DANISCO US INC.
    Inventors: Christina Gutierrez, Colin Mitchinson, Tom T. Huang, Bruce A. Diner, Paul Joseph Fagan, William D. Hitz
  • Variant CBH1.1
    Patent number: 8377659
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: February 19, 2013
    Assignee: Danisco US Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • USE OF CELLULASE AND GLUCOAMYLASE TO IMPROVE ETHANOL YIELDS FROM FERMENTATION
    Publication number: 20120276593
    Abstract: An improved saccharification process comprises the use of a glucoamylase and at least one cellulase. The improved saccharification process results in improved yields of fermentations products, such as ethanol. In one embodiment, the improved saccharification process results in an increased yield of up to 0.5% to 1% ethanol using commercially available cellulases. Also provided are improved simultaneous saccharification and fermentation (SSF) processes, and compositions comprising a liquefied starch slurry, a glucoamylase, and a cellulase.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Applicant: Danisco US Inc.
    Inventors: Mian Li, Colin Mitchinson
  • VARIANT HUMICOLA GRISEA CBH1.1
    Publication number: 20120270270
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Application
    Filed: July 5, 2012
    Publication date: October 25, 2012
    Applicant: DANISCO US INC.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • NOVEL VARIANT HYPROCREA JECORINA CBH1 CELLULASES
    Publication number: 20120270298
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Application
    Filed: June 14, 2012
    Publication date: October 25, 2012
    Applicants: GENENCOR INTERNATIONAL, INC., DANISCO US INC.
    Inventors: Anthony Day, Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe, Mats Sandgren, Andrew Shaw, Jerry Stahlberg
  • Variant CBH1.1
    Patent number: 8236546
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: August 7, 2012
    Assignee: Danisco US Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • Variant CBH1 cellulases
    Patent number: 8232080
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: July 31, 2012
    Assignee: Danisco US Inc.
    Inventors: Anthony Day, Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe, Mats Sandgren, Andrew Shaw, Jerry Stahlberg