Patents by Inventor Colin Mitchinson

Colin Mitchinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Induction of Gene Expression Using a High Concentration Sugar Mixture
    Publication number: 20100009408
    Abstract: Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.
    Type: Application
    Filed: July 6, 2009
    Publication date: January 14, 2010
    Inventors: George R. England, Aaron Kelley, Colin Mitchinson
  • Variant humicola Grisea CBH1.1
    Publication number: 20090233335
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Application
    Filed: July 6, 2007
    Publication date: September 17, 2009
    Applicant: Genencor International, Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • Novel CBH1 Homologs And Variant CBH1 Cellulases
    Publication number: 20090163397
    Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
    Type: Application
    Filed: October 13, 2008
    Publication date: June 25, 2009
    Inventors: FRITS GOEDEGEBUUR, PETER GUALFETTI, COLIN MITCHINSON, PAULIEN NEEFE
  • Variant Humicola Grisea CBH1.1
    Publication number: 20090075336
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Application
    Filed: October 28, 2008
    Publication date: March 19, 2009
    Applicant: Genencor International, Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • Variant EGIII-like cellulase compositions
    Patent number: 7501272
    Abstract: The present invention relates to novel variant EGIII or EGIII-like cellulases that have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: March 10, 2009
    Assignee: Danisco US Inc., Genencor Division
    Inventors: Peter Gualfetti, Colin Mitchinson, Jay Phillips
  • Variant CBH1.1
    Patent number: 7459299
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: December 2, 2008
    Assignee: Danisco A/S, Genencor Division
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • CBH1 homologs and variant CBH1 cellulases
    Patent number: 7452707
    Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
    Type: Grant
    Filed: March 19, 2004
    Date of Patent: November 18, 2008
    Assignee: Danisco A/S, Genencor Division
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe
  • Novel variant hypocrea jercorina CBH1 cellulases
    Publication number: 20070173431
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Application
    Filed: March 22, 2007
    Publication date: July 26, 2007
    Inventors: Anthony Day, Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe, Mats Sandgren, Andrew Shaw, Jerry Stahlberg
  • Novel variant hypocrea jecorina CBH2 cellulases
    Publication number: 20060205042
    Abstract: Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.
    Type: Application
    Filed: December 22, 2005
    Publication date: September 14, 2006
    Inventors: Wolfgang Aehle, Frits Goedegebuur, Lydia Dankmeyer, Colin Mitchinson, Paulien Neefe, Bradley Kelemen, Robert Caldwell, Pauline Teunissen
  • Variant EGIII-like cellulase compositions
    Patent number: 7094588
    Abstract: The present invention relates to novel variant EGIII or EGIII-like cellulases that have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: August 22, 2006
    Assignee: Genencor International, Inc.
    Inventors: Peter Gualfetti, Colin Mitchinson, Jay Phillips
  • Exo-endo cellulase fusion protein
    Publication number: 20060057672
    Abstract: The present invention relates to a heterologous exo-endo cellulase fusion construct, which encodes a fusion protein having cellulolytic activity comprising a catalytic domain derived from a fungal exo-cellobiohydrolase and a catalytic domain derived from an endoglucanase. The invention also relates to vectors and fungal host cells comprising the heterologous exo-endo cellulase fusion construct as well as methods for producing a cellulase fusion protein and enzymatic cellulase compositions.
    Type: Application
    Filed: March 23, 2005
    Publication date: March 16, 2006
    Inventors: Benjamin Bower, Edmund Larenas, Colin Mitchinson
  • Novel variant hypocrea jecorina CBH1cellulases
    Publication number: 20050277172
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Application
    Filed: August 15, 2003
    Publication date: December 15, 2005
    Applicant: Genencor International, Inc.
    Inventors: Anthony Day, Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe, Mats Sandgren, Andrew Shaw, Jerry Stahlberg
  • Novel CBH1 homologs and variant CBH1 cellulases
    Publication number: 20050054039
    Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
    Type: Application
    Filed: March 19, 2004
    Publication date: March 10, 2005
    Applicant: Genencor International, Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe
  • Variant humicola grisea CBH1.1
    Publication number: 20050037459
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Application
    Filed: March 26, 2004
    Publication date: February 17, 2005
    Applicant: Genencor International, Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • Induction of gene expression using a high concentration sugar mixture
    Publication number: 20040121446
    Abstract: Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.
    Type: Application
    Filed: September 10, 2003
    Publication date: June 24, 2004
    Applicant: Genencor International, Inc.
    Inventors: George R. England, Aaron Kelley, Colin Mitchinson
  • Novel variant EGIII-like cellulase compositions
    Publication number: 20030203467
    Abstract: The present invention relates to novel variant EGIII or EGIII-like cellulases that have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability.
    Type: Application
    Filed: May 19, 2003
    Publication date: October 30, 2003
    Inventors: Peter Gualfetti, Colin Mitchinson, Jay Phillips
  • Mutant EGIII cellulase, DNA encoding such EGIII compositions and methods for obtaining same
    Patent number: 6635465
    Abstract: The present invention relates to variant EGIII cellulases that have improved stability and/or performance. The variant cellulases have replacements at sensitive residues to improve stability and/or performance.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: October 21, 2003
    Assignee: Genencor International, Inc.
    Inventors: Peter Gualfetti, Colin Mitchinson, Traci H. Ropp
  • Novel variant EGIII-like cellulase compositions
    Publication number: 20030186418
    Abstract: The present invention relates to novel variant EGIII or EGIII-like cellulases that have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability.
    Type: Application
    Filed: May 19, 2003
    Publication date: October 2, 2003
    Inventors: Peter Gualfetti, Colin Mitchinson, Jay Phillips
  • Variant EGIII-like cellulase compositions
    Patent number: 6623949
    Abstract: The present invention relates to novel variant EGIII or EGIII-like cellulases that have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability.
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: September 23, 2003
    Assignee: Genencor International, Inc.
    Inventors: Peter Gualfetti, Colin Mitchinson, Jay Phillips
  • Mutant EGIII cellulase, DNA encoding such EGIII compositions and methods for obtaining same
    Patent number: 6582750
    Abstract: The present invention relates to variant EGIII cellulases that have improved stability and/or performance. The variant cellulases have replacements at sensitive residues to improve stability and/or performance.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: June 24, 2003
    Assignee: Genencor International, Inc.
    Inventors: Timothy Fowler, Colin Mitchinson