Patents by Inventor Colin Mitchinson

Colin Mitchinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXO-ENDO CELLULASE FUSION PROTEIN
    Publication number: 20120135499
    Abstract: The present invention relates to a heterologous exo-endo cellulase fusion construct, which encodes a fusion protein having cellulolytic activity comprising a catalytic domain derived from a fungal exo-cellobiohydrolase and a catalytic domain derived from an endoglucanase. The invention also relates to vectors and fungal host cells comprising the heterologous exo-endo cellulase fusion construct as well as methods for producing a cellulase fusion protein and enzymatic cellulase compositions.
    Type: Application
    Filed: November 7, 2011
    Publication date: May 31, 2012
    Applicant: Danisco US Inc.
    Inventors: Benjamin S. Bower, Edmund A. Larenas, Colin Mitchinson
  • Altering Enzyme Balance Through Fermentation Conditions
    Publication number: 20120064579
    Abstract: This present disclosure relates to methods for improved production of proteins from a cell culture, particularly to culture components and conditions that can preferentially increase the expression of proteins produced from genes under the control of xylanase gene promoter sequences. The improved methods can be used for the production of enzyme compositions with enhanced xylanase and hemicellulolytic activity.
    Type: Application
    Filed: April 30, 2010
    Publication date: March 15, 2012
    Inventors: Aaron Kelley, Chuanbin Liu, Colin Mitchinson
  • Novel Variant Hypocrea Jecorina CBH2 Cellulases
    Publication number: 20120040435
    Abstract: Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.
    Type: Application
    Filed: July 7, 2011
    Publication date: February 16, 2012
    Applicant: Danisco US Inc.
    Inventors: Wolfgang Aehle, Frits Goedegebuur, Lydia Dankmeyer, Colin Mitchinson, Paulien Neefe, Bradley Kelemen, Robert Caldwell, Pauline Teunissen
  • Exo-endo cellulase fusion protein
    Patent number: 8097445
    Abstract: The present invention relates to a heterologous exo-endo cellulase fusion construct, which encodes a fusion protein having cellulolytic activity comprising a catalytic domain derived from a fungal exo-cellobiohydrolase and a catalytic domain derived from an endoglucanase. The invention also relates to vectors and fungal host cells comprising the heterologous exo-endo cellulase fusion construct as well as methods for producing a cellulase fusion protein and enzymatic cellulase compositions.
    Type: Grant
    Filed: March 23, 2005
    Date of Patent: January 17, 2012
    Assignee: Danisco US Inc.
    Inventors: Benjamin S. Bower, Edmund A. Larenas, Colin Mitchinson
  • PROCESS FOR SIMULTANEOUS SACCHARIFICATION AND FERMENTATION FOR PRODUCTION OF ETHANOL
    Publication number: 20110318803
    Abstract: Methods are disclosed for the production of high concentrations of ethanol from biomass using Zymomonas as the ethanologen. Zymomonas is grown under conditions of low impeller agitation with high concentration of insoluble solids in a saccharification-fermentation mixture during a simultaneous saccharification and fermentation reaction for the production of high concentrations of ethanol.
    Type: Application
    Filed: December 17, 2010
    Publication date: December 29, 2011
    Applicant: E. I. Du Pont De Nemours and Company
    Inventors: William D. Hitz, Tom Huang, Amanda Kathleen Iverson, Brian G. Lefebvre, Colin Mitchinson
  • VARIANT HUMICOLA GRISEA CBH1.1
    Publication number: 20110294164
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Application
    Filed: April 21, 2011
    Publication date: December 1, 2011
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • VARIANT HUMICOLA GRISEA CBH1.1
    Publication number: 20110294165
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Application
    Filed: April 21, 2011
    Publication date: December 1, 2011
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • Novel Variant Hyprocrea Jecorina CBH1 Cellulases
    Publication number: 20110229956
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Application
    Filed: May 13, 2011
    Publication date: September 22, 2011
    Applicants: Danisco US Inc., Genencor International, Inc.
    Inventors: Anthony Day, Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe, Mats Sandgren, Andrew Shaw, Jerry Stahlberg
  • Variant CBH2 cellulases
    Patent number: 8008056
    Abstract: Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: August 30, 2011
    Assignee: Danisco US Inc.
    Inventors: Wolfgang Aehle, Frits Goedegebuur, Lydia Dankmeyer, Colin Mitchinson, Paulien Neefe, Brad Kelemen, Robert Caldwell, Pauline Teunissen
  • Induction of Gene Expression Using a High Concentration Sugar Mixture
    Publication number: 20110207913
    Abstract: Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.
    Type: Application
    Filed: February 17, 2011
    Publication date: August 25, 2011
    Inventors: George R. England, Aaron Kelley, Colin Mitchinson
  • Variant CBH1.1
    Patent number: 7998711
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: August 16, 2011
    Assignee: Danisco US Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • Novel CBH1 Homologs And Varian CBH1 Cellulase
    Publication number: 20110177561
    Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
    Type: Application
    Filed: March 25, 2011
    Publication date: July 21, 2011
    Applicant: Danisco US Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe
  • Variant CBH1 cellulases
    Patent number: 7972832
    Abstract: Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
    Type: Grant
    Filed: August 15, 2003
    Date of Patent: July 5, 2011
    Assignee: Danisco US Inc.
    Inventors: Anthony Day, Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe, Mats Sandgren, Andrew Shaw, Jerry Stahlberg
  • SWOLLENIN COMPOSITIONS AND METHODS OF INCREASING THE EFFICIENCY OF A CELLULASE
    Publication number: 20110136182
    Abstract: Described are compositions and methods relating to enhancing the efficiency of cellulases for sugar production from cellulosic biomass using the polypeptide swollenin.
    Type: Application
    Filed: April 29, 2009
    Publication date: June 9, 2011
    Applicant: DANISCO US INC.
    Inventors: Tom Tao Huang, Colin Mitchinson, Rafael F. Sala
  • Variant CBH1.1
    Patent number: 7951571
    Abstract: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: May 31, 2011
    Assignee: Danisco US Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Edmund Larenas
  • CBH1 homologs and variant CBH1 cellulases
    Patent number: 7951570
    Abstract: Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: May 31, 2011
    Assignee: Danisco US Inc.
    Inventors: Frits Goedegebuur, Peter Gualfetti, Colin Mitchinson, Paulien Neefe
  • Methods and Compositions for Enhanced Production of Organic Substances From Fermenting Microorganisms
    Publication number: 20110039320
    Abstract: The present invention relates methods and compositions for producing an organic substance from fermenting microorganism using simultaneous saccharification and fermentation.
    Type: Application
    Filed: October 9, 2008
    Publication date: February 17, 2011
    Inventors: Mian Li, Colin Mitchinson, Landon M. Steele
  • Induction of gene expression using a high concentration sugar mixture
    Patent number: 7713725
    Abstract: Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: May 11, 2010
    Assignee: Danisco US Inc.
    Inventors: George R. England, Aaron Kelley, Colin Mitchinson
  • Novel Variant EGIII-Like Cellulase Compositions
    Publication number: 20100087353
    Abstract: The present invention relates to novel variant EGIII or EGIII-like cellulases that have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability.
    Type: Application
    Filed: January 27, 2009
    Publication date: April 8, 2010
    Inventors: Peter Gualfetti, Colin Mitchinson, Jay Phillips
  • Method for Improving Yield of Cellulose Conversion Processes
    Publication number: 20100055747
    Abstract: The present teachings provide methods of converting cellulosic materials to soluble sugars. Methods for increasing the yield of glucose from the enzymatic saccharification of cellulosic materials is also provided. The present teachings further provide methods of increasing the yield of cellobiose from the enzymatic saccharification of cellulosic materials.
    Type: Application
    Filed: November 13, 2007
    Publication date: March 4, 2010
    Inventors: Bradley Kelemen, Edmund A. Larenas, Colin Mitchinson