Abstract: At least one proof transaction for recording on a blockchain comprises at least an s-part for an Elliptic Curve Digital Signature Algorithm, ECDSA, signature. The s-part is computed from a set of signature components, each provided by a participant of a signing subset of a set of keyshare participants. Each of keyshare participant holds an ephemeral keyshare of an unknown ephemeral key, and each of the signing components is provided by the participant of the signing subset based on their ephemeral keyshare. The at least one proof transaction indicates an r-challenge of at least one challenge transaction, and a node of a blockchain network applies signature verification to: (i) the s-part of the at least one proof transaction, and (ii) one of: (iia) an r-part of the r-challenge, (iib) an r-part of the at least one proof transaction, and in that event checks that that r-part satisfies the r-challenge.

Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.

Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: A cover for an ultrasound scanning assembly is provided, wherein the cover exerts compressive force on the patient during use. The cover includes an outer frame and a nonporous or porous film extending across the outer frame. The outer frame is formed of a soft touch material.

Abstract: Embodiments of the invention are directed to a system, method, or computer program product for cross-channel network security with tiered adaptive mitigation operations. In this regard, the invention is structured for dynamic detection of security events associated with network devices and resources, and triggering real-time mitigation operations across a plurality of resource channels. The invention provides a novel method for employing activity data to construct and implement mitigation actions for de-escalating authorization tiers that are adapted to the specific attributes of the activity data, in order to prevent security exposure associated with the activity. Another aspect of the invention is directed to determining whether to continue the tiered adaptive mitigation actions and/or trigger a security proceed signal.

Abstract: An implementation of the present application provides a computer-implemented method to increase the security of a blockchain-implemented transaction, the transaction including participation from a plurality of participating nodes, each participating node participating as a message originator, selector, and propagator. The method, implemented at a participating node, includes: receiving ciphertext from a prior node and determining whether the participating node is a selector node for said ciphertext received from the prior node. When the participating node is the selector node for said ciphertext, the method includes selecting a subset of said ciphertext, decrypting the selected subset of said ciphertext to provide opted ciphertext and transmitting said opted ciphertext to the next node. When the participating node is other than the selector node for said ciphertext, the method includes decrypting said ciphertext received from the prior node and transmitting the decrypted ciphertext to the next node.

Abstract: A puncture device guide includes a body member configured to fixedly attach to an ultrasound probe, a slide member slidingly received within the body member; and a cradle member slidingly received within the slide member and longitudinally fixed relative to the body member. The cradle member is configured to receive a puncture device therein. Longitudinal movement of the slide member causes radial movement of the cradle member relative to the body member.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: A system and computer-implemented method detect and act upon operator reliance to vehicle alerts. The system and method include receiving user profile data of an operator that includes a baseline of at least one driving activity aided by activation of an alert from a feature of an Advanced Driver Assistance System (ADAS). The system and method may include receiving historical ADAS alert frequency data including a history of at least one driving activity aided by activation of the alert from the ADAS feature. The system and method may compare the user profile data with the historical ADAS alert frequency data, determine a reliance level based upon the comparing, and set at least a portion of an operator profile associated with the operator with the reliance level. As a result, a risk averse driver, and/or proper responsiveness to vehicle alerts may be rewarded with insurance-cost savings, such as increased discounts.

Abstract: A system is provided for performing transaction mixing between a plurality of users on a blockchain. The system is configured to carry out the steps of: selecting an initiator node to calculate a deterministic hash function using a chosen random number; distribute the deterministic hash function to a plurality of users on the blockchain; choose an amount of time each user is given to construct a payment channel, retrieve the random number, and submit an execution transaction to a blockchain network; choose a second time for when a payment to a user is submitted to the blockchain network; and establish a one-way payment channel between every pair of users in an ordered set of the plurality of users to establish a transaction chain linking all users.

Abstract: A puncture device guide comprises a guide body member configured to fixedly attach to an ultrasound probe and a lock assembly coupled to the guide body to fix the guide body relative to the ultrasound probe. The guide body member comprises a guide tube having a central aperture extending therethrough for receiving a puncture device; a forward securing member for engaging a forward portion of the ultrasound probe; and a rearward securing member for engaging a rearward portion of the ultrasound probe. The lock assembly is configured to be moveably coupled to the guide body member between a locked configuration and an unlocked configuration.

Abstract: A spray tip comprises a tip body, a tip piece, and a pre-orifice piece. The tip body has a fluid channel along a channel axis (AC). The tip piece is disposed within the fluid channel, and has a stepped, narrowing passage that terminates in an outlet orifice. The pre-orifice piece has an inlet passage, and is disposed within the fluid channel, abutting and immediately upstream of the tip piece. The pre-orifice piece and the tip piece together define a turbulating chamber therebetween.

Abstract: Genes found in wild species can provide beneficial traits to domestic crops. For example, wild Glycine species can provide resistance to a broad spectrum of soy rust populations if introgressed into soybean. Previously, successful introgression required wide cross pollinations, embryo rescue, and regeneration of F1 shoots. Furthermore, chromosome doubling, which can be achieved by chemical treatment of embryos, was required in order to obtain fertile amphidiploids (F1Ds). A backcross to soybean was then required in order to obtain BC1F1 genetics. Here we describe improved procedures for interspecific crosses between soybean and Glycine tomentella. These procedures offer a more efficient route to BC1F1 genetics by bypassing the amphidiploid generation. These principles can be applied to additional domestic species and their wild relatives such as Brassica.

Abstract: Some embodiments of the disclosure include disclosed compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the disclosed compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.). Additional embodiments provide disease treatment using combinations of the disclosed IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: A guidance device is provided for facilitating the placement of a puncture device (a needle) at a defined position relative to an ultrasound probe. The guidance device provides additional support of a needle tip near the needle injection site to maintain a selected path throughout an injection. The additional support is automatically retracted for simple disposal with the used syringe after an injection. The guidance device minimizes contact of soiled components and enables syringe insertion, alignment, and removal for multiple different injections without removal of an ultrasound probe from the patient.

Abstract: An enclosure or housing for an air monitoring instrument package for mounting on the roof or other surface on the outside of vehicles such as cars, trucks, buses, trams, trains and ships. By measuring air pollutants from moving vehicles, it is possible to explore the distribution of air pollutants throughout a city or rural area for the identification of sources of different pollutants, estimating human exposures to air pollutants, and mapping air pollutants with high resolution. The disclosed device provides continuous sampling of outside air while simultaneously protecting the delicate instruments from weather elements such as high wind, rain, snow, sleet and hail. The design also allows a nearly constant flow rate of sampled air independent of vehicle velocity. An optional impaction region further reduces transmission of mist and large particles to the chamber containing the measurement package.

Abstract: The disclosure provides salts of (2R,6R)-hydroxynorketamine (HNK), wherein the salt is with an organic acid chosen from malonic acid, salicylic acid, ethane sulfonic acid, glycolic acid, stearic acid, or capric acid, and their crystal forms.

Abstract: A puncture device guide includes a body member configured to fixedly attach to an ultrasound probe, a slide member slidingly received within the body member; and a cradle member slidingly received within the slide member and longitudinally fixed relative to the body member. The cradle member is configured to receive a puncture device therein. Longitudinal movement of the slide member causes radial movement of the cradle member relative to the body member.