Abstract: Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I), (II), or (III)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.). Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: A computing system fits a long-term utilization line through aggregate utilization values that correspond to ones of a plurality of intervals over a time period. The computing system determines, for each respective interval of/ordinal intervals in each second time period within the time period, a mean residual value based on a difference between a utilization value identified on the long-term utilization line at the respective interval and an actual aggregate utilization value at a same ordinal interval in each second time period. An aggregate probability value, based in part on a probability that a cable modem of a plurality of cable modems can obtain at one or more intervals a maximum bandwidth allocated to the cable modem, is determined, and in response to determining that the aggregate probability value is a non-preferred value, an alert, indicating that the service group is overutilized, is sent.

Abstract: A guidance device is provided for facilitating the placement of a puncture device (a needle) at a defined position relative to an ultrasound probe. The guidance device provides additional support of a needle tip near the needle injection site to maintain a selected path throughout an injection. The additional support is automatically retracted for simple disposal with the used syringe after an injection. The guidance device minimizes contact of soiled components and enables syringe insertion, alignment, and removal for multiple different injections without removal of an ultrasound probe from the patient.

Abstract: A power amplifier impedance adjustment circuit is disclosed. In one aspect, the impedance adjustment circuit includes an input node configured to receive a radio frequency (RF) signal from a power amplifier, an output node configured to provide the RF signal to an antenna switch die, a plurality of electrical components arranged between the input node and the output node, and at least one switch configured to selectively electrically connect at least one of the electrical components to the input node and the output node. For each state of the at least one switch, the impedance adjustment circuit is configured to adjust an impedance of the power amplifier from a natural tune point in a direction towards a target tuned impedance point when viewed on a Smith chart.

Abstract: A computing system accesses actual aggregate service group utilization values that correspond to ones of a plurality of intervals over a first period of time and that identify an aggregate service group bandwidth utilization by cable modems in a service group at a plurality of intervals, the first period of time including multiple second periods of time having a same time duration, each second period of time having I ordinal intervals, and estimated aggregate service group utilization values that correspond to the actual aggregate service group utilization values. The computing system determines an additional bandwidth quantity for the service group such that an aggregate probability over a predetermined period of time that the plurality of cable modems will exceed a current provisioned bandwidth of the service group and the additional bandwidth quantity is within a desired probability range. A computing system sends, to a destination, the additional bandwidth quantity.

Abstract: A needle guide to retain a needle at a desired trajectory with respect to an imaging transducer includes a body member, a needle holder subassembly, and a slide member. The needle holder subassembly is pivotably mounted on the body member to enable the needle holder subassembly to be oriented to various selected orientations with respect to the body member. The slide member is slidably coupled to each of the body member and the needle holder subassembly, such that movement of the slide member relative to the body member moves the needle holder subassembly between the various selected orientations.

Abstract: A method of adjusting an impedance of a power amplifier of a radio frequency system for matching with an antenna switch die is disclosed. In one aspect, the method includes connecting the power amplifier to the antenna switch die via an impedance adjustment circuit, the impedance adjustment circuit including an input node, an output node, a plurality of electrical components arranged between the input node and the output node, and at least one switch configured to selectively electrically connect at least one of the electrical components to the input node and the output node. The method further includes determining an Error Vector Magnitude of the radio frequency system for each of a plurality of states of the at least one switch, and controlling the at least one switch to enter the state of the plurality of states that minimizes the Error Vector Magnitude of the radio frequency system.

Abstract: A disposable puncture device guide for use with an ultrasound probe is described. The puncture device guide includes a fixed portion configured to attach directly or indirectly to the probe body and a deflection portion connected to the fixed portion by at least one living hinge. The deflection portion comprises at least one groove configured support a puncture device therein. Outward pressure on the at least one groove causes the deflection portion to rotate outwardly relative to the fixed portion to support the puncture device throughout a range of angles.

Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: A cover for an ultrasound scanning assembly is provided, wherein the cover exerts compressive force on the patient during use. The cover includes an outer frame and a nonporous or porous film extending across the outer frame. The outer frame is formed of a soft touch material.

Abstract: A puncture device guide includes a body member configured to fixedly attach to an ultrasound probe, a slide member slidingly received within the body member; and a cradle member slidingly received within the slide member and longitudinally fixed relative to the body member. The cradle member is configured to receive a puncture device therein. Longitudinal movement of the slide member causes radial movement of the cradle member relative to the body member.

Abstract: A puncture device guide comprises a guide body member configured to fixedly attach to an ultrasound probe and a lock assembly coupled to the guide body to fix the guide body relative to the ultrasound probe. The guide body member comprises a guide tube having a central aperture extending therethrough for receiving a puncture device; a forward securing member for engaging a forward portion of the ultrasound probe; and a rearward securing member for engaging a rearward portion of the ultrasound probe. The lock assembly is configured to be moveably coupled to the guide body member between a locked configuration and an unlocked configuration.

Abstract: A spray tip comprises a tip body, a tip piece, and a pre-orifice piece. The tip body has a fluid channel along a channel axis (AC). The tip piece is disposed within the fluid channel, and has a stepped, narrowing passage that terminates in an outlet orifice. The pre-orifice piece has an inlet passage, and is disposed within the fluid channel, abutting and immediately upstream of the tip piece. The pre-orifice piece and the tip piece together define a turbulating chamber therebetween.

Abstract: Some embodiments of the disclosure include disclosed compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the disclosed compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.). Additional embodiments provide disease treatment using combinations of the disclosed IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: Genes found in wild species can provide beneficial traits to domestic crops. For example, wild Glycine species can provide resistance to a broad spectrum of soy rust populations if introgressed into soybean. Previously, successful introgression required wide cross pollinations, embryo rescue, and regeneration of F1 shoots. Furthermore, chromosome doubling, which can be achieved by chemical treatment of embryos, was required in order to obtain fertile amphidiploids (F1Ds). A backcross to soybean was then required in order to obtain BC1F1 genetics. Here we describe improved procedures for interspecific crosses between soybean and Glycine tomentella. These procedures offer a more efficient route to BC1F1 genetics by bypassing the amphidiploid generation. These principles can be applied to additional domestic species and their wild relatives such as Brassica.

Abstract: A guidance device is provided for facilitating the placement of a puncture device (a needle) at a defined position relative to an ultrasound probe. The guidance device provides additional support of a needle tip near the needle injection site to maintain a selected path throughout an injection. The additional support is automatically retracted for simple disposal with the used syringe after an injection. The guidance device minimizes contact of soiled components and enables syringe insertion, alignment, and removal for multiple different injections without removal of an ultrasound probe from the patient.

Abstract: An enclosure or housing for an air monitoring instrument package for mounting on the roof or other surface on the outside of vehicles such as cars, trucks, buses, trams, trains and ships. By measuring air pollutants from moving vehicles, it is possible to explore the distribution of air pollutants throughout a city or rural area for the identification of sources of different pollutants, estimating human exposures to air pollutants, and mapping air pollutants with high resolution. The disclosed device provides continuous sampling of outside air while simultaneously protecting the delicate instruments from weather elements such as high wind, rain, snow, sleet and hail. The design also allows a nearly constant flow rate of sampled air independent of vehicle velocity. An optional impaction region further reduces transmission of mist and large particles to the chamber containing the measurement package.

Abstract: The disclosure provides salts of (2R,6R)-hydroxynorketamine (HNK), wherein the salt is with an organic acid chosen from malonic acid, salicylic acid, ethane sulfonic acid, glycolic acid, stearic acid, or capric acid, and their crystal forms.