Abstract: An electrosurgical system includes an electrosurgical instrument having an electrode with a polymeric dielectric coating; and an electrosurgical generator, which includes a power converter configured to generate RF energy; a sensor coupled to the power converter and configured to sense a parameter of the RF energy; and a controller coupled to the sensor and the power converter. The controller is configured to control the power converter to output an RF waveform to achieve conductor breakthrough through the polymeric dielectric coating. The controller is further configured to determine whether the conductor breakthrough occurred based on the parameter; and execute a treatment algorithm based on a determination of the conductor breakthrough.

Abstract: An enhanced haptic feedback system for medical diagnostics includes a laparoscope configured to be inserted into a body cavity to view tissue and obtain an image of the viewed tissue. An imaging device is configured to acquire physiological data about tissue, process the acquired physiological data, and output the processed data to a graphical user haptic interface (GUHI) capable of generating tangible sensations utilizing one or more haptic interfaces. The GUHI is configured to combine the image received from the laparoscope and the processed physiological data received from the imaging device to provide tangible sensations on both a front screen of the GUHI and a rear screen of the GUHI allowing a surgeon the sensation of feeling for abnormal tissue conditions between the surgeon's hands.

Abstract: A surgical instrument includes a housing, a shaft extending distally from the housing, an end effector disposed at a distal end of the shaft, an actuator operably coupled to the housing, an actuation assembly, and a sensor module. The actuation assembly extends through the housing and the shaft and includes a distal end operably coupled to the end effector or a component associated therewith, a proximal end operably coupled to the actuator, and a spring. Actuation of the actuator manipulates the end effector or deploys the component relative thereto. The sensor module is disposed within the housing and configured to sense a property of the spring indicative of an amount the spring has been compressed. The sensor module is further configured, based upon the sensed property, to determine a condition of the end effector or the relative position of the component.

Abstract: The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with catalytic activity tethered to a ligand that is coordinated to the active metal center of the complex.

Abstract: An apparatus includes an inner rotor motor and a stationary wiring conduit. The inner rotor motor includes a stator and a rotor spaced at least in part radially inside the stator. The rotor is rotatable relative to the stator about an axis. The rotor includes a rotatable shaft that presents a shaft bore extending axially therethrough. The stationary wiring conduit extends through the shaft bore and is fixed relative to the motor housing. The shaft bore rotatably receives the wiring conduit, such that the wiring conduit is permitted to remain stationary as the shaft rotates.

Abstract: The disclosure pertains to amphiphilic block copolymers comprising an aliphatic polycarbonate chain coupled to a hydrophilic polymer. Such amphiphilic polymers may have the formula A-L-B, where A- is a polycarbonate or polyethercarbonate chain having from about 3 to about 500 repeating units, L is a linker moiety and -B is a hydrophilic oligomer having from about 4 to about 200 repeating units. Provided copolymers are useful as surfactants capable of emulsifying aqueous solutions and supercritical carbon dioxide. Provided copolymers also have utility as additives for use in enhanced oil recovery methods.

Abstract: Provided herein are bicontinuous nanosphere nanocarrier that allow for slow, sustained release or allow for targeted release of target molecules. Further embodiments of the present invention provide bicontinuous nanosphere nanocarrier comprising a photosensitizer and a suitable polymer. Also provided are methods for making and using the photosensitive nanocarrier.

Abstract: A method for treating tissue includes determining whether tissue is present between first and second jaw members. In a case where it is determined that tissue is present between the first and second jaw members, the method further includes determining whether activation has been initiated. In a case where it is determined that activation has been initiated, the method further includes supplying electrosurgical energy to the first and second jaw members to seal the tissue and, if it is determined that sealing is complete: stopping the supply of electrosurgical energy; activating a thermal cutting element to supply thermal energy to cut the sealed present tissue; determining if thermal cutting is complete; and, in a case where it is determined that the thermal cutting is complete, stopping and the supply of thermal energy.

Abstract: A graphical user interface accessible to a user and suitable for receiving a user-supplied movement direction or selection input through a directional controller to manage focus, including: a plurality of objects configured in a hierarchical structure; a first focus transfer element configured to transfer the focus from the currently focused object when the user supplied movement direction is received from the directional controller; and a second focus transfer element configured to transfer the focus from the currently focused object when the selection input is received from the directional controller.

Abstract: Methods, system, and kits are provided for sample identification, and, more specifically, for designing, and/or making, and/or using sample discriminating codes or barcodes for identifying sample nucleic acids or other biomolecules or polymers. For example, a plurality of flowspace codewords may be generated, the codewords comprising a string of characters. A location for at least one padding character within the flowspace codewords may be determined. The padding character may be inserted into the flowspace codewords at the determined location. After the inserting, a plurality of the flowspace codewords may be selected based on satisfying a predetermined minimum distance criteria, wherein the selected codewords correspond to valid base space sequences according to a predetermined flow order. And the barcode sequences corresponding to the selected codewords may be manufactured.

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

Abstract: The present invention encompasses polyurethane compositions comprising aliphatic polycarbonate chains. In one aspect, the present invention encompasses polyurethane foams, thermoplastics and elastomers derived from aliphatic polycarbonate polyols and polyisocyanates wherein the polyol chains contain a primary repeating unit having a structure: In another aspect, the invention provides articles comprising the inventive foam and elastomer compositions as well as methods of making such compositions.

Abstract: An enhanced haptic feedback system for medical diagnostics includes a laparoscope configured to be inserted into a body cavity to view tissue and obtain an image of the viewed tissue. An imaging device is configured to acquire physiological data about tissue, process the acquired physiological data, and output the processed data to a graphical user haptic interface (GUHI) capable of generating tangible sensations utilizing one or more haptic interfaces. The GUHI is configured to combine the image received from the laparoscope and the processed physiological data received from the imaging device to provide tangible sensations on both a front screen of the GUHI and a rear screen of the GUHI allowing a surgeon the sensation of feeling for abnormal tissue conditions between the surgeon's hands.

Abstract: A surgical instrument includes a housing, a shaft extending distally from the housing, an end effector assembly disposed at a distal end of the shaft, a knife slidably disposed within the shaft, a movable handle operably coupled to the housing, a trigger operably coupled to the housing, a drive assembly operably coupled between the movable handle and the end effector assembly such that movement of the movable handle manipulates the end effector assembly, and a linkage operably coupled between the trigger and the knife such that movement of the trigger deploys the knife. In an initial position of the movable handle, a portion of a drive housing of the drive assembly intersects a path of movement of the linkage to inhibit movement of the linkage, thereby inhibiting actuation of the trigger.

Abstract: Oligonucleotide primers and methods of use in producing sequencing libraries are provided according to aspects of the present disclosure which include, from 5? to 3?, a homopolymer-hybridizing region, and an anchor region comprising 5?-(?)nNm-3?, wherein the homopolymer-hybridizing region is a contiguous sequence of 5 to 20 elements, wherein the elements are nucleotides or Tm increasing nucleotide analogs, wherein at least 4 of the elements are Tm increasing nucleotide analogs, wherein the homopolymer-hybridizing region hybridizes to a complementary homopolymer tract of a target nucleic acid, wherein the complementary homopolymer tract comprises a contiguous sequence of complementary elements, wherein ? is any nucleotide or nucleotide analog with the proviso that ? is not a nucleotide or nucleotide analog complementary to a complementary element of the complementary homopolymer tract, and wherein N is any nucleotide or nucleotide analog.

Abstract: A surgical instrument includes a housing, a shaft extending distally from the housing, an end effector disposed at a distal end of the shaft, an actuator operably coupled to the housing, an actuation assembly, and a sensor module. The actuation assembly extends through the housing and the shaft and includes a distal end operably coupled to the end effector or a component associated therewith, a proximal end operably coupled to the actuator, and a spring. Actuation of the actuator manipulates the end effector or deploys the component relative thereto. The sensor module is disposed within the housing and configured to sense a property of the spring indicative of an amount the spring has been compressed. The sensor module is further configured, based upon the sensed property, to determine a condition of the end effector or the relative position of the component.

Abstract: A forceps includes a shaft defining first opposed distal recesses, a drive bar slidably disposed within the shaft and defining second opposed distal recesses, and an end effector assembly including first and second jaw members. Each jaw member defines a proximal flange and a distal jaw body. The proximal flanges each define an aperture and a cam slot. A pivot pin extends through the apertures with ends of the pivot pin extending outwardly from the jaw members to be at least partially disposed within the first recesses and fixedly engaged therewith. A drive pin extends through the cam slots with ends of the drive pin extending outwardly from the jaw members to be at least partially disposed within the second recesses and fixedly engaged therewith such that translation of the drive bar relative to the end effector assembly pivots the jaw members between spaced-apart and approximated positions.

Abstract: A colpotomy system includes a colpotomy cup that extends to a distal surface and defines a longitudinal axis. The colpotomy system further includes a cutter operably coupled to the colpotomy cup and configured to travel along an arcuate path defined about the distal surface of the colpotomy cup. The cutter actuatable to separate a uterus from a vagina as the cutter rotates about the longitudinal axis of the colpotomy cup.

Abstract: The present invention encompasses polymer compositions comprising aliphatic polycarbonate chains containing functional groups that increase the polymer's ability to wet or adhere to inorganic materials. In certain embodiments, chain ends of the aliphatic polycarbonates are modified to introduce silicon-containing functional groups, boron-containing functional groups, phosphorous-containing functional groups, sulfonic acid groups or carboxylic acid groups.

Abstract: A system and method for automatically generating a narrative story receives data and information pertaining to a domain event. The received data and information and/or one or more derived features are then used to identify a plurality of angles for the narrative story. The plurality of angles is then filtered, for example through use of parameters that specify a focus for the narrative story, length of the narrative story, etc. Points associated with the filtered plurality of angles are then assembled and the narrative story is rendered using the filtered plurality of angles and the assembled points.