Abstract: A colpotomy system includes an energy source and a uterine manipulator that is electrically coupled to the energy source. The uterine manipulator supports a colpotomy cup and extends to a conductive distal tip portion. The colpotomy cup includes a conductive surface. One or both of the conductive distal tip portion and the conductive surface of the colpotomy cup are configured to return monopolar energy to the energy source.

Abstract: A surgical instrument is provided and includes a housing having a shaft. An end effector assembly is operatively connected to a distal end of the shaft and has a pair of first and second jaw members that are movable relative to one another. A drive assembly operably couples to a handle assembly associated with the housing and is configured to impart movement of a respective jaw member when the handle assembly is actuated. A spring component operably associated with each of the jaw members is configured to provide a sealing force at the jaw members.

Abstract: An end effector assembly for a surgical instrument includes first and second jaw members each including a jaw housing, an electrically-conductive tissue-treatment plate, and a longitudinally-extending channel. The first and/or second jaw member is movable relative to the other between a spaced-apart position and an approximated position. A cutting mechanism is disposed at least partially within the second jaw member. The cutting mechanism may include an inflatable bladder, a fluid line coupled to the inflatable bladder, and a knife coupled to the inflatable bladder. The cutting mechanism may alternatively include a fluid line, a knife, and a sealing member that defines a variable-volume sealed chamber within the longitudinally-extending channel of the second jaw member. The cutting mechanism may alternatively include at least one electromagnet, at least one electrical wire coupled to the at least one electromagnet, and a knife operably coupled to the at least one electromagnet.

Abstract: A surgical instrument includes a housing that supports an elongated shaft. A selectively movable drive rod extends through the elongated shaft and carries a cam pin in a longitudinal direction. An end effector for surgically treating tissue is supported by the elongated shaft and includes upper and lower jaw members pivotally coupled to one another about a pivot axis. The upper jaw member includes a first pair of laterally spaced flanges, and the lower jaw member includes a second pair of laterally spaced flanges defining a camming slot for engaging the cam pin. The flanges are arranged in an offset configuration where one flange of the upper jaw member is positioned on a laterally exterior side of a corresponding flange of the lower jaw member, and the other flange of the upper jaw member is positioned on a laterally interior side of the other flange of the lower jaw member.

Abstract: In one aspect, the present invention encompasses blends of polyols comprising a polycarbonate polyol and an additional polyol selected from a polyether or polyester polyol, resulting polyurethanes derived from such blends of polyols, methods of making such polyurethane compositions, and coatings and adhesives derived from such polyurethane compositions.

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

Abstract: Jaw members of end effector assemblies include sealing plates configured to direct the amount and flow of energy through the sealing plates. The sealing plates may have a height varying from a minimal height to a maximum height along a width or a length of the sealing plate and/or a sealing surface including at least two impedance zones having different impedance values.

Abstract: Jaw members of end effector assemblies include sealing plates configured to direct the amount and flow of energy through the sealing plates. The sealing plates may have a height varying from a minimal height to a maximum height along a width or a length of the sealing plate and/or a sealing surface including at least two impedance zones having different impedance values.

Abstract: An electrosurgical system includes an electrosurgical instrument having an electrode with a polymeric dielectric coating; and an electrosurgical generator, which includes a power converter configured to generate RF energy; a sensor coupled to the power converter and configured to sense a parameter of the RF energy; and a controller coupled to the sensor and the power converter. The controller is configured to control the power converter to output an RF waveform to achieve conductor breakthrough through the polymeric dielectric coating. The controller is further configured to determine whether the conductor breakthrough occurred based on the parameter; and execute a treatment algorithm based on a determination of the conductor breakthrough.

Abstract: An enhanced haptic feedback system for medical diagnostics includes a laparoscope configured to be inserted into a body cavity to view tissue and obtain an image of the viewed tissue. An imaging device is configured to acquire physiological data about tissue, process the acquired physiological data, and output the processed data to a graphical user haptic interface (GUHI) capable of generating tangible sensations utilizing one or more haptic interfaces. The GUHI is configured to combine the image received from the laparoscope and the processed physiological data received from the imaging device to provide tangible sensations on both a front screen of the GUHI and a rear screen of the GUHI allowing a surgeon the sensation of feeling for abnormal tissue conditions between the surgeon's hands.

Abstract: A surgical instrument includes a housing, a shaft extending distally from the housing, an end effector disposed at a distal end of the shaft, an actuator operably coupled to the housing, an actuation assembly, and a sensor module. The actuation assembly extends through the housing and the shaft and includes a distal end operably coupled to the end effector or a component associated therewith, a proximal end operably coupled to the actuator, and a spring. Actuation of the actuator manipulates the end effector or deploys the component relative thereto. The sensor module is disposed within the housing and configured to sense a property of the spring indicative of an amount the spring has been compressed. The sensor module is further configured, based upon the sensed property, to determine a condition of the end effector or the relative position of the component.

Abstract: The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with catalytic activity tethered to a ligand that is coordinated to the active metal center of the complex.

Abstract: An apparatus includes an inner rotor motor and a stationary wiring conduit. The inner rotor motor includes a stator and a rotor spaced at least in part radially inside the stator. The rotor is rotatable relative to the stator about an axis. The rotor includes a rotatable shaft that presents a shaft bore extending axially therethrough. The stationary wiring conduit extends through the shaft bore and is fixed relative to the motor housing. The shaft bore rotatably receives the wiring conduit, such that the wiring conduit is permitted to remain stationary as the shaft rotates.

Abstract: The disclosure pertains to amphiphilic block copolymers comprising an aliphatic polycarbonate chain coupled to a hydrophilic polymer. Such amphiphilic polymers may have the formula A-L-B, where A- is a polycarbonate or polyethercarbonate chain having from about 3 to about 500 repeating units, L is a linker moiety and -B is a hydrophilic oligomer having from about 4 to about 200 repeating units. Provided copolymers are useful as surfactants capable of emulsifying aqueous solutions and supercritical carbon dioxide. Provided copolymers also have utility as additives for use in enhanced oil recovery methods.

Abstract: A method for treating tissue includes determining whether tissue is present between first and second jaw members. In a case where it is determined that tissue is present between the first and second jaw members, the method further includes determining whether activation has been initiated. In a case where it is determined that activation has been initiated, the method further includes supplying electrosurgical energy to the first and second jaw members to seal the tissue and, if it is determined that sealing is complete: stopping the supply of electrosurgical energy; activating a thermal cutting element to supply thermal energy to cut the sealed present tissue; determining if thermal cutting is complete; and, in a case where it is determined that the thermal cutting is complete, stopping and the supply of thermal energy.

Abstract: A graphical user interface accessible to a user and suitable for receiving a user-supplied movement direction or selection input through a directional controller to manage focus, including: a plurality of objects configured in a hierarchical structure; a first focus transfer element configured to transfer the focus from the currently focused object when the user supplied movement direction is received from the directional controller; and a second focus transfer element configured to transfer the focus from the currently focused object when the selection input is received from the directional controller.

Abstract: Provided herein are bicontinuous nanosphere nanocarrier that allow for slow, sustained release or allow for targeted release of target molecules. Further embodiments of the present invention provide bicontinuous nanosphere nanocarrier comprising a photosensitizer and a suitable polymer. Also provided are methods for making and using the photosensitive nanocarrier.

Abstract: Methods, system, and kits are provided for sample identification, and, more specifically, for designing, and/or making, and/or using sample discriminating codes or barcodes for identifying sample nucleic acids or other biomolecules or polymers. For example, a plurality of flowspace codewords may be generated, the codewords comprising a string of characters. A location for at least one padding character within the flowspace codewords may be determined. The padding character may be inserted into the flowspace codewords at the determined location. After the inserting, a plurality of the flowspace codewords may be selected based on satisfying a predetermined minimum distance criteria, wherein the selected codewords correspond to valid base space sequences according to a predetermined flow order. And the barcode sequences corresponding to the selected codewords may be manufactured.

Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

Abstract: The present invention encompasses polyurethane compositions comprising aliphatic polycarbonate chains. In one aspect, the present invention encompasses polyurethane foams, thermoplastics and elastomers derived from aliphatic polycarbonate polyols and polyisocyanates wherein the polyol chains contain a primary repeating unit having a structure: In another aspect, the invention provides articles comprising the inventive foam and elastomer compositions as well as methods of making such compositions.