Abstract: The disclosure provides oligonucleotide-ligand conjugates to facilitate the systemic delivery of oligonucleotides designed to prevent, limit or modulate the expression of mRNA molecules. The conjugates comprise nucleotides which are linked to lipid conjugate moieties or adamantyl groups.

Abstract: Oligonucleotides and compositions including the same are disclosed for inhibiting or reducing apolipoprotein C-III (APOC3) gene expression. Methods of making and using the oligonucleotides also are disclosed, particularly uses relating to treating diseases, disorders and/or conditions associated with APOC3 expression.

Abstract: A bridge connector system includes a housing having one or more chambers, one or more connectors held in the corresponding chambers, one or more bridge connectors received in the corresponding chambers and electrically connected to the corresponding connectors, and one or more harness connectors coupled to the housing and being electrically connected to the corresponding bridge connectors. The bridge connectors electrically connect the harness connectors with the connectors.

Abstract: A connector includes a housing having a contact receiving passageway extending through a mating end of the housing in a longitudinal direction and a contact disposed in the contact receiving passageway. The housing has a window extending through a wall of the housing in a direction perpendicular to the longitudinal direction. The contact has a mating section disposed at the mating end and a contact section extending from the mating section. An exposed portion of the contact section is exposed to an area exterior of the housing through the window.

Abstract: A school bus stop arm and drive unit therefor are disclosed. The stop arm includes a stop sign and a drive unit for moving the stop sign between a retracted position and a deployed position. In some embodiments the stop sign is illuminated. In some embodiments the drive unit includes a controller.

Abstract: Techniques are directed to controlling access to resources on a message bus of a network communication device. The techniques may include, by the network communication device, processing a message bus access policy file uniquely corresponding to a process. The message bus access policy file may include a certificate securely associating the message bus access policy file with the process. The techniques may further include, by the network communication device, based at least in part on the processing the message bus access policy file, exposing one or more resources of the network communication device to the process on the message bus, in a manner corresponding to at least one resource access permission indication contained within the message bus access policy file.

Abstract: The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a single stranded extension (in most embodiments, the single stranded extension comprises at least one modified nucleotide and/or phosphate back bone modification). Such single stranded extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be effective RNA inhibitory agents compared to corresponding double stranded DsiRNAs.

Abstract: This disclosure relates to compounds, compositions, and methods useful for reducing ?-1 antitrypsin target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.

Abstract: A reconfigurable electrical box includes an enclosure, and an electrical component arranged within the enclosure. A plurality of base contacts are arranged within the enclosure and are electrically connected to the electrical component, and a plurality of external contacts are arranged over and selectively conductively connected to a portion of the plurality of base contacts. A frame is fitted over the plurality of external contacts and is attached to the enclosure. The frame fixes the position of the external contacts relative to the plurality of base contacts.

Abstract: The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a single stranded extension (in most embodiments, the single stranded extension comprises at least one modified nucleotide and/or phosphate back bone modification). Such single stranded extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be effective RNA inhibitory agents compared to corresponding double stranded DsiRNAs.

Abstract: Techniques are directed to controlling access to resources on a message bus of a network communication device. The techniques may include, by the network communication device, processing a message bus access policy file uniquely corresponding to a process. The message bus access policy file may include a certificate securely associating the message bus access policy file with the process. The techniques may further include, by the network communication device, based at least in part on the processing the message bus access policy file, exposing one or more resources of the network communication device to the process on the message bus, in a manner corresponding to at least one resource access permission indication contained within the message bus access policy file.

Abstract: A school bus stop arm and drive unit therefor are disclosed. The stop an includes a stop sign and a drive unit for moving the stop sign between a retracted position and a deployed position. The drive unit comprises a motor operably coupled to the stop sign, one or more position sensors operable to detect the presence of the stop sign, and a controller for controlling operation of the motor. The controller configured to, monitor one or more operating characteristics of the motor for conditions indicative of an obstruction to movement of the stop sign, monitor the position sensor for a confirmation signal indicative of the presence of the stop sign in the deployed or retracted position, and based on the conditions indicative of an obstruction and the confirmation signal, determine if the stop sign has reached one of the deployed and retracted positions or is being obstructed.

Abstract: This invention relates to compounds, compositions, and methods useful for reducing ?-1 antitrypsin target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.

Abstract: Oligonucleotides and compositions including the same are disclosed for inhibiting or reducing patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene expression. Methods of making and using the oligonucleotides also are disclosed, particularly uses relating to treating diseases, disorders and/or conditions associated with PNPLA3 expression.

Abstract: Oligonucleotides are provided herein that inhibit KHK expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with KHK expression.

Abstract: Examples are disclosed that relate to securing a display screen of a display device to a body of the display device. One example provides a display device including a body, a display screen, and a connecting structure comprising a tab component having one or more tabs, the tab component being coupled to one of the display screen and the body, a hook component including one or more hooks complementary to the one or more tabs, the hook component coupled to the other of the display screen and the body, the tab component and the hook component being moveable relative to one another to selectively engage the one or more tabs with the one or more hooks, and an actuation mechanism accessible from an exterior side of the body, the actuation mechanism being actuatable to engage the tab component and the hook component.

Abstract: An electrical connector comprises a housing defining a receptacle opening for receiving a mating connector in a mating direction and a terminal positioning component slidably received within the receptacle opening and moveable in the mating direction. The terminal positioning component includes a pin protection plate defining at least one aperture sized to receive a conductive pin of at least one terminal arranged within the housing, and a terminal assurance element extending from the pin protection plate in the mating direction. The terminal assurance element is adapted to prevent the movement of the component in the mating direction when the at least one terminal is in a partially inserted state within the housing. The connector further comprises a first locking element arranged on a wall of the housing for selectively fixing the position of the terminal positioning component within the receptacle in the mating direction.

Abstract: Techniques are directed to controlling access to resources on a message bus of a network communication device. The techniques may include, by the network communication device, processing a message bus access policy file uniquely corresponding to a process. The message bus access policy file may include a certificate securely associating the message bus access policy file with the process. The techniques may further include, by the network communication device, based at least in part on the processing the message bus access policy file, exposing one or more resources of the network communication device to the process on the message bus, in a manner corresponding to at least one resource access permission indication contained within the message bus access policy file.

Abstract: The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a single stranded extension (in most embodiments, the single stranded extension comprises at least one modified nucleotide and/or phosphate back bone modification). Such single stranded extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be effective RNA inhibitory agents compared to corresponding double stranded DsiRNAs.