Abstract: Techniques for transmitting messages to send configuration information, and/or commands, to features, agents, applications and/or other aspects of endpoints and/or networked computing devices. In an example, server, a host of an analytics platform, or other computing device may send messages within a network to an endpoint that is remote from the computing device. In the example, a first message may be sent to a first agent operating on the endpoint, wherein the first message directs configuration of a first feature of the first agent. The computing device may receive consumption data from the endpoint, which may be monitored and/or analyzed by the analytics platform of the computing device. In the example, a second message may be sent to a second agent operating on the endpoint, wherein the second message has a parameter that allows free-format data, and wherein a command is encoded within the parameter.

Abstract: Provided herein are double-stranded nucleic acid inhibitor molecules having a sense strand with a stem loop structure and an antisense strand, where the stem portion of the stem loop structure contains one or more Tm-increasing nucleotides. Also provided are methods and compositions for reducing target gene expression and methods and compositions for treating a disease of interest.

Abstract: Apparatus and methods are provided to minimize waste and improve quality and production in web processing operations. The apparatus and methods provide defect detection in deposition of acquisition material, which on current machines frequently flips and is difficult to detect when it has flipped causing manufacturers to scrap thousands of products. Using the present invention, defects are able to be detected by discerning a difference in the appearance from side to side with a vision camera, and an acquisition inverter can flip the material to a correct orientation.

Abstract: A system and method for automatically flushing urine from a pet litter box are disclosed. In one embodiment, the system and method may be directed to a combination of a urine-separating pet litter box with odor controlling conditionally non-absorbent litter and an automatic flushing device. The urine-separating pet litter box includes an upper litter tray with a perforated bottom and a lower liquid holding tank, which holds water inside. The lower liquid holding tank is connected to water intake pipes and a drainpipe and flushes the urine and holding water and fills freshwater in the lower liquid holding tank by detecting a water level of the holding water in the lower liquid holding tank with sensors. The flushing was performed by using a Venturi pump effect to control two electrical valves open or close. In some embodiment, Sodium Sesquicarbonate (SSC) may be used as conditionally non-absorbent litter for complete disposal of feces.

Abstract: Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for preparing a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for therapeutic delivery of an anionic agent to a patient in need thereof, where the anionic agent is formulated in a lipid-containing particle as described herein.

Abstract: The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

Abstract: A system and method for automatically flushing urine from a pet litter box are disclosed. In one embodiment, the system and method may be directed to a combination of a urine-separating pet litter box with odor controlling conditionally non-absorbent litter and an automatic flushing device. The urine-separating pet litter box includes an upper litter tray with a perforated bottom and a lower liquid holding tank, which holds water inside. The lower liquid holding tank is connected to water intake pipes and a drainpipe and flushes the urine and holding water and fills freshwater in the lower liquid holding tank by detecting a water level of the holding water in the lower liquid holding tank with sensors. The flushing was performed by using a Venturi pump effect to control two electrical valves open or close. In some embodiment, Sodium Sesquicarbonate (SSC) may be used as conditionally non-absorbent litter for complete disposal of feces.

Abstract: A system and method for automatically flushing urine from a pet litter box are disclosed. In one embodiment, the system and method may be directed to a combination of a urine-separating pet litter box with odor controlling conditionally non-absorbent litter and an automatic flushing device. The urine-separating pet litter box includes an upper litter tray with a perforated bottom and a lower liquid holding tank, which holds water inside. The lower liquid holding tank is connected to water intake pipes and a drainpipe and flushes the urine and holding water and fills freshwater in the lower liquid holding tank by detecting a water level of the holding water in the lower liquid holding tank with sensors. The flushing was performed by using a Venturi pump effect to control two electrical valves open or close. In some embodiment, Sodium Sesquicarbonate (SSC) may be used as conditionally non-absorbent litter for complete disposal of feces.

Abstract: The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

Abstract: Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for preparing a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for therapeutic delivery of an anionic agent to a patient in need thereof, where the anionic agent is formulated in a lipid-containing particle as described herein.

Abstract: The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a pattern of deoxyribonucleotides (in most embodiments, the pattern comprises at least one deoxyribonucleotide-deoxyribonucleotide base pair) designed to direct the site of Dicer enzyme cleavage within the dsNA molecule. Deoxyribonucleotides of the dsNA molecules of the invention are located within a region of the dsNA that can be excised via Dicer cleavage to generate an active siRNA agent that no longer contains the deoxyribonucleotide pattern (e.g., deoxyribonucleotide-deoxyribonucleotide base pairs). Such DNA-extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be more effective RNA inhibitory agents than corresponding double stranded RNA-extended DsiRNAs.

Abstract: A chest, which can comprise a refrigerated chest such as a freezer for example, includes an opening at the top of the chest through which access can be had to a chest interior. The opening is arranged substantially horizontally when the chest is maintained in its normal operational state. One or more doors mounted to the chest at the opening at the top of the chest are selectively movable between a position closing off the entire opening at the top of the chest and a position opening up the opening, including a horizontal position, thereby providing access to the refrigerated chest interior through the opening. The one or more doors can comprise two equal-sized doors. A respective door support can be provided outside the chest interior for each of the one or more doors at which a door of the one or more doors is supported in a horizontal position.

Abstract: The present invention is based, at least in part, upon discovery of a process for identifying phase changing peptides. Such phase changing peptides are capable of enhancing in vitro and in vivo delivery of oligonucleotides (e.g., dsRNAs) in lipidic, vesicular, micellar and/or naked oligonucleotide formulations.

Abstract: The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

Abstract: A signal detection system for use with a signaling system is disclosed, the signal detection system comprising a plurality of electrical terminals including a source terminal and an output terminal, the output terminal being connected to a signaling device. An auxiliary terminal electrically coupled to at least one of the plurality of electrical terminals is provided. A current sensor is coupled to the auxiliary terminal for detecting an electrical signal for controlling the signaling device. The current sensor generating an output signal in response to the detection of the electrical signal for controlling the signaling device for monitoring the status of the signaling device. Also disclosed is a method for installing a signal detection system in a wayside signaling system including a signaling device for monitoring a status of the signaling device. An apparatus for connecting a current sensor to a signaling device is also disclosed.

Abstract: A flushable cat litter present in a litter box designed to allow a majority of the cat urine to drain into a compartment or container separate from the portion of the litter box holding cat feces and the cat litter. The cat litter preferably includes a mixture of sodium bicarbonate and sodium carbonate.

Abstract: The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

Abstract: A chest, which can comprise a refrigerated chest such as a freezer for example, includes an opening at the top of the chest through which access can be had to a chest interior. The opening is arranged substantially horizontally when the chest is maintained in its normal operational state. One or more doors mounted to the chest at the opening at the top of the chest are selectively movable between a position closing off the entire opening at the top of the chest and a position opening up the opening, including a horizontal position, thereby providing access to the refrigerated chest interior through the opening. The one or more doors can comprise two equal-sized doors. A respective door support can be provided outside the chest interior for each of the one or more doors at which a door of the one or more doors is supported in a horizontal position.

Abstract: The present disclosure relates to a monitor for a blowout preventer of a wellbore. The blowout preventer includes a housing, rams, and an actuator comprising a cylinder with a piston. The piston is operatively connectable with the ram and movable therewith. The monitor includes a monitor base operatively connectable to the cylinder (the monitor base having an interior side inside the cylinder and an exterior side outside the cylinder), an interior plate positionable inside the cylinder about the interior side of the base (the interior plate operatively connectable to the piston and movable therewith), an exterior plate positionable outside the cylinder about the exterior surface of the monitor base (the exterior plate coupled by magnets to the interior plate and rotatable therewith), and a trigger sensor operatively connectable about the monitor base and the exterior plate to detect rotation thereof whereby a position of the ram may be determined.

Abstract: The present invention is based, at least in part, upon discovery of a process for identifying phase changing peptides. Such phase changing peptides are capable of enhancing in vitro and in vivo delivery of oligonucleotides (e.g., dsRNAs) in lipidic, vesicular, micellar and/or naked oligonucleotide formulations.