Abstract: A combustor dome assembly includes a dome plate with upstream and downstream faces and an aperture therein; a deflector with body and a tube section, the deflector fixedly attached to the dome plate adjacent the downstream face with the tube section in the aperture; a retainer having an annular body with a central opening therein, an annular flange, and at least one hook defining a slot, the retainer being fixedly attached to the dome plate adjacent the upstream face of the dome plate with the flange received in the aperture; and an annular mixer with a radial array of swirl vanes and an annular mounting flange, with a retention tab extending radially outward from the mounting flange. The mixer is disposed adjacent the upstream face with the mounting flange against the retainer. The retention tab is engaged in the slot to prevent axial withdrawal of the mixer from the retainer.

Abstract: A signal detection system for use with a signaling system is disclosed, the signal detection system comprising a plurality of electrical terminals including a source terminal and an output terminal, the output terminal being connected to a signaling device. An auxiliary terminal electrically coupled to at least one of the plurality of electrical terminals is provided. A current sensor is coupled to the auxiliary terminal for detecting an electrical signal for controlling the signaling device. The current sensor generating an output signal in response to the detection of the electrical signal for controlling the signaling device for monitoring the status of the signaling device. Also disclosed is a method for installing a signal detection system in a wayside signaling system including a signaling device for monitoring a status of the signaling device. An apparatus for connecting a current sensor to a signaling device is also disclosed.

Abstract: A consist communication system is disclosed for use with a train consist. The consist communication system may have a fluid conduit, at least a first cable disposed within the fluid conduit and configured to transmit communication signals, and at least a second cable disposed within the fluid conduit and configured to transmit electrical power. The communication conduit may also have a coupling fixedly connected to an end of the fluid conduit, a first transformer coil connected to the at least a first cable, and a second transformer coil connected to the at least a second cable and disposed in an orthogonal orientation relative to the first transformer coil.

Abstract: A communication system is disclosed for use with a train consist. The consist communication system may have a first fluid conduit, a first coupling connected to the first fluid conduit, a first cover connected to the first coupling and configured to close an end of the first fluid conduit, and at least a first cable disposed within the first fluid conduit. The system may also have a second fluid conduit substantially identical to the first fluid conduit, a second coupling substantially identical to the first coupling, fixedly connected to the second fluid conduit, and connectable to the first coupling, and a second cover connected to the second coupling and configured to close an end of the second fluid conduit. At least a second cable may be disposed within the second fluid conduit in communication with the at least a first cable through the first and second covers. The first and second fluid conduits may be pressurized.

Abstract: A consist communication system is disclosed for use with a train consist. The consist communication system may have a fluid conduit, at least a first cable disposed within the fluid conduit and configured to transmit communication signals, and at least a second cable disposed within the fluid conduit and configured to transmit electrical power. The communication conduit may also have a coupling fixedly connected to an end of the fluid conduit, a first transformer coil connected to the at least a first cable, and a second transformer coil connected to the at least a second cable and disposed in an orthogonal orientation relative to the first transformer coil.

Abstract: A coupling for a communication conduit is disclosed for use with a train consist. The coupling may include a nipple configured for insertion within a fluid conduit, a flange configured to engage an end of the fluid conduit, a retention member configured to engage an outer surface of the fluid conduit, a first fitting extending from the flange away from the nipple, and, a retaining tab configured to retain a second fitting of another coupling in engagement with the first fitting. The coupling may further include a closure mechanism configured to close off an end of the first fitting and movable during engagement with the second fitting to open the end of the first fitting.

Abstract: A consist communication system is disclosed for use with a train consist. The system may have a sensor associated with a component of the consist and configured to generate a signal indicative of a performance parameter of the component. The system may further include a controller, a fluid conduit, at least a first cable disposed within the fluid conduit and configured to transmit the signal from the sensor to the controller, and a glad-hand coupling fixedly connected to an end of the fluid conduit.

Abstract: This invention relates to compounds, compositions, and methods useful for reducing HIF-1? target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents.

Abstract: The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a pattern of deoxyribonucleotides (in most embodiments, the pattern comprises at least one deoxyribonucleotide-deoxyribonucleotide base pair) designed to direct the site of Dicer enzyme cleavage within the dsNA molecule. Deoxyribonucleotides of the dsNA molecules of the invention are located within a region of the dsNA that can be excised via Dicer cleavage to generate an active siRNA agent that no longer contains the deoxyribonucleotide pattern (e.g., deoxyribonucleotide-deoxyribonucleotide base pairs). Such DNA-extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be more effective RNA inhibitory agents than corresponding double stranded RNA-extended DsiRNAs.

Abstract: A partial cover and tailgate seal is added to the bed of a truck or trailer to prevent a slurry-type load from overflowing the tailgate of the bed when traversing steep terrain and to help seal the interface between the tailgate and the bed.

Abstract: A method of assembling a combustion system for a gas turbine engine includes providing a combustion chamber frame, an inner casing structure, and an outer casing structure. The method also includes mounting the combustion chamber frame between the inner casing structure and the outer casing structure such that the combustion chamber frame is coupled to the inner casing structure and the outer casing structure.

Abstract: Apparatus and methods are provided to minimize waste and improve quality and production in web processing operations. The apparatus and methods provide defect detection in deposition of acquisition material, which on current machines frequently flips and is difficult to detect when it has flipped causing manufacturers to scrap thousands of products. Using the present invention, defects are able to be detected by discerning a difference in the appearance from side to side with a vision camera, and an acquisition inverter can flip the material to a correct orientation.

Abstract: The invention features compositions and methods that are useful for reducing the expression or activity of a specified gene in eukaryotic cell.

Abstract: The invention provides compositions and methods for reducing expression of a target gene in a cell, involving contacting a cell with an isolated double stranded nucleic acid (dsNA) in an amount effective to reduce expression of a target gene in a cell. The dsNAs of the invention possess a single stranded extension (in most embodiments, the single stranded extension comprises at least one modified nucleotide and/or phosphate back bone modification). Such single stranded extended Dicer-substrate siRNAs (DsiRNAs) were demonstrated to be effective RNA inhibitory agents compared to corresponding double stranded DsiRNAs.

Abstract: A combustor dome assembly includes a dome plate with upstream and downstream faces and an aperture therein; a deflector with body and a tube section, the deflector fixedly attached to the dome plate adjacent the downstream face with the tube section in the aperture; a retainer having an annular body with a central opening therein, an annular flange, and at least one hook defining a slot, the retainer being fixedly attached to the dome plate adjacent the upstream face of the dome plate with the flange received in the aperture; and an annular mixer with a radial array of swirl vanes and an annular mounting flange, with a retention tab extending radially outward from the mounting flange. The mixer is disposed adjacent the upstream face with the mounting flange against the retainer. The retention tab is engaged in the slot to prevent axial withdrawal of the mixer from the retainer.

Abstract: There is provided a voltage or current sensing device. An exemplary voltage or current sensing device includes a drive circuitry configured to deliver a drive current to a magnetic core operably coupled with a conductor, for driving the core to cyclical magnetic saturation. The device also includes sense circuitry configured to receive a voltage signal corresponding to an application current in the conductor. The device also includes signal processing circuitry configured to sample the voltage signal, wherein a first sample is in phase with the drive current and a second sample is out of phase with the drive current. The device also includes a feedback loop configured to deliver a compensation current to the magnetic core, wherein the compensation current is configured to balance the magnetic core and wherein the compensation current is based at least in part on the first sample in phase with the drive current.

Abstract: An electrical connector comprising a housing having at least one terminal receiving passageway, an opening positioned proximate at least one terminal receiving passageway, a primary latch for latching the electric connector to a mating connector, and a slot extending longitudinally along side the primary latch. The connector has a connector position assurance member (CPA) positionable in the opening and having a locking latch which is laterally offset from the primary latch of the housing. The CPA has first and second longitudinal positions. The first position where the CPA is in a partially inserted position and a second position where the housing is in a fully mated position within a mating connector housing and the CPA is in a fully inserted position.

Abstract: The present invention is based, in part, upon the insight that compound DsiRNA agents can be generated using site-specific RNase H-cleavable double-stranded nucleic acid regions to attach, e.g., one DsiRNA moiety to another DsiRNA moiety and/or one DsiRNA moiety to a functional group and/or payload. Because such double-stranded nucleic acid joining sequences are site-specifically RNase H-cleavable, the bifunctional molecule is cleaved into DsiRNAs bearing terminal ends that orient dicer cleavage. Detrimental impacts of administering a single double-stranded nucleic acid RNAi agent of longer than 30-35 nucleotides (e.g., provocation of interferon response) is minimized, as once administered to a subject or RNase H-containing cell, RNase H cleavage produces a shortened, active DsiRNA agent(s). The invention provides bifunctional DsiRNA agents that are joined by double-stranded DNA extension joining sequences, which do not provoke RNase H cleavage.

Abstract: The invention features compositions and methods that are useful for reducing the expression or activity of a specified gene in a eukaryotic cell, involving contacting a cell with an isolated nucleic acid containing a Dicer substrate and a receptor binding region in an amount effective to reduce expression of a target gene in a cell.

Abstract: A valance corner including an engagement portion having first, second and third mating surfaces and a sealing edge, wherein the sealing edge includes first and second sealing extensions arranged orthogonal relative to each other and having first and second ends, respectively, each of the first, second and third mating surfaces are arranged orthogonal relative to the other mating surfaces and the first and second mating surfaces form the first and second ends of the sealing edge, respectively. The valance corner further includes a securing portion having first and second securing extensions arranged orthogonal relative to each other, the securing portion fixedly secured to the engagement portion. The first and second securing extensions are arranged parallel to the first and second sealing extensions, respectively.