Patents by Inventor Darin J. Messina

Darin J. Messina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170239299
    Abstract: Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
    Type: Application
    Filed: February 27, 2017
    Publication date: August 24, 2017
    Applicant: DePuy Synthes Products, Inc.
    Inventors: Anthony J. Kihm, Ian Ross Harris, Sanjay Mistry, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Publication number: 20170224873
    Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.
    Type: Application
    Filed: April 24, 2017
    Publication date: August 10, 2017
    Inventors: Jacob F. Pollock, Lauren E. Kokai, Cunqi Cui, Xiaojie Yu, Dennis E. Van Epps, Darin J. Messina
  • Patent number: 9717763
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: August 1, 2017
    Assignee: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Sanjay Mistry, Anthony J. Kihm, Ian R. Harris, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Publication number: 20170166864
    Abstract: Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 15, 2017
    Applicant: DePuy Synthes Products, Inc.
    Inventors: Anthony J. Kihm, Ian Ross Harris, Sanjay Mistry, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Publication number: 20170166863
    Abstract: Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 15, 2017
    Applicant: DePuy Synthes Products, Inc.
    Inventors: Anthony J. Kihm, Ian Ross Harris, Sanjay Mistry, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Patent number: 9662422
    Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: May 30, 2017
    Assignee: Allergan, Inc.
    Inventors: Jacob F. Pollock, Lauren E. Kokai, Cunqi Cui, Xiaojie Yu, Dennis E. Van Epps, Darin J. Messina
  • Patent number: 9579351
    Abstract: Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: February 28, 2017
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Anthony J. Kihm, Ian Ross Harris, Sanjay Mistry, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Patent number: 9572840
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: February 21, 2017
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Darin J. Messina, Alexander M. Harmon, Ian R. Harris, Anthony J. Kihm, Sanjay Mistry, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Patent number: 9498501
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: November 22, 2016
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Sanjay Mistry, Anthony J. Kihm, Ian R. Harris, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Publication number: 20160193255
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.
    Type: Application
    Filed: January 11, 2016
    Publication date: July 7, 2016
    Inventors: Sanjay Mistry, Darin J. Messina
  • Publication number: 20150064147
    Abstract: Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a collagen component.
    Type: Application
    Filed: November 6, 2014
    Publication date: March 5, 2015
    Applicant: Allergan, Inc.
    Inventors: Jacob F. Pollock, Lauren E. Kokai, CUNQI Cui, Xiaojie Yu, Dennis E. Van Epps, Darin J. Messina
  • Patent number: 8846394
    Abstract: The present invention is directed to methods of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human by administering human recombinant GDF5 to the striatum or substanta nigra pars compacta of a human in amounts effective to induce cell populations having the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards a dopaminergic phenotype, and to neurotrophic compositions and matrices suitable for use in such treatments.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: September 30, 2014
    Assignee: Ethicon, Inc.
    Inventors: Sanjay Mistry, Darin J. Messina
  • Patent number: 8815587
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: August 26, 2014
    Assignee: DePuy Synthes Products, LLC
    Inventors: Ian R. Harris, Darin J. Messina, Anthony J. Kihm, Agnieszka Seyda, David C. Colter
  • Publication number: 20140212392
    Abstract: A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
    Type: Application
    Filed: March 18, 2014
    Publication date: July 31, 2014
    Applicant: University of Utah Research Foundation
    Inventors: Margot Mayer-Proschel, Mahendra S. Rao, Patrick A. Tresco, Darin J. Messina
  • Publication number: 20140206022
    Abstract: The present specification discloses three-dimensional in vitro cell-based methods to assess a test matrix polymer ability to support differentiation of a population of cells methods of screening a material for its ability to stimulate cell growth and/or differentiation.
    Type: Application
    Filed: December 16, 2013
    Publication date: July 24, 2014
    Applicant: Allergan, Inc.
    Inventors: Gina M. Nuti, Mark R. Verardo, Darin J. Messina
  • Publication number: 20140154226
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
    Type: Application
    Filed: January 10, 2014
    Publication date: June 5, 2014
    Applicant: DePuy Synthes Products, LLC
    Inventors: Darin J. Messina, Alexander M. Harmon, Ian R. Harris, Anthony J. Kihm, Sanjay Mistry, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Patent number: 8709807
    Abstract: A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 29, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Margot Mayer-Proschel, Mahendra S. Rao, Patrick A. Tresco, Darin J. Messina
  • Patent number: 8658152
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: February 25, 2014
    Assignee: DePuy Synthes Products, LLC
    Inventors: Darin J. Messina, Alexander M. Harmon, Ian R. Harris, Anthony J. Kihm, Sanjay Mistry, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Publication number: 20140045263
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Application
    Filed: September 5, 2013
    Publication date: February 13, 2014
    Applicant: DEPUY SYNTHES PRODUCTS, LLC.
    Inventors: Sanjay Mistry, Anthony J. Kihm, Ian R. Harris, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Patent number: 8361459
    Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: January 29, 2013
    Assignee: Advanced Technologies and Regenerative Medicine, LLC
    Inventors: Darin J. Messina, Sanjay K. Mistry, L. S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko, Anna Gosiewska