Patents by Inventor Darin J. Messina

Darin J. Messina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGENERATION AND REPAIR OF NEURAL TISSUE USING POSTPARTUM-DERIVED CELLS
    Publication number: 20130022585
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
    Type: Application
    Filed: September 6, 2012
    Publication date: January 24, 2013
    Applicant: Advanced Technologies and Regenerative Medicine, LLC
    Inventors: DARIN J. MESSINA, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • POSTPARTUM CELLS DERIVED FROM UMBILICAL TISSUE AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20120315251
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Application
    Filed: November 15, 2010
    Publication date: December 13, 2012
    Applicant: Advanced Technologies and Regenerative Medicine, LLC
    Inventors: Ian Ross HARRIS, Darin J. Messina, Anthony J. Kihm, Agnieszka Seyda, David C. Colter
  • Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
    Patent number: 8318483
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: November 27, 2012
    Assignee: Advanced Technologies and Regenerative Medicine, LLC
    Inventors: Sanjay Mistry, Anthony J. Kihm, Ian Ross Harris, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Anna Gosiewska
  • Regeneration and repair of neural tissue using postpartum-derived cells
    Patent number: 8277796
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: October 2, 2012
    Assignee: Advanced Technologies and Regenerative Medicine, LLC
    Inventors: Darin J. Messina, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Method of Isolating Human Neuroepithelial Precursor Cells from Human Fetal Tissue
    Publication number: 20120198577
    Abstract: A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
    Type: Application
    Filed: March 30, 2012
    Publication date: August 2, 2012
    Inventors: Margot Mayer-Proschel, Mahendra S. Rao, Patrick A. Tresco, Darin J. Messina
  • Method of isolating human neuroepithelial precursor cells from human fetal tissue
    Patent number: 8168174
    Abstract: A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
    Type: Grant
    Filed: March 1, 2009
    Date of Patent: May 1, 2012
    Assignee: University of Utah Research Foundation
    Inventors: Margot Mayer-Proschel, Mahendra S. Rao, Patrick A. Tresco, Darin J. Messina
  • Treatment of Parkinson's disease and related disorders using postpartum derived cells
    Patent number: 7875273
    Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: January 25, 2011
    Assignee: Ethicon, Incorporated
    Inventors: Darin J. Messina, Sanjay Mistry, L. S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko
  • Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
    Patent number: 7875272
    Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: January 25, 2011
    Assignee: Ethicon, Incorporated
    Inventors: Darin J. Messina, Sanjay Mistry, L. S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko, Anna Gosiewska
  • REGENERATION AND REPAIR OF NEURAL TISSUE USING POSTPARTUM-DERIVED CELLS
    Publication number: 20100260843
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
    Type: Application
    Filed: April 24, 2009
    Publication date: October 14, 2010
    Applicant: Ethicon, Incorporated
    Inventors: Darin J. Messina, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • TREATMENT OF STROKE AND OTHER ACUTE NEURAL DEGENERATIVE DISORDERS USING POSTPARTUM-DERIVED CELLS
    Publication number: 20100215714
    Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.
    Type: Application
    Filed: January 29, 2010
    Publication date: August 26, 2010
    Applicant: Ethicon, Incorporated
    Inventors: Darin J. MESSINA, Sanjay K. Mistry, L.S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko, Anna Gosiewska
  • POSTPARTUM CELLS DERIVED FROM UMBILICAL CORD TISSUE, AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20100210013
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Application
    Filed: February 19, 2009
    Publication date: August 19, 2010
    Applicant: Ethicon, Incorporated
    Inventors: Sanjay Mistry, Anthony J. Kihm, Ian Ross Harris, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Treatment of Parkinson's disease and related disorders using postpartum derived cells
    Patent number: 7618622
    Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: November 17, 2009
    Assignee: Ethicon, Incorporated
    Inventors: Darin J. Messina, Sanjay Mistry, L. S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko
  • Soft tissue repair and regeneration using postpartum-derived cells
    Patent number: 7560276
    Abstract: Cells derived from postpartum tissue having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: July 14, 2009
    Assignee: Ethicon, Incorporated
    Inventors: Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Sanjay Mistry, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
  • Method of Isolating Human Neuroepithelial Precursor Cells from Human Fetal Tissue
    Publication number: 20090162330
    Abstract: A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
    Type: Application
    Filed: March 1, 2009
    Publication date: June 25, 2009
    Inventors: Margot Mayer-Proschel, Mahendra S. Rao, Patrick A. Tresco, Darin J. Messina
  • TREATMENT OF NEUROLOGICAL DEFICITS IN THE STRIATUM OR SUBSTANTA NIGRA PARS COMPACTA
    Publication number: 20090149371
    Abstract: The present invention is directed to methods of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human by administering human recombinant GDF5 to the striatum or substanta nigra pars compacta of a human in amounts effective to induce cell populations having the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards a dopaminergic phenotype, and to neurotrophic compositions and matrices suitable for use in such treatments.
    Type: Application
    Filed: November 11, 2008
    Publication date: June 11, 2009
    Inventors: Sanjay Mistry, Darin J. Messina
  • Regeneration and repair of neural tissue using postpartum-derived cells
    Patent number: 7524489
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: April 28, 2009
    Assignee: Ethicon Incorporated
    Inventors: Darin J. Messina, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi
  • Method of isolating human neuroepithelial precursor cells from human fetal tissue
    Patent number: 7517521
    Abstract: A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: April 14, 2009
    Assignee: University of Utah Research Foundation
    Inventors: Margot Mayer-Proschel, Mahendra S. Rao, Patrick A. Tresco, Darin J. Messina
  • Postpartum cells isolated from umbilical cord tissue, and methods of making and using the same
    Patent number: 7510873
    Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: March 31, 2009
    Assignee: Ethicon, Incorporated
    Inventors: Sanjay Mistry, Anthony J. Kihm, Ian Ross Harris, Alexander M. Harmon, Darin J. Messina, Chin-Feng Yi, Anna Gosiewska
  • Treatment of Neurological Deficits in the Striatum or Substanta Nigra Pars Compacta
    Publication number: 20080254538
    Abstract: The present invention is directed to methods of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human by administering BMP7 to the striatum or substanta nigra pars compacta of a human in amounts effective to induce cell populations having the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards a dopaminergic phenotype, and to neurotrophic compositions and matrices suitable for use in such treatments.
    Type: Application
    Filed: April 7, 2008
    Publication date: October 16, 2008
    Inventors: Darin J. Messina, Sanjay Mistry
  • Treatment of retinitis pigmentosa with human umbilical cord cells
    Patent number: 7413734
    Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: August 19, 2008
    Assignee: Ethicon, Incorporated
    Inventors: Sanjay Mistry, Darin J. Messina, Ian Ross Harris, Alexander M. Harmon, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska