Abstract: Provided herein are modified T cell engagers, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same. The modified T cell engagers described herein are modified with a peptide and a half-life extending molecule.

Abstract: A method for acquiring an X-ray image of anatomical features and surgical effectors in a surgical space of a patient includes detecting a particular pose of a particular C-arm used to acquire the X-ray of the surgical space. Characterization parameters of the particular C-arm in the particular pose are determined and incorporated into equations implemented in imaging software that is operable to generate an image of the anatomical features and surgical effectors in the surgical space. When the live X-ray of the surgical space is acquired, the imaging software generates a live image of the anatomical features and surgical effectors as a function of the characterization parameters to account for potential deviations due to the pose of the C-arm. In another feature, a potential error in the imaging process can be visually or automatically detected.

Abstract: A sensor device having one or more sensor elements to provide first positioning information indicative sensor device position with respect to an object of interest is detachably mounted to an appliance on which the object is disposed. A moveable member of the appliance is actuated to effect change in relative positioning of the sensor device and object while one or more appliance-integrated sensor components generate second positioning information indicative of change in spatial position of the moveable member. A processing unit synthesizes, from the first and second positioning information, third positioning information indicative of a spatial position of at least one of the sensor device or the moveable member after actuation of the moveable member.

Abstract: The construction of a medical device having a disposable element is disclosed. Detachable elements comprising a body having a retention feature, an electrical contactor, and sensors are also disclosed. Further disclosed are detachable elements comprising a body having a hole and a retention pocket, an electrical contactor, and a printed circuit board assembly (PCB) in contact with the innermost surface of the body that forms the retention pocket. Further disclosed are detachable elements comprising a body having an opening and a printed film comprising conductive elements, where the conductive elements comprise a sensor configured to be aligned with the opening to expose the sensor. Further disclosed are reusable components having matching retention features.

Abstract: Disclosed herein is an apparatus for containing and dispensing reagent into a microfluidic cartridge for use in sample-to-answer or point-of-care instruments. The apparatus contains a reagent dispensing unit, such as a reagent blister. The blister can contain one or more vessels for containment of reagents and a rupturable seal that blocks the flow of reagent from the reagent blister through an interface and into the microfluidic cartridge.

Abstract: Disclosed are example efficient circuits that produce spark discharges for hydrocarbon conversion (or treatment of other mixtures) using a high-voltage rectified DC supply to discharge a capacitor (either internal or external) across a two-electrode gap, optimized to minimize waste energy by operating in a constant current, approximately-constant current, or constant power mode. The circuits may operate off of a standard electrical supply line (e.g. 120 VAC or 240 V AC, 60 Hz, single-phase or multi-phase). The disclosed approach is scalable to any number of discharge gaps while maintaining similar pulse characteristics and electrical efficiency.

Abstract: A content tracking system may include a processor. A content tracking system may include a non-transitory memory coupled to the processor, including one or more content containers. A content tracking system may include a communication service coupled to a network interface, the communication service configured to receive content-related service requests. A content tracking system may include a content container service communicatively coupled to the processor. A content tracking system may include a registry container service communicatively coupled to the processor, wherein the processor is configured to. generate a content container package, associate a data content portion with the content container package, generate side car file data, associate the side car file data with the content container package; and log a plurality of content-related metadata attribute values to a registry database.

Abstract: A generative content tracking system may include one or more of a plurality of content container generating instructions, a processor configured to execute the content container generating instructions, and a non-transitory memory coupled to the processor configured to store the content container generating instructions. A generative content tracking system may include a communication service coupled to a network interface, the communication service configured to receive a content container generation request.

Abstract: A generative content registration system may include a processor. A generative content registration system may include a non-transitory memory coupled to the processor configured to store a generative content registration database comprising generative content registration data. A generative content registration system may include a communication service coupled to a network interface, the communication service configured to receive generative content registration-related service requests.

Abstract: A method and apparatus to shield various components (e.g., a gasket, a sensor, a wire, a mechanical component made of metals and/or polymers) deployed in a vacuum environment using a shield assembly formed from multiple ceramic fibers. The shield assembly reduces damage to the components when exposed to a plasma and the generation of contaminants. The ceramic fibers are formed from a ceramic and arranged in a packed structure creating a tortuous trajectory that suppresses the transport of charged particles and/or contaminants through the shield assembly. The ceramic fibers are mechanically compliant and readily bent and/or packed into gaps without fracture. The ceramic fibers may also be formed into a tube to surround a fiberglass rod, a gasket, a sensor, and/or a wire. The presence of the shield assemblies also permits cleaning of the interior surfaces of the vacuum chamber using a plasma without generating contaminants from the gaskets.

Abstract: An injector system for delivering a medical fluid, the injector system including an injector configured to receive at least one syringe, the injector comprising at least one piston for releasably engaging and reciprocally driving a plunger or an end wall of the at least one syringe; and a syringe retaining interface comprising one or more retaining elements configured to engage at least a portion of a distal end portion of the at least one syringe to limit movement of the at least one syringe in a distal direction relative to the injector as the medical fluid is delivered from the reservoir via distal movement of the at least one piston.

Abstract: Techniques for monitoring local and/or remote file systems by a synchronization component (e.g., client/server) of a cloud-based platform are disclosed. In some embodiments, a method of building synchronization events by a synchronization component (e.g., a synchronization server/client) includes obtaining a set of items that have been changed and their new states and retrieving last known states of the set of items that are stored in a reference snapshot inside a filesystem scanner. The method further includes generating differences between the new states and the last known states of the set of items as item changes and utilizing information provided by the item changes to translate the item changes into synchronization events for execution on the opposing file system. A method of handling failed synchronization events by a synchronization component of the cloud-based platform by collapsing a subsequent event with the failed synchronization event is also disclosed.

Abstract: Systems and methods for facilitating interactions between a medical device (e.g., an imaging device, a surgical tool, a robotic arm, etc.) and a patient using radio frequency (RF) co-localization are provided. The systems include a radio-frequency (RF) interrogator system, one or more first RF target devices for coupling to a patient support for supporting a patient with respect to whom a medical device is to perform a task, and one or more second RF target devices for coupling to the medical device. A controller determines a position of the patient support within an RF interrogator system reference frame, a first position of the medical device within the RF interrogator system reference frame, a transformation between the RF interrogator system reference frame and a patient support reference frame, and a second position of the medical device within the patient support reference frame.

Abstract: A multi-fed, multi-segmented magnetic coil assembly includes inertial dampers that can avoid excessive strain on core portions and fasteners that hold core portions of the magnetic coil together. Energy-absorbing elements are used to absorb and dissipate kinetic energy of oscillating components of the magnetic coil that result from high magnetic pressure acting on core segments. The inertial dampers and energy-absorbing elements can be selected to critically damp or overdamp mechanical oscillation in the magnetic coil assembly, allowing continuous repeated production of intense magnetic fields.

Abstract: Systems and methods for automated resource allocation during a computational simulation are described herein. An example method includes performing a simulation with a first set of computing resources. The method also includes dynamically analyzing at least one attribute of the simulation to determine a second set of computing resources for performing the simulation, and performing the simulation with the second set of computing resources. The second set of computing resources is different than the first set of computing resources.

Abstract: An electronic cutting machine includes a static dumping assembly configured to collect static charge from a workpiece placed on a working surface of the machine during use. The dumping assembly of the electronic cutting machine may include a static collection strip at least partially forming or defining the working surface of the cutting machine. The electronic cutting machine may also include a material sensor configured to detect at least one of a presence and a type of workpiece.

Abstract: Provided herein are multispecific antibodies for redirecting T cells to cancers, that rely on binding of one antigen interacting portion of the antibody to a tumor-associated antigen or marker, such as epidermal growth factor receptor (EGFR), while a second antigen interacting portion can bind to an effector cell antigen on a T cell, such as CD3, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same.

Abstract: Provided herein are antibodies that selectively bind to EGFR and CD3, pharmaceutical compositions thereof, as well as methods of producing such antibodies.

Abstract: Systems and methods for monitoring batteries in user devices are disclosed. The user devices include mobile phones and laptops, in examples. The system includes a micro-electro-mechanical system (MEMS) ultrasound source, a MEMS ultrasound sensor, a signal drive and acquisition module (SDM), and a processor. The MEMS source and sensor are included within the user device and are disposed against the battery. The SDM configures the MEMS source to transmit an ultrasound pulse into the battery, and the MEMS sensor detects ultrasound reflected by or transmitted through the battery. The SDM collects the detected pulses, and the processor analyzes the detected pulses to determine states of the battery including a state of health, a state of charge and an instantaneous battery thickness measurement. For example, the SDM and the processor can be included within the user device, and/or the SDM and the signal processor can be incorporated into an integrated circuit.

Abstract: Disclosed is an armored cable assembly which may include a plurality of conductors and a metal sheath disposed over the plurality of conductors. The metal sheath may have a plurality of revolutions extending helically along a lengthwise axis, each of the plurality of revolutions including a first section having a curved profile, a second section extending from the first section, the second section having a planar profile, and a third section extending from the second section. The third section may include a free end angled towards an interior cavity of the metal sheath, the free end extending past a plane defined by a bottom most point of the first section of an adjacent revolution, the plane extending perpendicular to the second section.