Abstract: Disclosed herein are polypeptide and polypeptide complex compositions that comprise a peptide that selectively impairs binding of an anti-CD3 binding domain to CD3 in healthy tissue but not in a disease state.

Abstract: Provided herein are antibodies that selectively bind to PSMA and CD3, pharmaceutical compositions thereof, as well as methods of producing such antibodies.

Abstract: Disclosed herein are polypeptides and polypeptides complexes comprising a half-life extending antibody or antibody fragment. In some embodiments, the half-life extending antibody or antibody fragment is a single domain antibody.

Abstract: Provided herein are multispecific antibodies that selectively bind to TROP2 and effector cell antigens such as CD3, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same.

Abstract: A noise suppressed blasting system comprising: a source of blasting gas in a predetermined pressure range with abrasive particles entrained therein; a nozzle including a nozzle inlet for connection to the source of blasting gas, a nozzle outlet for emission of the blasting gas, a nozzle conduit from the nozzle inlet to the nozzle outlet including a throat therebetween with a ratio of area of the nozzle outlet to area of the throat selected to emit the blasting gas from the nozzle outlet to produce a supersonic jet; a silencer connectable to the nozzle, to receive the supersonic jet exiting the nozzle, the silencer comprising a body with a silencer conduit therethrough, the body being of sufficient length and diameter to cause a flow condition of the jet received from the nozzle outlet to be modified such that 1½ shock cells are created in a jet inside the silencer, no shock cells are created in the jet outside the silencer and a jet exits the silencer in the form of a core jet with an established turbul

Abstract: A gradiometer includes a at least one magnet attached to a beam. The magnet moves in response to a magnetic force. A sensing element is configured to measure movement or deflection of the beam or magnet. The gradiometer is configured to determine a gradient of a magnetic field acting on the first magnet based on movement of the magnet. The gradiometer can further measure higher order gradients.

Abstract: A blast nozzle thrust reduction blasting system comprising: a source of blasting gas in a predetermined pressure range with abrasive particles entrained therein; a nozzle including a nozzle inlet for connection to the source of blasting gas, a nozzle outlet for emission of the blasting gas, a nozzle conduit from the nozzle inlet to the nozzle outlet including a throat therebetween with a ratio of area of the nozzle outlet to area of the throat selected to emit the blasting gas from the nozzle outlet to produce a supersonic jet; a thrust reducer connectable to the nozzle, to receive the supersonic jet exiting the nozzle, the thrust reducer comprising a body with a thrust reducer conduit therethrough, the body being of sufficient length and diameter to cause a flow condition of the jet received from the nozzle outlet to be modified such that a zone of sub-atmospheric pressure forms adjacent a face of the outlet of the nozzle whereby a pressure differential arises between the zone of sub-atmospheric press

Abstract: Provided herein are antibodies that selectively bind to CD28 and PD-L1, pharmaceutical compositions thereof, as well as nucleic acids, and methods of use, and methods for making and discovering the same.

Abstract: Provided herein are antibodies that selectively bind to HER2 and CD3, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same.

Abstract: A method and system of translating addresses is disclosed that includes receiving an effective address for translation, providing a processor and a translation buffer where the translation buffer has a plurality of entries, wherein each entry contains a mapping of an effective address directly to a corresponding real address, and information on a corresponding intermediate virtual address. The method and system further include determining whether the translation buffer has an entry matching the effective address, and in response to the translation buffer having an entry with a matching effective address, providing the real address translation from the entry having the matching effective address.

Abstract: Disclosed is an armored cable assembly which may include a plurality of conductors and a metal sheath disposed over the plurality of conductors. The metal sheath may have a plurality of revolutions extending helically along a lengthwise axis, each of the plurality of revolutions including a first section having a curved profile, a second section extending from the first section, the second section having a planar profile, and a third section extending from the second section. The third section may include a free end angled towards an interior cavity of the metal sheath, the free end extending past a plane defined by a bottom most point of the first section of an adjacent revolution, the plane extending perpendicular to the second section.

Abstract: Disclosed is an armored cable assembly which may include a plurality of conductors and a metal sheath disposed over the plurality of conductors. The metal sheath may have a plurality of revolutions extending helically along a lengthwise axis, each of the plurality of revolutions including a first section having a curved profile, a second section extending from the first section, the second section having a planar profile, and a third section extending from the second section. The third section may include a free end angled towards an interior cavity of the metal sheath, the free end extending past a plane defined by a bottom most point of the first section of an adjacent revolution, the plane extending perpendicular to the second section.

Abstract: A computer system, processor, programming instructions and/or method for managing operations of a gather buffer for a processor core load storage unit. The processor core includes a processing pipeline having one or more execution units for processing unaligned load instructions that executes in two phases to satisfy. A buffer storage element is provided having a plurality of entries for temporarily collecting partial writeback results retrieved from the memory that are associated with first phase accesses for each of a plurality of unaligned load instructions. An associated logic controller device tracks two parts of the unaligned load to be gathered at independent times, wherein said partial result stored at said buffer storage element comprises a first part of an unaligned load. The second phase load access for the same instruction is independently accessed and later merged with first part of the load data at byte granularity to satisfy the load.

Abstract: Disclosed is an armored cable assembly including a core having a notched assembly tape about a plurality of conductors. A metal sheath surrounds the core.

Abstract: Provided herein are antibodies that selectively bind to CD28 and PD-L1, pharmaceutical compositions thereof, as well as nucleic acids, and methods of use, and methods for making and discovering the same.

Abstract: Disclosed herein are isolated polypeptides or polypeptide complexes that comprise a tumor-associated calcium signal transducer 2 (TROP2) binding domain that has been optimized for binding and kinetic properties. In some embodiments, the isolated polypeptides or polypeptide complexes further comprise a CD3 binding domain.

Abstract: Provided herein are multispecific antibodies that selectively bind to PSMA and effector cell antigens such as CD3, pharmaceutical compositions thereof, as well as nucleic acids, and methods for making and discovering the same.

Abstract: A system and method of effectively measuring a change in a gradient of a magnetic field. The systems include a first magnet and a second magnet mechanically coupled together and aligned along a polarization axis. The first magnet and the second magnet are positioned such that a pair of like magnetic poles of the first magnet and the second magnet face in opposite directions. Further, the first magnet and the second magnet are configured to move along the polarization axis in response to a magnetic field. A sensing system is configured to measure a change in a gradient of the magnetic field based on the movement of the first magnet and second magnet along the polarization axis in response to the magnetic field.

Abstract: A computer system, processor, programming instructions and/or method for managing operations of a gather buffer for a processor core load storage unit. The processor core includes a processing pipeline having one or more execution units for processing unaligned load instructions that executes in two phases to satisfy. A buffer storage element is provided having a plurality of entries for temporarily collecting partial writeback results retrieved from the memory that are associated with first phase accesses for each of a plurality of unaligned load instructions. An associated logic controller device tracks two parts of the unaligned load to be gathered at independent times, wherein said partial result stored at said buffer storage element comprises a first part of an unaligned load. The second phase load access for the same instruction is independently accessed and later merged with first part of the load data at byte granularity to satisfy the load.

Abstract: A system includes a flow line connected to a fluid and a suction line in fluid communication with the flow line, wherein the fluid is to carry cuttings from a borehole. The system also includes a flow line pump to move fluid via the suction line onto a surface of a cuttings separation conveyor, wherein the surface of the cuttings separation conveyor comprises a separation screen. The system also includes a cuttings container positioned to collect a portion of the cuttings from the separation conveyor.