Abstract: Embodiments include a spreader and a resealable delivery channel in a catheter positioning system configured to introduce a catheter into the resealable delivery channel. The spreader may have shapes configured to help users insert the spreader and a catheter into the resealable delivery channel and to retain the spreader and the catheter within the resealable delivery channel. The resealable delivery channel may be shaped to accommodate the spreader or catheter. The resealable delivery channel may include flexible plastic lips that are moveable to facilitate insertion of the spreader and a catheter into the resealable delivery channel.

Abstract: Systems, methods, and devices of the various embodiments provide a hoop drive assembly. A hoop drive assembly according to the various embodiments may include one or more toothed rings and one or more motors coupled to the one or more toothed rings. In the various embodiments, rotation of the one or more toothed rings may change an orientation of a turret supported by the hoop drive assembly and/or move a control actuator of a catheter held in a modular plate coupled to the turret.

Abstract: Embodiments include removable catheter actuator collars which may connect a catheter actuator on a catheter's handle to a catheter positioning device. The removable catheter actuator collars may allow the catheter to be easily removed from the catheter positioning device by a physician. The removable catheter actuator collars may remain connected with the catheter when removed and may allow the catheter to be easily reconnected to the catheter positioning system. In further embodiments, the removable catheter actuator collars may be annular or ring shaped and secure to a catheter actuator with various mechanisms such as one or more clamps, compression grips, or rotating portions and may remain connected with the catheter when the catheter is removed from the catheter positioning system.

Abstract: A system for remotely controlling the positioning within the body of a patient of an elongated medical device optionally having a control handle, comprises a robotic system and a remote controller configured to control the robotic device. The robotic system comprises a handle controller; a sled member coupled to the handle controller, the sled member being configured to position the medical device within the body of the patient; and a sled base configured to advance the sled member towards the body of a patient, the sled bed being coupled to a sterile barrier effective to maintain sterility inside the sled base. A medical device introducer is effective to guide the elongated medical device into a patient's body.

Abstract: Systems, methods, and devices of the various embodiments provide linearly stationary catheter drive assemblies enabled to move a catheter's sheath along a linear axis while holding the catheter handle stationary along that linear axis. In the various embodiments, the linearly stationary catheter drive assembly may be configured to move the catheter's sheath along the linear axis while holding the catheter handle stationary along the linear axis and rotating the catheter handle about the linear axis. In an embodiment, a linearly stationary catheter drive assembly may include a loop drive configured to move the catheter sheath along the linear axis. In an embodiment, a linearly stationary catheter drive assembly may include a pinch drive configured to move the catheter sheath along the linear axis.

Abstract: Systems, methods, and devices of the various embodiments provide a remote controller for a catheter positioning system configured to be operated with a single hand by a catheter positioning system operator. In an embodiment, the remote controller may include a thumb joystick control, first wheel control, and second wheel control. In an embodiment, the remote controller may include various visual indicators and/or haptic feedback mechanisms providing information to a catheter positioning system operator.

Abstract: Various embodiments enable an introducer for a catheter to be rotated around an axis and/or traversed backward and/or forward along the axis. In various embodiments, positioning of an introducer may be enabled by an introducer support configured to be rotated around an axis and/or extended or retracted along the axis. The introducer may be manually operated and/or operated by motors in a nose cone of a catheter positioning system. In various embodiments, a portion of the introducer support may be configured to flex. In other embodiment, positioning of an introducer may be enabled by an adjustable nose cone of a catheter positioning system.

Abstract: A carbonated protein beverage composition and a method of making it relate to a beverage prepared using a cold-fill preparation and packaging process and carbonation in the container prior to sealing, providing a protein beverage composition with a protein content of about 2.0% by weight to about 6% by weight protein, carbon dioxide at level of between about 1.6 volumes to about 3.5 volumes, a pH of between about 2.0 to about 3.4, and at least one additional ingredient, wherein both, at the time of packaging of the protein beverage composition and during subsequent storage without refrigeration for a time period of at least 18 months after packaging, substantial solubility of the protein is maintained in the beverage composition, and the protein beverage is essentially free of active microbes known to be harmful to human health in the absence of a preservative, wherein the essentially free from active microbe condition is created by the inactivation of microbes by carbonation.

Abstract: Various embodiments provide a catheter positioning device with components for controlling actuators of the catheter in multiple axes. A catheter may be attached to a sled member by a modular plate with one or more actuator interfaces that may couple with the actuators of a catheter handle. One or more motors or drives in the sled member may move the actuator interfaces of the modular plate to control one or more actuators on the catheter in different axes. In various embodiments the sled member may have a clam shell design in which two or more sides of the sled member close around the catheter handle. In further embodiments, the sled member may include adjustable faces that can fit different types of modular plates and thereby control actuators on different types of the catheter.

Abstract: Various embodiments provide systems and methods for controlling a catheter with a catheter positioning device by using a remote controller. As the catheter is advanced by the catheter positioning device, a counterweight may be adjusted to balance the catheter positioning system. In further embodiments, the counterweight may be configured to move to balance a sled member such that any total moment exerted on a sled base remains constant. In further embodiments, the counterweight may be controlled by a control system based on one or more sensors coupled with the catheter positioning system.

Abstract: The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit.

Abstract: An imaging system is provided with an ultrasound catheter and a controller coupled to the ultrasound catheter. The catheter includes a localizer sensor configured to generate positional information for the ultrasound catheter, and an imaging ultrasound sensor having a restricted field of view. The controller co-registers images from the imaging ultrasound sensor with positional information from the localizer sensor.

Abstract: The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit.

Abstract: The present invention relates to anti-FGFR2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: The present invention relates to anti-FGFR2 and FGFR4 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: A method of manufacturing a polyurethane compound comprises mixing together a polyol, a polyisocyanate compound and a catalyst and allowing the mixture to cure to form a polyurethane, and is characterized in that the catalyst is a neutral complex of a metal selected from Ti, Zr, Hf, Al, Fe, Bi or Sn and a multidentate organic ligand having: a) a number of anionic donor sites=x; b) a number of neutral donor sites, capable of forming a co-ordinate bond with the metal, =y; c) where x+y=from 5 to 8; d) x is from 2 to 4; e) the ligand molecule is of a size and conformation to enable each of the anionic donor sites and neutral donor sites to form a bond with the same metal atom.

Abstract: Embodiments of the subject invention relate to a method and apparatus for providing a golf club shaft that has coupling between one or more bending modes and one or more twisting modes of deformation. In a specific embodiment, bending the shaft along a central longitudinal axis of the shaft in a plane of bending results in twisting of the shaft about the same central longitudinal axis of the shaft.

Abstract: The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL4 and as diagnostics.

Abstract: A device, system and method for duty and tax avoidance is disclosed for a computer-implemented process for converting import tax and duty cost on at least one vehicle/product/good from a taxable entity to a no-cost import tax and duty cost for a Tax Exempt Entity, identified as acronym TEE.

Abstract: A matric potential sensor (100) arranged to measure the matric potential of a medium and comprising a porous material portion (102a, 102b), arranged to absorb moisture from the medium into which, in use, it is inserted, and an electrode element (100) wherein a non-porous compliant material (606, 608) is provided between the porous material (102a, 102b) portion and the electrode element (100).