Abstract: The present invention provides curable compositions comprising non-tin metal accelerators that accelerate the condensation curing of moisture-curable silicones/non-silicones. In particular, the present invention provides an accelerator comprising amino acid compounds that are suitable as replacements for organotin in sealant and RTV formulations.

Abstract: The methods, devices, and systems of the various embodiments may include an esophageal probe including and elongate tube, at least one pair of pacing electrodes and at least one temperature sensor. The elongate tube may include a proximal end for coupling to a handle and a distal end for insertion into an esophagus of a patient. The pair of pacing electrodes may be disposed at the distal end of the elongate tube, along with the temperature sensor. The temperature monitoring equipment may monitor the temperatures sensor, enable pacing to be conducted using the pair of pacing electrodes when measured temperature is within one or more thresholds, and preventing pacing from being conducted when measured temperature is not within the one or more thresholds.

Abstract: A carbonated protein beverage composition and a method of making it relate to a beverage prepared using a cold-fill preparation and packaging process and carbonation in the container prior to sealing, providing a protein beverage composition with a protein content of about 2.0% by weight to about 6% by weight protein, carbon dioxide at level of between about 1.6 volumes to about 3.5 volumes, a pH of between about 2.0 to about 3.4, and at least one additional ingredient, wherein both, at the time of packaging of the protein beverage composition and during subsequent storage without refrigeration for a time period of at least 18 months after packaging, substantial solubility of the protein is maintained in the beverage composition, and the protein beverage is essentially free of active microbes known to be harmful to human health in the absence of a preservative, wherein the essentially free from active microbe condition is created by the inactivation of microbes by carbonation.

Abstract: The present disclosure relates to an antibody or antigen binding fragment having at least two receptor binding domains for two different binding sites of LRP6 and compositions and methods of use thereof.

Abstract: MRI-guided high-intensity focused ultrasound (“HIFU”) therapy can be used to ablate sympathetic nerves near the renal arteries. Such therapy may employ a HIFU device that includes an ultrasound transducer and an expandable reservoir that includes a first surface configured to conform to a surface anatomy of a patient and a port in fluid communication with a fluid source. The expandable reservoir can be configured to change a size in a dimension by inflating or deflating the expandable reservoir. Such a device may be used in connection with an MRI device that includes a support portion configured to conform to the surface anatomy of the patient and defining a first window configured to receive the ultrasound transducer for targeting tissue. The MRI device can include radiofrequency coil arrays embedded throughout to the support portion to monitor the therapy.

Abstract: Non-invasive, outcome-confirmed renal denervation procedures include assessments performed before, during, and after an ablation procedure. Stimulation operations can be performed by ultrasound application apart from ablation and/or heating operations to determine the presence and/or condition of a renal nerve in a targeted region. Consistent nerve ablation can be achieved (e.g., in a spontaneous hypertensive patient) by assessing the pathophysiology of renal denervation via (1) reduction of blood pressure and/or (2) kidney and serum norepinephrine concentration.

Abstract: A carbonated protein beverage composition and a method of making it relate to a beverage prepared using a cold-fill preparation and packaging process and carbonation in the container prior to sealing, providing a protein beverage composition with a protein content of about 2.0% by weight to about 6% by weight protein, carbon dioxide at level of between about 1.6 volumes to about 3.5 volumes, a pH of between about 2.0 to about 3.4, and at least one additional ingredient, wherein both, at the time of packaging of the protein beverage composition and during subsequent storage without refrigeration for a time period of at least 18 months after packaging, substantial solubility of the protein is maintained in the beverage composition, and the protein beverage is essentially free of active microbes known to be harmful to human health in the absence of a preservative, wherein the essentially free from active microbe condition is created by the inactivation of microbes by carbonation.

Abstract: A process for the hydrosilylation of an unsaturated compound comprising reacting (a) a silyl hydride with (b) an unsaturated compound in the presence of (c) a platinum compound and (d) a cyclodiene, with the provisos that (i) when the unsaturated compound is a terminal alkyne, the silyl hydride is other than a halosilane, and (ii) when the platinum compound is a Pt(II)-based compound, the ratio of total moles of cyclodiene to moles of platinum is less than 3:1.

Abstract: A system for remotely controlling the positioning within the body of a patient of an elongated medical device optionally having a control handle, comprises a catheter position system and a remote controller configured to control the robotic device. The catheter position system includes a handle controller; a sled member coupled to the handle controller, the sled member being configured to position the medical device within the body of the patient; and a sled base configured to advance the sled member towards the body of a patient, the sled bed being coupled to a sterile barrier effective to maintain sterility inside the sled base. The catheter position system may include a control system configured to issue positioning commands in response to sensor signals received from the catheter. The catheter position system may also include a motor driven rotatable catheter introducer clamp configured to enable rotation of an introducer.

Abstract: The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL4 and as diagnostics.

Abstract: The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6 construct inhibit the Wnt signaling pathway without potentiation of the Wnt signal. The LRP6 constructs also have an increased half-life to provide more time for the therapeutic benefit.

Abstract: A method of operating a lighting fixture comprising a plurality of discrete illumination sources of distinguishably different color coordinates comprises determining target color coordinates and luminous flux at which to operate the lighting fixture, determining input electrical power values for each of the plurality of discrete illumination sources that substantially produce the target color coordinates and luminous flux by referencing a calibration data lookup table having calibration data based on measurements of the plurality of discrete illumination sources, determining a color mixing zone defined by three distinguishably different color coordinates of the plurality of discrete illumination sources within which the target color coordinates lie according to the calibration data, determining luminous flux ratios for each of the plurality of discrete illumination sources having one of the three distinguishably different color coordinates defining the color mixing zone that substantially produces the target

Abstract: Systems, devices, methods, and non-transitory processor-readable storage media for a computing device to generate repositioning instructions for a remotely-controlled catheter positioning system to position a first catheter co-located with a second catheter within a patient's organ, including performing image analysis on imagery generated based on data from the first catheter, calculating positioning corrections based on the performed image analysis, generating repositioning instructions based on the calculated positioning correction information, and transmitting control signals based on the generated repositioning instructions to the remotely-controlled catheter positioning device. The computing device may also determine whether a representation of the second catheter is within the imagery based on the performed image analysis and whether a representation of a tip of the second catheter is at a desired location within the imagery. In an embodiment, the first catheter may be an ultrasound catheter.

Abstract: A method of operating a lighting fixture comprising a plurality of discrete illumination sources of distinguishably different color coordinates comprises determining target color coordinates and luminous flux at which to operate the lighting fixture, determining input electrical power values for each of the plurality of discrete illumination sources that substantially produce the target color coordinates and luminous flux by referencing a calibration data lookup table having calibration data based on measurements of the plurality of discrete illumination sources, determining a color mixing zone defined by three distinguishably different color coordinates of the plurality of discrete illumination sources within which the target color coordinates lie according to the calibration data, determining luminous flux ratios for each of the plurality of discrete illumination sources having one of the three distinguishably different color coordinates defining the color mixing zone that substantially produces the target

Abstract: Systems, methods, and devices of the various embodiments provide a hoop drive assembly. A hoop drive assembly according to the various embodiments may include one or more toothed rings and one or more motors coupled to the one or more toothed rings. In the various embodiments, rotation of the one or more toothed rings may change an orientation of a turret supported by the hoop drive assembly and/or move a control actuator of a catheter held in a modular plate coupled to the turret.

Abstract: Embodiments include removable catheter actuator collars which may connect a catheter actuator on a catheter's handle to a catheter positioning device. The removable catheter actuator collars may allow the catheter to be easily removed from the catheter positioning device by a physician. The removable catheter actuator collars may remain connected with the catheter when removed and may allow the catheter to be easily reconnected to the catheter positioning system. In further embodiments, the removable catheter actuator collars may be annular or ring shaped and secure to a catheter actuator with various mechanisms such as one or more clamps, compression grips, or rotating portions and may remain connected with the catheter when the catheter is removed from the catheter positioning system.

Abstract: Embodiments include a spreader and a resealable delivery channel in a catheter positioning system configured to introduce a catheter into the resealable delivery channel. The spreader may have shapes configured to help users insert the spreader and a catheter into the resealable delivery channel and to retain the spreader and the catheter within the resealable delivery channel. The resealable delivery channel may be shaped to accommodate the spreader or catheter. The resealable delivery channel may include flexible plastic lips that are moveable to facilitate insertion of the spreader and a catheter into the resealable delivery channel.

Abstract: A system for remotely controlling the positioning within the body of a patient of an elongated medical device optionally having a control handle, comprises a robotic system and a remote controller configured to control the robotic device. The robotic system comprises a handle controller; a sled member coupled to the handle controller, the sled member being configured to position the medical device within the body of the patient; and a sled base configured to advance the sled member towards the body of a patient, the sled bed being coupled to a sterile barrier effective to maintain sterility inside the sled base. A medical device introducer is effective to guide the elongated medical device into a patient's body.

Abstract: Various embodiments enable an introducer for a catheter to be rotated around an axis and/or traversed backward and/or forward along the axis. In various embodiments, positioning of an introducer may be enabled by an introducer support configured to be rotated around an axis and/or extended or retracted along the axis. The introducer may be manually operated and/or operated by motors in a nose cone of a catheter positioning system. In various embodiments, a portion of the introducer support may be configured to flex. In other embodiment, positioning of an introducer may be enabled by an adjustable nose cone of a catheter positioning system.

Abstract: Systems, methods, and devices of the various embodiments provide linearly stationary catheter drive assemblies enabled to move a catheter's sheath along a linear axis while holding the catheter handle stationary along that linear axis. In the various embodiments, the linearly stationary catheter drive assembly may be configured to move the catheter's sheath along the linear axis while holding the catheter handle stationary along the linear axis and rotating the catheter handle about the linear axis. In an embodiment, a linearly stationary catheter drive assembly may include a loop drive configured to move the catheter sheath along the linear axis. In an embodiment, a linearly stationary catheter drive assembly may include a pinch drive configured to move the catheter sheath along the linear axis.