Abstract: Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

Abstract: The regenerative sleeve encompasses the wound site of an amputated appendage and provides an environment conducive to tissue regeneration. The sleeve includes a tubular reservoir having an outer body that encloses the end of the appendage including the wound site and provides a sealed wound space between the wound site and the outer body. The sleeve also includes a cuff disposed in an opening formed in the outer body, the cuff being configured to fit on the appendage, and an access port disposed on the outer body and configured to allow administration of fluids to the wound space. The sleeve assembly was effective in supporting early stages of murine digit tip regeneration when combined with a porcine urinary bladder matrix (UBM) pepsin digest and electrical stimulation.

Abstract: Disclosed herein are methods of preparing silk particles having at least one optical property, e.g., reflectivity, diffraction, refraction, absorption, optical-gain, fluorescence, and light scattering, and compositions resulted therefrom. The compositions and methods of the invention can be utilized in various applications, e.g., medical applications, cosmetics, sunscreen and food additives.

Abstract: The invention relates to silk electronic components and methods for fabricating the same. The silk electronic components can be used as novel devices, such as implantable bioelectric and/or biophotonic devices, biosensors, surveillance devices, invisible cloaks, electromagnetic concentrators or antennas.

Abstract: In an embodiment, a device interrupt manager may be configured to receive an interrupt from a device that is assigned to a guest. The device interrupt manager may be configured to transmit an operation targeted to a memory location in a system memory to record the interrupt for a virtual processor within the guest, wherein the interrupt is to be delivered to the targeted virtual processor. In an embodiment, a virtual machine manager may be configured to detect that an interrupt has been recorded by the device interrupt manager for a virtual processor that is not currently executing. The virtual machine manager may be configured to schedule the virtual processor for execution on a hardware processor, or may prioritize the virtual processor for scheduling, in response to the interrupt.

Abstract: The invention provides transient devices, including active and passive devices that electrically and/or physically transform upon application of at least one internal and/or external stimulus. Materials, modeling tools, manufacturing approaches, device designs and system level examples of transient electronics are provided.

Abstract: Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

Abstract: Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

Abstract: Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

Abstract: Methods of treating individuals with a glucose metabolism disorder, and compositions thereof, are provided.

Abstract: A method and apparatus are provided for controlling a translation lookaside buffer in connection with the execution of an atomic instruction. The method comprises identifying load instructions within a plurality of instructions to be executed, and placing the identified load instructions in a queue prior to execution. An atomic instruction identified in the queue is prevented from executing until the atomic instruction is the oldest instruction in the queue. The apparatus comprises a queue and a translation lookaside buffer. The queue is adapted to: identify an atomic instruction within a plurality of instructions to be executed; prevent execution of the atomic instruction until it is the oldest instruction in the queue; and send a virtual address corresponding to the atomic instruction and an atomic load signal in response to determining that the atomic instruction is the oldest instruction in the queue.

Abstract: Methods of treating individuals with a glucose metabolism disorder such as diabetes, hyperglycemia, hyperinsulinemia or obesity by administering human FAM3D (family with sequence similarity 3, member D) are provided. Specifically a method of treating hyperglycemia resulting in a reduction of plasma glucose is provided. Additionally, a method of treating hyperinsulinemia resulting in a reduction of plasma glucose is provided. In addition, a method of treating glucose intolerance resulting in an increased glucose tolerance is provided. Pharmaceutical compositions are provided.

Abstract: A method and apparatus are described for generating a signal to resync a processor. In one embodiment, a particular load operation is picked from a load queue in the processor, and the particular load operation is completed out of order with respect to other load operations in the load queue. A load ordering block (LOB) in the processor receives a physical address of the completed load operation, and receives a probe data address that indicates an address of a requested data line. The LOB generates a signal to resync the processor when the physical address of the completed load operation matches the probe data address, (i.e., when bits, that have been set in a bit vector (e.g., Bloom filter) of the LOB by hashing the physical address of the completed load operation, match bits generated by hashing the probe data address).

Abstract: Biodegradable electronic devices may include a biodegradable semiconducting material and a biodegradable substrate layer for providing mechanical support to the biodegradable semiconducting material.

Abstract: A processing core in a multi-processing core system is configured to execute a sequence of instructions as a single atomic memory transaction. The processing core validates that the sequence meets a set of one or more atomicity criteria, including that no instruction in the sequence instructs the processing core to access shared memory. After validating the sequence, the processing core executes the sequence as a single atomic memory transaction, such as by locking a source cache line that stores shared memory data, executing the validated sequence of instructions, storing a result of the sequence into the source cache line, and unlocking the source cache line.

Abstract: A processing core in a multi-processing core system is configured to execute a sequence of instructions as an atomic memory transaction. Executing each instruction in the sequence comprises validating that the instruction meets a set of one or more atomicity criteria, including that executing the instruction does not require accessing shared memory. Executing the atomic memory transaction may comprise storing memory data from a source cache line into a target register, reading or modifying the memory data stored in the target register as part of executing the sequence, and storing a value from the target register to the source cache line.

Abstract: A method of manufacturing a nanopatterned biophotonic structure includes forming a customized nanopattern mask on a substrate using E-beam lithography, providing a biopolymer matrix solution, depositing the biopolymer matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with the nanopattern mask, or a nanopattern is machined directly on a surface of the film using E-beam lithograpy such that the biopolymer film exhibits a spectral signature corresponding to the E-beam lithograpy nanopattern. The resulting bio-compatible nanopatterned biophotonic structures may be made from silk, may be biodegradable, and may be bio-sensing devices. The biophotonic structures may employ nanopatterned masks based on non-periodic photonic lattices, and the biophotonic structures may be designed with specific spectral signatures for use in probing biological substances, including displaying optical activity in the form of opalescence.

Abstract: A method and apparatus are provided for controlling a translation lookaside buffer in connection with the execution of an atomic instruction. The method comprises identifying load instructions within a plurality of instructions to be executed, and placing the identified load instructions in a queue prior to execution. An atomic instruction identified in the queue is prevented from executing until the atomic instruction is the oldest instruction in the queue. The apparatus comprises a queue and a translation lookaside buffer. The queue is adapted to: identify an atomic instruction within a plurality of instructions to be executed; prevent execution of the atomic instruction until it is the oldest instruction in the queue; and send a virtual address corresponding to the atomic instruction and an atomic load signal in response to determining that the atomic instruction is the oldest instruction in the queue.

Abstract: The present invention provides embodiments of an apparatus used to implement a pipelined serial ring bus. One embodiment of the apparatus includes one or more ring buses configured to communicatively couple registers associated with logical elements in a processor. The ring bus(s) are configured to concurrently convey information associated with a plurality of load or store operations.

Abstract: Ceramic nanocomposite and methods for manufacturing thereof. One method comprising: receiving a fired green ceramic body comprising ceramic matrix; introducing to the fired green ceramic body submicron particles; and introducing at least one type of location-controlling dopant at an amount that is sufficient to cover the majority of the ceramic matrix grain boundaries, as well as the majority of the interfaces between the submicron particles and the ceramic matrix grains but less than an amount that would result in a concentration that exceeds the bulk solubility limit of the location-controlling dopant ions in the ceramic matrix, at the ceramic nanocomposite sintering temperature.