Abstract: The present invention relates to compositions and methods of isolated polynucleotides that encode or polypeptides comprising glypican-3 (GPC3). The invention also includes a chimeric antigen receptor (CAR) wherein the CAR is able to target GPC3. The invention further includes methods of treating a subject or diagnosing and treating diseases, disorders or conditions associated with dysregulated glypican-3.

Abstract: A processor employs a security module to manage authentication and encryption keys for the processor. The security module can authenticate itself to other processing systems, such as processing systems providing software to be executed at the processor, can generate keys for encrypting address spaces for the provided software, and can securely import and export information at the encrypted address spaces to and from the processing system. By using a security module that is separate from the processor cores of the processor to perform these security operations, the processing system allows software executing on the processor cores to manage operations based on the authentication and encryption keys without being able to read the keys themselves, thereby preventing unauthorized access by malicious software to the keys.

Abstract: The invention relates to methods and compositions for preparing silk-based piezoelectric materials and methods for increasing piezoelectricity in silk matrices.

Abstract: An adjustable light fixture including a base and a mounting member configured to movably connect a light source to the base. The mounting member is configured to rotate about a rotational axis that moves relative to the base. The adjustably light fixture can be implemented as an overhead light fixture by connecting the base to a ceiling. Also provided is a method adjusting an overhead light fixture including rotating a mounting member and translating the mounting member relative to a base.

Abstract: 3D printing of biopolymer-based inks provides for manufacturing a broad range of products with desirable properties. A print nozzle may be charged to form a cone-shaped ink droplet to result in increased resolution, more reliable contact with irregular surfaces, and a mechanism to control contacting the ink to the print surface.

Abstract: Systems, apparatuses, and methods for implementing hypervisor post-write notification of processor state register modifications. A write to a state register of the processor may be detected during guest execution. In response to detecting the write to the state register, the processor may trigger microcode to perform the write and copy the new value of the register to a memory location prior to exiting the guest. The hypervisor may be notified of the update to the state register after it occurs, and the hypervisor may be prevented from modifying the value of the guest's state register. The hypervisor may terminate the guest if the update to the state register is unacceptable. Alternatively, the hypervisor may recommend an alternate value to the guest. If the guest agrees, the guest may set the state register to the alternate value recommended by the hypervisor when the guest resumes operation.

Abstract: Detection apparatus includes a microfluorometer having an objective, an excitation radiation source, and a detector. The detection apparatus also includes a fluidic system for delivering reagents from a reagent cartridge to a flow cell. The fluidic system includes a manifold body having a plurality of fluidic channels configured for fluid communication between the reagent cartridge and the flow cell. The fluidic system also includes a plurality of reagent sippers. The fluidic system also includes a valve configured to mediate fluid between reagent reservoirs and the flow cell. The detection apparatus also includes a flow cell latch clamp module having a clamp cover for holding the flow cell. The objective is configured to direct excitation radiation from the radiation source to the flow cell and to direct emission from the flow cell to the detector. The microfluorometer is movable to acquire wide-field images of different areas of the flow cell.

Abstract: The invention provides transient devices, including active and passive devices that electrically and/or physically transform upon application of at least one internal and/or external stimulus. Materials, modeling tools, manufacturing approaches, device designs and system level examples of transient electronics are provided.

Abstract: The present disclosure provides apparatuses and methods related to a beverage tap handle that is capable of displaying videos proactively and retroactively based on environmental triggers. In a general embodiment, a beverage tap handle includes a handle portion that can be pulled to dispense a beverage from a spigot, an attachment portion that attaches the handle portion to the spigot, a display screen configured to display a plurality of images, and a controller that controls the display screen to change an image displayed on the display screen to a new image from the plurality of images, the controller programmed to (i) change the displayed image to the new image when the handle portion is pulled sideways to dispense the beverage; and/or (ii) change the displayed image to the new image after the displayed image has been displayed for a predetermined amount of time.

Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.

Abstract: The invention relates to silk electronic components and methods for fabricating the same. The silk electronic components can be used as novel devices, such as implantable bioelectric and/or biophotonic devices, biosensors, surveillance devices, invisible cloaks, electromagnetic concentrators or antennas.

Abstract: A processing system includes a processor that implements registers to define a state of a virtual machine (VM) running on the processor. The processor detects exit conditions of the VM. The processing system also includes a memory element to store contents of the registers in a first data structure that is isolated from a hypervisor of the VM in response to the processor detecting an exit condition. The VM is to selectively expose contents of a subset of the registers to the hypervisor.

Abstract: The present disclosure presents methods, apparatuses, and systems to bolster communication security, and more particularly to utilize a constant time cryptographic co-processor engine for such communication security. For example, the disclosure includes a method for secure communication, comprising receiving encrypted data at a receiving device; obtaining a randomization for at least one bit of the encrypted data; modifying an execution of a cryptographic algorithm on the at least one bit to obtain a randomized cryptographic algorithm based on the randomization; and executing the randomized cryptographic algorithm on the at least one bit of encrypted data to recover original data associated with the encrypted data.

Abstract: A luminaire with a plurality of light-producing subsystems includes a single-channel driver to electrically power each of the plurality of the light-producing subsystems and a distribution device that receives electrical power from the single-channel driver and that distributes the electrical power to the plurality of light-producing subsystems. The distribution device is preferably responsive to controllable distribution settings, such that the amount of power distributed to each light emitting subsystem may be selectively varied and controlled in response to control input. A method of providing a desired output of light from a luminaire including such a distribution device is also provided.

Abstract: A system and method are disclosed for securely receiving data from an input device coupled to a computing system. The system includes an interface configured to receive data from an input device, a coprocessor, and a host computer, wherein the host computer includes an input handler and a host processor. The host processor is configured to execute code in a normal mode and in a privileged mode. The host processor switches from the normal mode to the secure mode upon data being available from the interface while the host computer is in a secure input mode. The input handler receives the data from the interface and sends the received data to the coprocessor responsive to receiving the data while operating in the secure mode.

Abstract: Apparatus, computer-readable storage medium, and method associated with orienting a display image are described. In embodiments, a computing device may include a speech recognition module to process and recognize a voice command and a voice command module coupled with the speech recognition module. The voice command module may be configured to select, in response to recognition of an initial portion of the voice command, a plurality of voice commands having the same initial portion. The voice recognition module may be further configured to initiate execution of or stage for execution individual voice commands of the plurality of voice commands. On recognition of the entire voice command, the voice command module may be configured to select a result of the execution of an individual voice command or initiate execution of a staged for execution voice command.

Abstract: Technologies for offloading execution of program code from a client computing device include a server to execute program code received from the client computing device. The server monitors execution of the program code to determine whether an instruction of the program code to be executed requires a system call. In response to determining the instruction requires execution of a system call, the server transmits the instruction to the client computing device for execution. The server receives a response from the client computing device in response to execution of the instruction that requires execution of the system call by the client computing device.

Abstract: Disclosed herein are nanofibrillar materials and aerogel-like materials comprised of nanofibrils, and methods for making such materials.

Abstract: This application relates to silk fibroin particles that are structurally uniform. Related methods are also disclosed.

Abstract: A system includes a processor including at least a first core and a local interrupt controller associated with the first core. The first core is operable to store its architectural state prior to entering a first core sleep state, and the processor is operable to receive and implement a request for entering a system sleep state in which the first core is in the first core sleep state and the local interrupt controller is powered down and exit the system sleep state by restoring the local interrupt controller and restoring the saved architectural state of the first core.