Abstract: Implementations include methods of controlling a haptic response comprising receiving a force signal from a force sensor; determining a force magnitude associated with the force signal; comparing the force magnitude with an initial threshold force amount to determine whether the force magnitude exceeds the initial threshold force amount; measuring an elapsed time that the force magnitude exceeds the initial threshold force amount; comparing the elapsed time to a minimum elapsed time; if the elapsed time being greater than the minimum elapsed time, generating a haptic feedback control signal, the haptic feedback control signal causing a haptic actuator to propagate a plurality of pressure waves at a propagation frequency, the propagation frequency being proportional to the force magnitude; and generating a scroll control signal that causes a menu system to scroll through a plurality of menu options provided by the menu system at a scroll frequency associated with the propagation frequency.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein R1 R2, R4 and X1 are defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A multimode clutch assembly is positioned in a powertrain of a rotorcraft. The clutch assembly includes a freewheeling unit having a driving mode in which torque applied to the input race is transferred to the output race and an overrunning mode in which torque applied to the output race is not transferred to the input race. A bypass assembly has an engaged position that couples the input and output races of the freewheeling unit. An actuator assembly shifts the bypass assembly between engaged and disengaged positions. An engagement status sensor is configured to determine the engagement status of the bypass assembly. In the disengaged position, the overrunning mode of the freewheeling unit is enabled such that the clutch assembly is configured for unidirectional torque transfer. In the engaged position, the overrunning mode of the freewheeling unit is disabled such that the clutch assembly is configured for bidirectional torque transfer.

Abstract: A failsafe multimode clutch assembly positioned in a powertrain of a rotorcraft. The clutch assembly includes a freewheeling having a driving mode in which torque applied to the input race is transferred to the output race and an overrunning mode in which torque applied to the output race is not transferred to the input race. A bypass assembly has an engaged position that couples the input and output races of the freewheeling unit. An actuator assembly uses pressurized lubricating oil to shift the bypass assembly between the engaged position and a disengaged position. A lock assembly enables and disables actuation of the bypass assembly. In the disengaged position, the overrunning mode of the freewheeling unit enables a unidirectional torque transfer mode of the clutch assembly. In the engaged position, the overrunning mode of the freewheeling unit is disabled such that the clutch assembly is configured for bidirectional torque transfer.

Abstract: Embodiments of the present disclosure are directed toward purge units of vapor compression systems, and methods of control thereof, that improve efficiency by selectively activating and deactivating the purge unit in response to one or more conditions to, for example, enable refrigerant-to-air ratios within the purge unit within certain industry standards while still minimizing the durations of the purge cycles. For example, in certain embodiments, these conditions may include conditions within the chiller condenser, time since last purge activation, time since last venting of non-condensables, and combinations thereof.

Abstract: A valve assembly for a dispenser. The valve assembly includes a valve body. The valve body includes a first hoop member, a second hoop member, and a transition portion defined by the joining of the first hoop member and the second hoop member. The first hoop member includes a first hoop outer portion positioned, a first hoop inner portion, a first hoop upper surface, and a first hoop lower surface. The second hoop member includes a second hoop outer portion, a second hoop inner portion, a second hoop upper surface, and a second hoop lower surface. The second hoop inner portion extends about the longitudinal axis defining a passageway. The passageway comprises a first passageway opening, a second passageway opening opposite the first passageway opening, and a passageway surface extending from the first passageway opening to the second passageway opening.

Abstract: A loading-dock signaling system includes an internal signal light, an external signal light and a wheel chock having a base and a handle extending from the base. A chock signal light is positioned on the handle. The internal signal light, the external signal light and the chock signal light are in signal communication with one another to provide at least a plurality of illuminated indicia to an exterior dock area and an interior dock area. The exterior dock area and the interior dock area are separated by a dock door.

Abstract: Embodiments of the present disclosure relate to techniques for neuromodulation delivery. Based on image data acquired from the subject, control parameters controlling energy application of neuromodulating energy may be dynamically changed during the course of the delivery to maintain desired characteristics of the neuromodulating energy. For example, the beam of the neuromodulating energy may be dynamically adjusted to account for movement of an organ during breathing. In another embodiment, a desired region of interest is identified within the subject based on a trained neural network and the acquired image data.

Abstract: A computer system may access data corresponding to a portfolio that comprises interest rate swaps and may calculate parameters for a compressed swap. The computer system may determine, based at least in part on the parameters for the compressed swap, a performance bond requirement attributable to the interest rate swaps. The computer system may compare the performance bond requirement to account data associated with a holder of the portfolio and may perform one or more additional actions based on the comparing.

Abstract: The present disclosure relates to an inhibitor of human TRPM3 for use in the treatment or prevention of migraine, including in subjects whose migraines are not responsive to CGRP inhibition or whose migraines are responsive to triptans. Combination therapies are also described. In other aspects, the present disclosure provides methods for identifying suitable patients, methods for identifying inhibitors of human TRPM3, cell lines and agonists for use in such methods and a method for measuring PACAP release.

Abstract: Described apparatuses and methods form adaptive cache lines having a configurable capacity from hardware cache lines having a fixed capacity. The adaptive cache lines can be formed in accordance with a programmable cache-line parameter. The programmable cache-line parameter can specify a capacity for the adaptive cache lines. The adaptive cache lines may be formed by combining respective groups of fixed-capacity hardware cache lines. The quantity of fixed-capacity hardware cache lines included in respective adaptive cache lines may be based on the programmable cache-line parameter. The programmable cache-line parameter can be selected in accordance with characteristics of the cache workload.

Abstract: Various embodiments enable versioning of data stored on a memory device, where the versioning allows the memory device to maintain different versions of data within a set of physical memory locations (e.g., a row) of the memory device. In particular, some embodiments provide for a memory device or a memory sub-system that uses versioning of stored data to facilitate a rollback operation/behavior, a checkpoint operation/behavior, or both. Additionally, some embodiments provide for a transactional memory device or a transactional memory sub-system that uses versioning of stored data to enable rollback of a memory transaction, commitment of a memory transaction, or handling of a read or write command associated with respect to a memory transaction.

Abstract: Various implementations include a switch assembly that includes a housing and at least two printed circuit boards (PCBs) that are disposed within the housing and are axially arranged relative to each other. One or more force sensors are disposed on one of the PCBs, and, in some implementations, the one or more force sensors receive force input received by a touch overlay plate. Signals from the force sensors are processed to determine a magnitude, acceleration, and/or location of the force input, and a haptic feedback response is received by the touch overlay plate. The haptic feedback response is based on the force magnitude, acceleration, and/or location of input, according to some implementations. Axially arranging the PCBs reduces the footprint of the switch assembly and allows for the inclusion of more electrical components in the switch assembly, according to some implementations.

Abstract: Systems and methods of flow testing different workpieces in an automated testing station are described. Each workpiece comprises a flow path from an inlet to an outlet and the automated testing station comprises first and second sealing heads for injecting gas into the inlets of workpieces and collecting gas from the outlets of workpieces. The method includes performing a flow test by moving the flow test heads toward the workpieces while at the same time priming a flow of gas from the first sealing heads to the second sealing heads, prior to engaging the workpiece.

Abstract: Disclosed is a BBQ Grill comprising two lower side panels, two upper side panels that are slideably received in the lower side panels. Crossbraces space the panels apart and a grill plate is adapted to detachably engage hooks on the upper side panels. The grill has legs that extend and retract associated with the lower side panels and the upper side panels have a handle assembly with a button to set pawls of a latch plate at selected apertures associated with the lower side panel. Various accessories are disclosed. The grill can be used with wood, charcoal briquettes or a gas burner.

Abstract: An oral care tray that includes a top surface, a first compartment having a first bottom surface spaced from the top surface at a first vertical distance, and a second compartment having a second bottom surface spaced from the top surface at a second vertical distance. The oral care tray also includes a divider separating the first compartment and the second compartment thereby forming a first sidewall in the first compartment and a second sidewall in the second compartment, where the divider extends from the first bottom surface and the second bottom surface toward the top surface.

Abstract: A drilling system includes a guide-hub that includes contact feet configured to be placed against a drilling surface to maintain a fixed angle with the drilling surface. A drilling insert includes a drill bit and a harness. The drilling insert is configured to be inserted into the guide-hub and the harness is configured to detect when the drill bit punctures the drilling surface and automatically prevent further drilling.

Abstract: Systems and methods are disclosed for providing voice and noise activity detection with audio automixers that can reject errant non-voice or non-human noises while maximizing signal-to-noise ratio and minimizing audio latency.

Abstract: The present disclosure relates to AM-14 pharmaceutical formulations and therapeutic dosing regimens for the treatment of disease.

Abstract: A substrate with coated edge surfaces, an apparatus for performing the coating, and a method therefor are described. The substrate may include edge surface electrical connectors, wherein the edge coating is coated overtop the edge surface electrical connectors. The apparatus for performing the coating operation includes a rotary fixture configured to facilitate coating of all edge surfaces of a stack of substrate prior to curing of the edge surface coating, wherein according to the method, edge surfaces of one group of corresponding edge surfaces in the stack are coated with a coating material, the rotary fixture is then rotated to position a second group of edge surfaces for coating, and so forth. The coating process is controlled to obtain a consistent overflow onto major surfaces of the stacked substrates.