Abstract: Provided herein, in certain embodiments, are programmable nucleases, guide nucleic acids, and complexes thereof. Certain programmable nucleases provided herein comprise a RuvC domain. Also provided herein are nucleic acids encoding said programmable nucleases and guide nucleic acids. Also provided herein are methods of genome editing, methods of regulating gene expression, and methods of detecting nucleic acids with said programmable nucleases and guide nucleic acids.

Abstract: Methods are provided for delivering a treatment therapy to treat an organ diagnosed with a disease state. The methods include delivering a first therapeutic agent into systemic circulation at a first flow rate, and delivering a second therapeutic agent directly into a vessel feeding the organ at a higher second flow rate than the first flow rate in a manner that prevents the second treatment agent from circulating systemically.

Abstract: Polypeptides are provided that include an amino acid sequence at least 50% identical, not including any amino acid insertions at identified insertion sites, to the amino acid sequence selected from the group consisting of SEQ ID NO: 1-52, wherein the polypeptide is a sequence-specific DNA-binding polypeptide, fusion proteins comprising such polypeptides, nucleic acids encoding such polypeptides and fusion proteins, and expression vectors and host cells comprising such nucleic acids.

Abstract: A system for a vehicle includes a first closure panel of the vehicle operable between open and closed positions, a second closure panel of the vehicle operable between open and closed positions, at least one sensor that is coupled to the first closure panel and that detects precipitation, and a controller that prompts movement of the first closure panel from a first open position to a second open position based on the detected precipitation.

Abstract: Electrochromic gels that include 20 to 99 wt. % of a polar solvent, 0.5 to 25 wt. % of a rheology modifying agent, and 0.5 to 20 wt. % of an electrochromic material. The rheology modifying agent is soluble in the polar solvent and forms a gel at ambient conditions when dissolved.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: Known jaw movement tracking systems generally allow for a limited tracking of the jaw movement. e.g. they are only able to track the jaw movement in two dimensions or track muscle activations without specifying direction of movements, and are thus unable to fully track the complex jaw movements. The reduced tracking ability of known devices reduces the ability to discriminate between different jaw movements based on the tracked movement. A need exists for a jaw movement tracking system that allows jaw movement tracking for discriminating between different jaw movements. The invention relates to a jaw movement tracking system. invention further relates to a method for use of the jaw movement tracking system.

Abstract: A display element (1) intended to be fitted to a timepiece, including a body (2) provided with a portion (4) including an assembly area (5) configured to receive an insert (3) by embedding, the embeddable insert (3) being provided with a shaft hole (13) configured to adjust the display element (1) on a drive shaft, the body (2) including a portion (4) made of a material having the property of softening, in which the insert (3) is embedded by melting, the insert (3) including a peripheral wall (6) provided with a patterned outer surface (7a) for connection with the portion (4) of the body (2) of the display element (1), the outer surface (7a) being configured to ensure mechanical anchoring of the insert (3) in the portion (4), the peripheral wall (6) projecting, on either side respectively, from opposite faces of the portion (4) of the body (2).

Abstract: A system (1) for attaching a display element (2) to a drive shaft (3) fitted to an analogue display mechanism of a measuring apparatus, the system (1) including a portion (6) for mounting the display element (2) made of a material that has the property of softening and an embeddable end piece (4a) of said drive shaft (3) configured to be incorporated into said portion (4a) by melting, said end piece (4a) including part of a peripheral wall (13) of the drive shaft (3) provided with a patterned outer bonding surface configured to mechanically anchor said end piece (4a) in said portion (6).

Abstract: The invention relates to a bruxism detection and feedback system comprising an in-ear device having an in-ear portion and a feedback device. The in-ear device comprises a heart rate sensor and/or a breathing rate sensor and a bruxism sensor. The bruxism detection and feedback device further comprises a processor connected to the heart rate sensor and/or the breathing rate sensor, the bruxism sensor and the feedback device. In embodiments the bruxism sensor is an acoustic sensor for measuring an acoustic signal in the ear canal of a wearer. The invention further relates to a method for use of the bruxism detection and feedback system.

Abstract: In various embodiments, a generative design application generates and evaluates automotive designs. In operation, the generative design application computes a first set of metric values based on a set of metrics associated with design goal(s) and a first set of parameter values for a parameterized automobile model. The generative design application then performs optimization operation(s) on the first set of parameter values based on the first set of metric values to generate a second set of parameter values. Subsequently, the generative design application generates at least one design based on the second set of parameter values that is more convergent with respect to at least one of the design goals than a previously generated design. Advantageously, less time and effort are required to generate and evaluate multiple designs and then optimize those designs relative to more manual prior art approaches.

Abstract: A urinary catheter package with a case having a hollow tube which is closed at one end and open at the other end, the hollow tube having a wall and a pierceable cover attached to the open end of the hollow tube. Also an assembly including the urinary catheter package and a catheter with a funnel at a first end.

Abstract: A computer-implemented method for obtaining actionable application feedback includes executing an application on remote computing systems and, during execution of the application on each computing system: surfacing a UI including a survey UI element on the display of the computing system; surfacing a first survey prompt via the survey UI element; receiving user input including a response to the first survey prompt, inputting the user input to an LLM; generating, via the LLM, a second survey prompt based on the provided user input; surfacing the second survey prompt via the survey UI element; receiving user input including a verbatim response to the second survey prompt; and generating, via the LLM, topic tag(s) corresponding to the verbatim response. The method includes aggregating the verbatim responses received via the computing systems according to the corresponding topic tag(s), as well as generating, via the LLM, application insights based on the aggregated verbatim responses.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria and design objectives associated with the urban design project and then generates numerous candidate designs that meet the design criteria and optimize the design objectives to varying degrees. The evaluation engine evaluates each candidate design to generate a set of metrics. The geometry engine modifies the candidate designs based on corresponding metrics to generate candidate designs that better meet the design criteria and more effectively achieve the design objectives.

Abstract: An urban design pipeline is configured to automatically generate design options that meet competing design objectives. A geometry engine within the urban design pipeline generates candidate designs for an urban design project. An evaluation engine within the urban design pipeline evaluates the degree to which each candidate design addresses the competing design objectives to produce a set of design metrics. A tradeoff engine within the urban design pipeline generates a design tradeoff space based on the candidate designs and corresponding design metrics. The tradeoff engine traverses the design tradeoff space based on performance modifications to adjust the degree to which the competing design objectives are addressed. The performance modifications can be obtained from any number of stakeholders in the urban design project.

Abstract: A design engine is configured to automatically generate designs for multi-family housing projects that simultaneously meet local construction regulations while also meeting specific financial targets. The design engine includes a design analyzer that generates design trends based on a database of historical designs. A feature extractor within the design analyzer performs a geometrical analysis of the historical designs to generate a library of features. A feature parameterizer within the design analyzer performs a parameterization process to generate one or more parametric values for each feature. A parameter correlator within the design analyzer compares different subsets of parametric values to identify relationships between those values. A trend aggregator identifies relationships that occur across multiple historical designs to determine a set of design trends. The design engine generates design options using the design trends.

Abstract: A safety signaling system comprises a panel including an HMI for setting first operator safety condition to one of VOTE and NO VOTE, a first optical transceiver for connection to a first optical fiber and a second optical transceiver for connection to a second optical fiber. Panel control circuitry connected between HMI and first transceiver activates first transceiver to transmit continuous wave (CW) light signal into first optical fiber only while HMI sets first operator safety condition to VOTE. A remote interface includes a third optical transceiver for connection to first optical fiber, a fourth optical transceiver for connection to second optical fiber, and remote interface control circuitry connected to third transceiver.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: An urban design pipeline automatically generates design options for an urban design project. The urban design pipeline includes a geometry engine and an evaluation engine. The geometry engine analyzes design criteria, design objectives, and design heuristics associated with the urban design project and then generates numerous candidate designs. The design criteria specify a property boundary associated with a region of land to be developed. The design objectives indicate a specific type of topology that is derived from an existing urban layout. The design heuristics include different sets of construction rules for generating designs with specific types of topologies. The geometry engine generates candidate designs that conform to the property boundary and have topological characteristics in common with the existing urban layout.

Abstract: A method and system for generating synthetic privacy preserving training data for training a language classifier machine-learning (ML) model includes receiving a request to generate the synthetic privacy-preserving training data for the language classifier ML model, retrieving labeled training data associated with training the language classifier ML model, providing the labeled training data, one or more privacy parameters, and a domain type associated with the labeled training data to a synthetic data generation ML model, the synthetic data generation ML model being configured to generate synthetic training data in a privacy-persevering manner, receiving synthetic privacy-preserving training data as an output from the synthetic data generation ML model, and providing the synthetic privacy preserving training data to the language classifier ML model for training the language classifier ML model in classifying text.