Abstract: A workflow engine processes a work problem to generate solutions for the work problem comprising a plurality of related optimization problems. The work problem may comprise a second optimization problem that is dependent on a first optimization problem, such that at least one solution for the first optimization problem is to be utilized as an initial solution for the second optimization problem. The workflow engine generates and stores a branch object for each optimization problem, each branch object specifying a solver engine assigned for processing the optimization problem and dependency information indicating a dependency relationship between the optimization problem and another optimization problem. The workflow engine processes the work problem based on the branch objects by initiating each solver engine to perform optimization operations on the assigned optimization problem based on the corresponding branch object to generate one or more solutions for the assigned optimization problem.

Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide an updated insulin-to-carbohydrate ratio and an updated total daily insulin. The described processes may be used for periodic updating of the insulin-to-carbohydrate ratio and the total daily insulin. The insulin-to-carbohydrate ratio and/or the total may be used in the calculation of new doses of insulin that a drug delivery device may be commanded to deliver to a user.

Abstract: An attachment for a haircare appliance, the attachment including an air inlet, an air outlet, a hollow body defining a flow path between the air inlet and the air outlet, and a curved surface adjacent to and downstream of the air outlet, the curved surface extending outwardly from the hollow. A haircare appliance having an air inlet, an air outlet, and an airflow generator for generating an airflow from the air outlet to the air outlet. The haircare appliance has a hollow body defining a flow path between the air inlet and the air outlet, and a curved surface adjacent to and downstream of the air outlet. The curved surface extends outwardly from the hollow body.

Abstract: A high energy laser (HEL) weapon system for counter-UAS (C-UAS) use comprises a fully self-contained laser system including a power supply, thermal management, high-capacity batteries, and integrated radar and electronic warfare subsystems.

Abstract: A therapeutic agent delivery system includes a catheter, a vascular occluder, a pressure sensor system, and a pump system. The vascular occluder is provided at the distal end of the catheter. The pressure sensor system is provided to sense pressure at the distal end of a catheter lumen, and provides feedback to the pump system. The pump system is adapted to control the rate of infusion of the therapeutic agent through the lumen of the catheter based on the pressure sensed by the pressure sensor system. A method includes deploying the occluder in a vessel, and then sensing a pressure in the vessel. The therapeutic agent is infused into the vessel at a flow rate based on the sensed pressure.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: Churn-aware training of a classifier which reduces the difference between predictions of two different models, such as a prior generation of a classification model and a subsequent generation. A second dataset of labelled data is scored on a prior generation of a classification model, wherein the prior generation was trained on a first dataset of labelled data. A subsequent generation of a classification model is trained with the second dataset of labelled data, wherein in training of the subsequent generation, weighting of at least some of the labelled data in the second dataset, such as labelled data threat yielded an incorrect classification, is adjusted based on the score of such labelled data in the prior generation.

Abstract: A haircare appliance having an air inlet, an air outlet, and an airflow generator for generating an airflow from the air inlet to the air outlet and an attachment for a haircare appliance, the attachment including an air inlet, an air outlet. A curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment has a curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment is configured such that airflow exiting the air outlet generates a first force to attract hair toward the curved surface, and a second force to push hair away from the curved surface.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: The current invention relates to a method of separating polyunsaturated fatty acids containing lipids from a lipids containing biomass.

Abstract: There is provided a fan assembly comprising a motor-driven impeller arranged to generate an airflow, an air outlet arranged to emit the airflow, a plurality of sensors arranged to measure a value for each of a plurality of air quality characteristics, a display and a processor. The processor is configured to receive measured values for each of the plurality of air quality characteristics, identify one of a corresponding set of intervals within which the measured value falls and select an air quality index value associated with the identified interval. The processor is then configured to identify the highest of the selected air quality index values as a current overall air quality index value and to cause the display to display a time series plot of the current air quality index value and a number of preceding air quality index values.

Abstract: A haircare appliance having an air inlet, an air outlet, and an airflow generator for generating an airflow from the air inlet to the air outlet and an attachment for a haircare appliance, the attachment including an air inlet, an air outlet. A curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment has a curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment is configured such that airflow exiting the air outlet generates a first force to attract hair toward the curved surface, and a second force to push hair away from the curved surface.

Abstract: A method for identifying framework regions and complementarity-determining regions in an amino acid sequence. The amino acid sequence is received. A plurality of candidate start positions is identified within the amino acid sequence for a start position for a selected region of interest. A score is generated for each candidate start position of the plurality of candidate start positions via analysis of a motif window that begins at each candidate start position. The start position for the selected region of interest is identified based on a candidate start position of the plurality of candidate start positions having a highest score.

Abstract: A mechanical trigger device comprises a reset screw configured to re-assemble the mechanical trigger device. The resettable screw may be disposed in a slot in a housing of the mechanical trigger device and coupled to a firing pin disposed within the housing. The reset screw may be configured to translate the firing pin within the housing and re-engage a sear after use of the mechanical trigger device.

Abstract: A haircare appliance having an air inlet, an air outlet, and an airflow generator for generating an airflow from the air inlet to the air outlet and an attachment for a haircare appliance, the attachment including an air inlet, an air outlet. A curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment has a curved surface adjacent to and downstream of the air outlet. The haircare appliance or the attachment is configured such that airflow exiting the air outlet generates a first force to attract hair toward the curved surface, and a second force to push hair away from the curved surface.

Abstract: This invention in one aspect relates to an iron-based foam usable for an electrochemical device, comprising a composition comprising iron and a refractory element processed to form the iron-based foam having a hierarchical porous structure with self-assembled channels for gas flow reactions and internal space to accommodate volumetric changes on oxidation.

Abstract: An attachment for a haircare appliance, the attachment including an air inlet, an air outlet for emitting the airflow. The attachment has a curved surface adjacent to and downstream of the air outlet, and a flat surface adjacent to and extending rearwardly from the air outlet. A haircare appliance having an air inlet, an air outlet, and an airflow generator for generating an airflow from the air inlet to the air outlet. The haircare appliance has a curved surface adjacent to and downstream of the air outlet, and a flat surface adjacent to and extending rearwardly from the air outlet.

Abstract: Systems, methods and apparatus are disclosed for improving medical procedures and medical procedure management, and, more particularly, for tracking medical instruments throughout a procedure and assisting medical personnel throughout the procedure or at least at the conclusion of the procedure. In one form, an apparatus for tracking medical instruments throughout a procedure is disclosed having a single camera for tracking movement and/or detecting position of a plurality of medical instruments during a medical procedure as at least one of the plurality of medical instruments is moved between multiple zones at least including a first prep zone and a second procedure zone. The apparatus having a controller connected to and collecting images from the camera, and a display in electrical communication with the controller and/or the camera for displaying medical instrument data pertaining to the movement and/or position of the plurality of medical instruments.

Abstract: Participants as requestors using a requesting network element request one or more tokenization processors to generate tokens that represent a sanitized version of data such that the resultant tokens are amenable to comparison across participants. As circumstances warrant, one or more such tokens can be submitted to the tokenization processor(s) to privately retrieve the original data. Role-based access control scope parameters and tokenization processor-specific tokenization processor secrets can be embedded into reversible tokens that remain invariant under updating of the tokenization processor secrets across tokenization processors.