Abstract: In various embodiments, a computer-implemented method for generating a multi-objective model shared between multiple participants comprises receiving a first input associated with a first selectable component in a set of pre-defined selectable components associated with a shared design model, where the first selectable component is a first component type that is associated with a first persona in a plurality of personas, and each persona includes a distinct set of design goals that the shared design model represents in a multi-objective design problem, in response to the first input, modifying the shared design model to generate a modified shared design model that includes the first selectable component, and generating, based on the modified shared design model, a set of candidate design solutions that satisfy the distinct sets of design goals, where each candidate design solution includes additional selectable components of a second component type.

Abstract: A voxel-based design approach enables the creating and modifying of a design model comprising a 3D grid of discrete voxels that is represented by a voxel data structure. The voxel data structure comprises voxel-level entries, each entry corresponding to a voxel based on the 3D location within the 3D grid. The voxel data structure includes a design-level entry for storing design-level performance metrics. The system updates the voxel data structure to reflect user modifications to the design model and renders a visualization of the updated design model. The system displays a per-voxel heat map for the design model for a selected performance metric based on the voxel data structure. The design system displays multiple optimized design solutions based on corresponding optimized voxel data structures. The system generates the multiple optimized design solutions based on a voxel-based optimization technique. The system also performs a voxel-based recommendation visualization technique.

Abstract: A voxel-based design approach enables the creating and modifying of a design model comprising a 3D grid of discrete voxels that is represented by a voxel data structure. The voxel data structure comprises voxel-level entries, each entry corresponding to a voxel based on the 3D location within the 3D grid. The voxel data structure includes a design-level entry for storing design-level performance metrics. The system updates the voxel data structure to reflect user modifications to the design model and renders a visualization of the updated design model. The system displays a per-voxel heat map for the design model for a selected performance metric based on the voxel data structure. The design system displays multiple optimized design solutions based on corresponding optimized voxel data structures. The system generates the multiple optimized design solutions based on a voxel-based optimization technique. The system also performs a voxel-based recommendation visualization technique.

Abstract: In various embodiments, a computer-implemented method comprises receiving, during a real-time collaboration session, a first input associated with a first selectable component, where the first selectable component is included in a set of pre-defined selectable components associated with a shared design model, and the first selectable component is a first component type that includes a first set of characteristics, in response to receiving a confirmation of the first input, modifying the shared design model to generate a modified shared design model, where the modified shared design model includes the first selectable component, computing, based on the modified shared design model, a set of metrics including a first behavioral metric, computing, based on the set of metrics, a first collaboration score for a first participant and at least one other participant, and displaying a design space that includes the modified shared design model and the first collaboration score.

Abstract: A design engine is configured to interact with potential occupants of a structure in order to generate data that defines the usage preferences of those occupants. The design engine generates multiple candidate designs for the structure via a generative design process, and then evaluates each candidate design using a set of metrics determined relative to the usage preferences. Based on these evaluations, the design engine selects at least one candidate design that optimizes the set of metrics across all potential occupants.

Abstract: This disclosure relates to technology for embedding machine-readable labels (“MRLs”) into digital media files. Digital media files may be presented on different screen sizes, having different resolutions, different frame refresh rates and other display properties. Each screen may therefore present an MRL differently, potentially negatively impacting scan-ability of the presented MRL. Systems disclosed herein receive a set of design choices for an MRL. The systems may resize pre-existing content in one or more video frames of the media file and create a space within each video frame for displaying the MRL. The systems may render a resultant video file for a target screen size that includes a reliably scannable MRL embedded in the video frame(s).

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas13b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.

Abstract: Presented herein are techniques to facilitate dynamic virtual background image selection for a video collaboration session. In one example, a method may include storing each of a plurality of virtual background images for a first user of a video collaboration system in association with one or more keywords; and upon initiation of a video collaboration session for the first user, automatically providing a first virtual background image for the first user based, at least in part, on at least one of, a first context keyword for the session matching at least one keyword stored in association with the first image or scheduling information associated with the session. In one instance, the method automatically providing a second virtual background image for the first user based on a second context keyword obtained from a transcript of the session that matches at least one keyword stored in association with the second image.

Abstract: A design analysis engine analyzes a CAD assembly to generate a topological model. The topological model is a graph of nodes coupled together via a set of edges. Each node represents a different CAD model in the CAD assembly and each edge represents a different connection between two such CAD models. The design analysis engine also analyzes the CAD assembly to generate a data model corresponding to the topological model. The data model is a structured dataset that includes component entries and connection entries. A component entry includes design data associated with a CAD model in the CAD assembly and a connection entry includes design data associated with a physical or logical connection between two or more such CAD models. A user interacts with the topological model to navigate the CAD assembly, obtain CAD model data, and initiate automatically-performed design tasks.

Abstract: The present disclosure provides compositions of microparticles and uses thereof for removing toxic or undesirable molecules from an environment, e.g. the blood of a subject. The microparticles can be liposomes. In one embodiment, the aqueous phase of the liposomes contains (i) a system of generating NAD+ from NADH, and (ii) one or more enzymes that are involved in one or more NAD+-dependent reactions that remove the toxic or undesirable molecules from the environment. In one embodiment, the liposomes contain NADH oxidase, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) to remove ethanol from the blood of a subject.

Abstract: This disclosure relates to technology for embedding machine-readable labels (“MRLs”) into digital media files. Digital media files may be presented on different screen sizes, having different resolutions, different frame refresh rates and other display properties. Each screen may therefore present an MRL differently, potentially negatively impacting scan-ability of the presented MRL. Systems disclosed herein receive a set of design choices for an MRL. The systems may resize pre-existing content in one or more video frames of the media file and create a space within each video frame for displaying the MRL. The systems may render a resultant video file for a target screen size that includes a reliably scannable MRL embedded in the video frame(s).

Abstract: In various implementations, a productivity application allows selected content from an electronic document to be shared with and edited by multiple users through instances of a collaboration component. The collaboration component includes a distributed data structure that stores state information about the shared content. The component also includes application logic for managing the state information to reflect user edits and other such changes. This allows the selected content to be shared with the users in any application that supports the collaboration component and without the entirety of the document having to be shared. A user can experience the content in the context of applications other than the productivity application that hosts the document.

Abstract: The disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

Abstract: Embodiments of the present invention provide for an optimized tissue homogenization buffer composition and a method of using an optimized tissue homogenization buffer for efficient quantitation of a therapeutic oligonucleotide in multiple tissues. The exemplary method comprising: mixing the tissue with a homogenization buffer composition to create a tissue homogenate; adding the tissue homogenate to a quantity of oligonucleotide-free plasma to create a tissue homogenate solution; adding a quantity of a reference standard oligonucleotide to the tissue homogenate solution to create a homogenate/plasma/standard solution; adding a quantity of a phenol/chloroform/isoamyl alcohol to the homogenate/plasma/standard solution; employing centrifugal force to separate a supernatant from the homogenate/plasma/standard solution; and analyzing the supernatant for a concentration of the oligonucleotide.

Abstract: A computer-implemented method for computationally determining ventilation efficiency when generating a building design comprises: generating a first three-dimensional (3D) mesh based on a first 3D building model; performing a first fluid dynamic computer simulation based on the first 3D mesh and first environmental data associated with the first 3D building model to generate a first output data set; and computing, based on the first output data set, a first value for a ventilation performance metric that is associated with the first 3D building model.

Abstract: A UI for presenting and reviewing a document is optimized based upon the type of computing device being utilized to present the document. One such UI includes a first pane showing a view of the document under review that is sized and formatted for display on a large-format display device. The first pane can also be utilized to emphasize a portion of the document. The UI also includes a second pane that includes indicators for each of the reviewers of the document. The selection of an indicator will cause a portion of the document being reviewed by the corresponding reviewer to be displayed in the first pane. The UI also includes a third pane that includes a scaled image of the document shown in the first pane. Selection of a portion of the scaled image causes the selected portion of the document to be displayed in the first pane.

Abstract: The presently described compounds relate to the treatment of Type I and/or Type II diabetes and/or hyperglycemia. More particularly, the described compounds relate to extended time action acylated insulin compounds that lower blood glucose, pharmaceutical compositions containing such compounds, therapeutic uses of such compounds, and an intermediate compound used to make the acylated insulin compounds.

Abstract: Calibration imaging tips and related methods of use are described. In some embodiments, a calibration imaging tip may be positioned on a distal end portion of an imaging device to place a calibration surface within a predetermined distance of a focal plane of the imaging device. The imaging device may then be calibrated using one or more images of the calibration surface.

Abstract: A method and system for generating synthetic privacy preserving training data for training a language classifier machine-learning (ML) model includes receiving a request to generate the synthetic privacy-preserving training data for the language classifier ML model, retrieving labeled training data associated with training the language classifier ML model, providing the labeled training data, one or more privacy parameters, and a domain type associated with the labeled training data to a synthetic data generation ML model, the synthetic data generation ML model being configured to generate synthetic training data in a privacy-persevering manner, receiving synthetic privacy-preserving training data as an output from the synthetic data generation ML model, and providing the synthetic privacy preserving training data to the language classifier ML model for training the language classifier ML model in classifying text.

Abstract: Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed. A barrier for an imaging device may include an optically transparent window configured to be removably attached to a distal portion of the imaging device. The barrier may also include a flexible barrier secured to the optically transparent window configured to cover portions of the imaging device located proximal relative to the optically transparent window. The barrier may include a second flexible barrier secured to the optically transparent window and disposed over at least a portion of the first flexible barrier.