Abstract: Embodiments related to sterilizable handheld medical imaging devices including a rigid imaging tip, a sealed housing, and/or a sealed cable assembly as well as their methods of use and manufacture are described.

Abstract: A computer-implemented method for space frame design involves constructing a load stress map in a geometrical boundary representation of a design space, defining attachment points and load application points in the design space, creating a starting network of interconnecting lines between each two of the attachment points and load application points in the design space, assigning load application factors to each line of the starting network of interconnecting lines based on values of the load stress map, generating potential space frame designs by culling different subsets of lines of the starting network of interconnecting lines for each potential space frame design according to variable culling parameters, evaluating the potential space frame designs with respect to optimization parameters, combining the culling parameters for the potential space frame designs the performance score of which is above a predefined performance threshold, and iterating the steps of generating potential space frame designs and e

Abstract: A drain cover and drain cover system are disclosed. The drain cover includes a flange portion that rests on a bottom of a body designed for use with running water, such as a bathtub or shower. The drain cover overlays a drain on the body to prevent water from going down the drain until the water exceeds a predetermined height in the body. Further, the drain cover does not require fasteners to maintain it in place, instead relying upon hydrostatic pressure applied to the drain cover by the water and friction between the drain cover and the body.

Abstract: The disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

Abstract: A package for a medical device such as an intermittent catheter has a case which is closed at one end and open at the other end. A cap is connected to the case by a hinge to permit selectable movement of the cap between an open position, wherein access is provided to the open end of the case, and a closed position, wherein the cap prevents access to the open end of the case. A seal is connected to one of the cap and case. The seal is engageable with the other of the cap and case when the cap is closed to form a barrier that maintains a sterile environment inside the package. The seal can be repeatedly made and broken whenever the user closes or opens the cap, respectively. One of the case and cap has a latch and the other has a receptacle for receiving the latch to releasably retain the cap in a closed position. The latches fit into the receptacle to prevent lateral forces from distorting the cap when the cap is closed. A locking slide may be used to lock the cap to the case.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for training machine learning models. One method includes obtaining a machine learning model, wherein the machine learning model comprises one or more model parameters, and the machine learning model is trained using gradient descent techniques to optimize an objective function; determining an update rule for the model parameters using a recurrent neural network (RNN); and applying a determined update rule for a final time step in a sequence of multiple time steps to the model parameters.

Abstract: A computer-implemented method for computationally determining ventilation efficiency when generating a building design comprises: generating a first three-dimensional (3D) mesh based on a first 3D building model; performing a first fluid dynamic computer simulation based on the first 3D mesh and first environmental data associated with the first 3D building model to generate a first output data set; and computing, based on the first output data set, a first value for a ventilation performance metric that is associated with the first 3D building model.

Abstract: Methods and systems for performing black box optimization to identify an output that optimizes an objective.

Abstract: Technologies for unseen notification handling are described. Embodiments select an initial set of notifications, provide the selected initial set of notifications to a client device, store seen notifications in a first data store, maintain sent but unseen notifications in a second data store that is an in-memory online data store, retrieve a set of the sent but unseen notifications from the second data store, create a list of unseen notifications by combining the retrieved set of sent but unseen notifications with a set of unsent and unseen notifications, generate a set of relevance scores for the list of unseen notifications, create a new version of the list of unseen notifications based on the new set of relevance scores, and provide the new version of the list of the unseen notifications to the client device.

Abstract: A method for grouping immune cells within an immune cell receptor sequence dataset, is disclosed. An immune cell receptor sequence dataset is obtained from a sample. The dataset includes a plurality of full-length immune cell receptor sequences. Each full-length immune cell receptor sequence can comprise of at least one heavy chain region sequence and one light chain region sequence. Each immune cell receptor sequence is associated with an individual immune cell in the sample. The immune cell receptor sequences associated with a first immune cell and a second immune cell from the sample is compared using a comparison protocol. The first immune cell and the second immune cell are identified as members of the same clonotype if one or more immune cell receptor sequence comparison criteria is met.

Abstract: A design application is configured to generate a latent space representation of a fleet of pre-existing vehicles. The design application encodes vehicle designs associated with the fleet of pre-existing vehicles into the latent space representation to generate a first latent space location. The first latent space location represents the characteristic style associated with the fleet of pre-existing vehicles. The design application encodes a sample design provided by a user into the latent space representation to produce a second latent space location. The design application then determines a distance between the first latent space location and the second latent space location. Based on the distance, the design application generates a style metric that indicates the aesthetic similarity between the sample design and the vehicle designs associated with the fleet of pre-existing vehicles. The design application can also generate new vehicle designs based on the latent space representation and the sample design.

Abstract: In various embodiments, a generative design application generates and evaluates automotive designs. In operation, the generative design application computes a first set of metric values based on a set of metrics associated with design goal(s) and a first set of parameter values for a parameterized automobile model. The generative design application then performs optimization operation(s) on the first set of parameter values based on the first set of metric values to generate a second set of parameter values. Subsequently, the generative design application generates at least one design based on the second set of parameter values that is more convergent with respect to at least one of the design goals than a previously generated design. Advantageously, less time and effort are required to generate and evaluate multiple designs and then optimize those designs relative to more manual prior art approaches.

Abstract: Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: Churn-aware training of a classifier which reduces the difference between predictions of two different models, such as a prior generation of a classification model and a subsequent generation. A second dataset of labelled data is scored on a prior generation of a classification model, wherein the prior generation was trained on a first dataset of labelled data. A subsequent generation of a classification model is trained with the second dataset of labelled data, wherein in training of the subsequent generation, weighting of at least some of the labelled data in the second dataset, such as labelled data threat yielded an incorrect classification, is adjusted based on the score of such labelled data in the prior generation.

Abstract: A method is provided for manufacturing a polymer-coated elastic braid including forming a plurality of elastic filaments into a braid. The braid is mounted within a tubular mandrel. The mandrel-mounted braid is dip-coating in a polymer solution containing a polymer and at least one solvent. The dip-coated braid is then heated to release the at least one solvent. Then, the dip-coated mandrel-mounted braid is cooled to solidify the polymer on the braid. The braid is then removed from the mandrel. The braid can be attached to a catheter for use as a microvalve in a vessel.

Abstract: Various embodiments include methods and apparatus structured to install an optical fiber cable into a well at a well site. In a from-bottom-to-top embodiment, an anchor deployed at a selected location in a hole of the well can be used and the optical fiber cable can be pulled up to a surface of the well from the selected location. In a from-top-to-bottom embodiment, an optical fiber cable can be moved down from the surface until an end of the optical fiber cable is locked at a selected location by a catcher disposed at the selected location. With the optical fiber cable in the well, a portion of the optical fiber cable can be coupled to surface instrumentation. Additional apparatus, systems, and methods can be implemented in a variety of applications.

Abstract: A pipe isolation device and method of using the same. The pipe isolation device includes a control bar head, a first sealing head, and a second sealing head. The first sealing head has a first seal element and a first sliding engagement. The first sliding engagement permits the first sealing head to slide relative to the control bar head along a first fixed path and traverse a right angle to gain access to an interior space of a pipe. The second sealing head has a second seal element and a second sliding engagement. The second sliding engagement permits the second sliding head to slide relative to the first sealing head along a second fixed path and traverse the right angle to gain access to an interior space of the pipe. A first seal element and a second seal element are disposed on the sealing heads and have axially-offset configurations.

Abstract: In various implementations, a productivity application allows selected content from an electronic document to be shared with and edited by multiple users through instances of a collaboration component. The collaboration component includes a distributed data structure that stores state information about the shared content. The component also includes application logic for managing the state information to reflect user edits and other such changes. This allows the selected content to be shared with the users in any application that supports the collaboration component and without the entirety of the document having to be shared. A user can experience the content in the context of applications other than the productivity application that hosts the document.

Abstract: A design engine is configured to interact with potential occupants of a structure in order to generate data that defines the usage preferences of those occupants. The design engine generates multiple candidate designs for the structure via a generative design process, and then evaluates each candidate design using a set of metrics determined relative to the usage preferences. Based on these evaluations, the design engine selects at least one candidate design that optimizes the set of metrics across all potential occupants.