Abstract: A therapeutic agent delivery system includes a catheter, a vascular occluder, a pressure sensor system, and a pump system. The vascular occluder is provided at a distal end of the catheter. The pressure sensor system is provided to sense pressure at a distal end of a catheter lumen, and provides feedback to the pump system. The pump system is adapted to control a rate of infusion of a therapeutic agent through the catheter lumen based on the pressure sensed by the pressure sensor system. A method includes deploying the vascular occluder in a vessel, and then sensing a pressure in the vessel. The therapeutic agent is infused into the vessel at a flow rate based on the sensed pressure in the vessel.

Abstract: A package for a medical device such as an intermittent catheter has a case which is closed at one end and open at the other end. A cap is connected to the case by a hinge to permit selectable movement of the cap between an open position, wherein access is provided to the open end of the case, and a closed position, wherein the cap prevents access to the open end of the case. A seal is connected to one of the cap and case. The seal is engageable with the other of the cap and case when the cap is closed to form a barrier that maintains a sterile environment inside the package. The seal can be repeatedly made and broken whenever the user closes or opens the cap, respectively. One of the case and cap has a latch and the other has a receptacle for receiving the latch to releasably retain the cap in a closed position. The latches fit into the receptacle to prevent lateral forces from distorting the cap when the cap is closed. A locking slide may be used to lock the cap to the case.

Abstract: A technique which facilitates cleaning of an interior of a pipe via access through a lateral hole in the pipe. The technique utilizes a control bar head coupled with a sweeper system which may be inserted into the pipe through the lateral hole. The sweeper system may comprise a plurality of shiftable sweeper heads which generally align for insertion through the lateral hole and then transition along the interior of the pipe to effectively sweep particles along the interior of the pipe. The sweeper system effectively clears an area of the interior of the pipe to facilitate a more effective seal with a subsequently inserted pipe isolation device.

Abstract: A design application is configured to generate a latent space representation of a fleet of pre-existing vehicles. The design application encodes vehicle designs associated with the fleet of pre-existing vehicles into the latent space representation to generate a first latent space location. The first latent space location represents the characteristic style associated with the fleet of pre-existing vehicles. The design application encodes a sample design provided by a user into the latent space representation to produce a second latent space location. The design application then determines a distance between the first latent space location and the second latent space location. Based on the distance, the design application generates a style metric that indicates the aesthetic similarity between the sample design and the vehicle designs associated with the fleet of pre-existing vehicles. The design application can also generate new vehicle designs based on the latent space representation and the sample design.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: A technique is provided for isolating a pipe during maintenance or servicing of the pipe. The technique may utilize a control bar head having a coupling feature for coupling with a control bar. The control bar head also has a bleed passage extending therethrough to the coupling feature and thus to the control bar when engaged with the control bar. Additionally, the system may comprise a first sealing head slidably engaged with the control bar head. The first sealing head may comprise a first seal element and a first sealing head bleed passage extending therethrough to the control bar head. The system also may comprise a second sealing head slidably engaged with the first sealing head and having a second seal element. The first sealing head bleed passage may be arranged to extend to a region between the first sealing head and the second sealing head to facilitate bleeding of this region.

Abstract: Various embodiments include methods and apparatus structured to install an optical fiber cable into a well at a well site. In a from-bottom-to-top embodiment, an anchor deployed at a selected location in a hole of the well can be used and the optical fiber cable can be pulled up to a surface of the well from the selected location. In a from-top-to-bottom embodiment, an optical fiber cable can be moved down from the surface until an end of the optical fiber cable is locked at a selected location by a catcher disposed at the selected location. With the optical fiber cable in the well, a portion of the optical fiber cable can be coupled to surface instrumentation. Additional apparatus, systems, and methods can be implemented in a variety of applications.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for training machine learning models. One method includes obtaining a machine learning model, wherein the machine learning model comprises one or more model parameters, and the machine learning model is trained using gradient descent techniques to optimize an objective function; determining an update rule for the model parameters using a recurrent neural network (RNN); and applying a determined update rule for a final time step in a sequence of multiple time steps to the model parameters.

Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the pancreas using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating pancreatic cancer comprising administering TLR agonists to the pancreas.

Abstract: Various embodiments set forth systems and techniques for determining expandability of a budding design. The techniques include receiving a building geometry indicating a size of a building and a shape of the building; receiving building placement data indicating a placement of the building within a site; identifying one or more remaining spaces within the site based at least on the size of the building, the shape of the building, and the placement of the building within the site; for each remaining space of the one or more remaining spaces: determining whether the remaining space is a usable space; based on the determining whether the remaining space is a usable space, generating a space expansion value corresponding to the remaining space; and computing, based on space expansion values corresponding to the one or more remaining spaces, one or more aggregate expansion values associated with the building geometry and the building placement.

Abstract: A technique which facilitates cleaning of an interior of a pipe via access through a lateral hole in the pipe. The technique utilizes a control bar head which may be coupled with a control bar via a coupling feature. A shroud is positioned around the control bar head. The shroud may have a suitable shape with an interior sized to enable linear movement of the control bar head along the interior between an extended position and a retracted position. Additionally, the shroud has an exterior sized to enable insertion through the lateral hole in the pipe. Magnets may be coupled with the control bar head and oriented to pick up particles in the pipe when the control bar head is located in the extended position. When the control bar head is shifted to the retracted position, the magnets ensure retrieval of the particles into the shroud for removal from the pipe when the system is withdrawn.

Abstract: A method is provided for identifying one or more D gene segment in a VDJ or VDDJ sequence. The method can include obtaining a B cell receptor and/or T cell receptor data set, wherein the data set includes a VDJ sequence, aligning the VDJ sequence to one or more VDJ reference sequences thereby generating a first potential alignment and a second potential alignment, determining a first score for the first potential alignment and a second score for the second potential alignment in accordance with a D gene segment alignment scoring schema, and identifying a D gene segment region associated with a highest score between the first score and the second score.

Abstract: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating metastases of uveal melanoma of the liver comprising administering TLR9 agonists to the liver.

Abstract: The present disclosure provides compositions of microparticles and uses thereof for removing toxic or undesirable molecules from an environment, e.g. the blood of a subject. The microparticles can be liposomes. In one embodiment, the aqueous phase of the liposomes contains (i) a system of generating NAD+ from NADH, and (ii) one or more enzymes that are involved in one or more NAD+-dependent reactions that remove the toxic or undesirable molecules from the environment. In one embodiment, the liposomes contain NADH oxidase, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) to remove ethanol from the blood of a subject.

Abstract: A design simulator executes a rigid body simulation to position design elements within various design options according to configurations that meet design criteria while also promoting feasibility and desirability. The design simulator assigns physical properties to each design element, including a mass value and a velocity value. The design simulator then simulates rigid body interactions between design elements over a sequence of simulation steps. The design simulator stops the rigid body simulation when no collisions between design elements are detected or when other termination criteria are met. Once the rigid body simulation is complete, the final positions of each design element relative to one another represent a specific configuration of design elements for the corresponding design option.

Abstract: In various embodiments, an automobile modeling application generates automobile designs. In operation, the automobile modeling application determines a first parameter value associated with a first instance of a first parameterized automobile component. The automobile modeling application then computes a second parameter value associated with a second instance of a second parameterized automobile component based on a structural relationship between the first instance and the second instance. Subsequently, the automobile modeling application generates a computer-aided design (CAD) geometry model for an automobile based on the first parameter value, the second parameter value, and one or more functional relationships defined between two or more instances included in a set of parameterized automobile component instances.

Abstract: A package for a medical device such as an intermittent catheter has a case which is closed at one end and open at the other end. A cap is connected to the case by a hinge to permit selectable movement of the cap between an open position, wherein access is provided to the open end of the case, and a closed position, wherein the cap prevents access to the open end of the case. A seal is connected to one of the cap and case. The seal is engageable with the other of the cap and case when the cap is closed to form a barrier that maintains a sterile environment inside the package. The seal can be repeatedly made and broken whenever the user closes or opens the cap, respectively. One of the case and cap has a latch and the other has a receptacle for receiving the latch to releasably retain the cap in a closed position. The latches fit into the receptacle to prevent lateral forces from distorting the cap when the cap is closed. A locking slide may be used to lock the cap to the case.

Abstract: Embodiments provided herein measure metrics of an athletic action and an object associated therewith, and more particularly, to measuring the metrics and characteristics of a baseball during the wind-up, release, flight, and catch of a pitch sequence. Methods may include: receiving, from at least one motion sensor associated with an object, acceleration data and angular velocity data of the object in response to an athletic action performed on the object; processing the acceleration data to establish vector rotation data between a frame of reference of the object and an Earth frame of reference; applying the vector rotation data to the acceleration data to obtain acceleration of the object in the Earth frame of reference; applying the vector rotation data to the angular velocity data to obtain angular velocity of the object in the Earth frame of reference.

Abstract: A voxel-based design approach enables the creating and modifying of a design model comprising a 3D grid of discrete voxels that is represented by a voxel data structure. The voxel data structure comprises voxel-level entries, each entry corresponding to a voxel based on the 3D location within the 3D grid. The voxel data structure includes a design-level entry for storing design-level performance metrics. The system updates the voxel data structure to reflect user modifications to the design model and renders a visualization of the updated design model. The system displays a per-voxel heat map for the design model for a selected performance metric based on the voxel data structure. The design system displays multiple optimized design solutions based on corresponding optimized voxel data structures. The system generates the multiple optimized design solutions based on a voxel-based optimization technique. The system also performs a voxel-based recommendation visualization technique.

Abstract: In various embodiments, a computer-implemented method comprises receiving, during a real-time collaboration session including a plurality of participants, a first input associated with a first selectable component from a set of pre-defined selectable components associated with a shared design model, where the first selectable component is associated with a first participant in the plurality of participants, in response to receiving a confirmation of the first input, modifying the shared design model to generate an updated shared design model, wherein the first selectable component in the updated shared design model includes the modified first selectable component, and causing the updated shared design model to be synchronized with at least one other participant in a plurality of participants included in the real-time collaboration session.