Abstract: Coarse location estimation for mobile devices is disclosed for detecting mobile device presence at general locations of interest and switching operating modes and services for one or more location context aware applications. In some implementations, sensor data is received from a plurality of data sources at a location. For each data source, a first probability is estimated that the mobile device is at the location based on sensor data from the data sources. A second probability is estimated that the mobile device is not at the location based on sensor data from the data sources. The first and second estimated probabilities are statistically combined to generate a third estimated probability that the mobile device is at the location.

Abstract: A method for evaluating in vitro the effect of a xenobiotic (e.g., a drug) on drug metabolism in hepatocytes. The kit comprises a first culture of hepatocytes, a portion of in vitro xenobiotic-stimulated biological sample, and instructions for incubating the first culture of hepatocytes with the portion of in vitro xenobiotic-stimulated biological sample, and analyzing the activity, expression, or a combination thereof of a biomarker in the hepatocytes to evaluate the effect of the xenobiotic on drug metabolism in the hepatocytes.

Abstract: The present disclosure provides systems and methods that perform face reconstruction based on an image of a face. In particular, one example system of the present disclosure combines a machine-learned image recognition model with a face modeler that uses a morphable model of a human's facial appearance. The image recognition model can be a deep learning model that generates an embedding in response to receipt of an image (e.g., an uncontrolled image of a face). The example system can further include a small, lightweight, translation model structurally positioned between the image recognition model and the face modeler. The translation model can be a machine-learned model that is trained to receive the embedding generated by the image recognition model and, in response, output a plurality of facial modeling parameter values usable by the face modeler to generate a model of the face.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas13b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.

Abstract: A treatment system includes a dual lumen catheter system. The first lumen is open to systemic circulation. The second lumen is open to a target delivery location. In an embodiment, a pressure-control element is provided that includes an expanded configuration adapted to constrain delivery through the second lumen to the target delivery location. Methods for treating tissues and organs via vascular pathways are provided.

Abstract: A computer-implemented method for space frame design involves constructing a load stress map in a geometrical boundary representation of a design space, defining attachment points and load application points in the design space, creating a starting network of interconnecting lines between each two of the attachment points and load application points in the design space, assigning load application factors to each line of the starting network of interconnecting lines based on values of the load stress map, generating potential space frame designs by culling different subsets of lines of the starting network of interconnecting lines for each potential space frame design according to variable culling parameters, evaluating the potential space frame designs with respect to optimization parameters, combining the culling parameters for the potential space frame designs the performance score of which is above a predefined performance threshold, and iterating the steps of generating potential space frame designs and e

Abstract: An endovascular microvalve device for use in a vessel during a therapy procedure includes a catheter and a filter valve coupled to the catheters. The filter valve is dynamically reconfigurable to automatically block and permit fluid flow through a vessel based on a local fluid pressure conditions about the filter valve. In embodiments, the filter valve has a proximal end fixed to the catheter, and a distal end which may be movable over the catheter. The lumen of the inner catheter delivers a therapeutic agent beyond the valve. The device is used to provide a therapy in which a therapeutic agent is infused into an organ.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: A collapsible ballistic shield which provides a degree of protection against ballistic threats. The shield includes a head plate, an upper torso plate, a lower torso plate, an upper lock-and-release hinge joint, a lower lock-and-release hinge joint, a primary handle, and a strap-mounting fastener. The head plate is positioned opposite to the lower torso plate, across the upper torso plate to outline a shape of a body. The head plate is pivotably attached to the upper torso plate by the upper lock-and-release hinge joint. The lower torso plate is pivotably attached to the upper torso plate by the lower lock-and-release hinge joint. Resultantly, the shield may be collapsed, expanded, and broken down. The primary handle provides a grasping point and is mounted to a rear surface of the upper torso plate. The strap-mounting fastener allows the user to attach the shield to external structures.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: Improved computer efficiency for document navigation is provided. A transparent overlay is automatically applied to an interactive content element to prevent inadvertent interaction with the element during scrolling operations. In some examples, upon determining a user's intent is to navigate a parent document comprising an embedded interactive element, the overlay is applied, and user-interaction with the interactive element is temporarily disabled. Upon determining the user's intent is to interact with the interactive element, the overlay is removed, and user-interaction with the interactive element is enabled. When the overlay is removed, a contextual hint, such as via a user interface control, can be provided to indicate how to continue navigating the parent document.

Abstract: A collaborative authoring application provides an authoring environment in which two or more users can edit a document concurrently. Each user edits a copy of the document, sends updates to a master copy of the document, and receives updates from the master copy of the document. The authoring environment generally inhibits the users from providing conflicting editing instructions to the master copy of the document. For example, each user can generate a content lock about one or more data units within the document. The authoring environment may synchronize content locks automatically and content only at the request of the user.

Abstract: A therapeutic agent delivery system includes a catheter, a vascular occluder, a pressure sensor system, and a pump system. The vascular occluder is provided at the distal end of the catheter. The pressure sensor system is provided to sense pressure at the distal end of a catheter lumen, and provides feedback to the pump system. The pump system is adapted to control the rate of infusion of the therapeutic agent through the lumen of the catheter based on the pressure sensed by the pressure sensor system. A method includes deploying the occluder in a vessel, and then sensing a pressure in the vessel. The therapeutic agent is infused into the vessel at a flow rate based on the sensed pressure.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: Embodiments are disclosed for compressing radio maps of fingerprint-based positioning systems using different compression models. In an embodiment, a method comprises: receiving, by a computing device, access point (AP) data from a plurality of mobile devices operating in a geographic region, the AP data including signal strength measurements of AP signals received at a plurality of reference locations in the geographic region and uncertainty measurements associated with the signal strength measurements; determining a level of accuracy with the first compression model; responsive to the determining, selecting one of the first compression model or a second compression model to compress the AP data, the second compression model being different than the first compression model; compressing the AP data using the selected compression model; and responsive to a request from a mobile device operating in the geographic region, sending a data packet including the compressed AP data to the mobile device.

Abstract: A design engine for designing an object using structural analysis. The design engine generates a lattice structure for the object comprising a plurality of nodes and a plurality of lines connecting the nodes. The lattice structure is optimized to remove one or more lines using structural analysis based on at least one load-related design requirement. Several design options are provided for generating and optimizing the lattice structure. The design engine then generates a 3D model of the object by thickening each line of the lattice structure into a pipe volume. The thickness of each pipe is determined using structural analysis based on the at least one load-related design requirement. The 3D model represents the volume of the object and is exportable to a fabrication device.

Abstract: Techniques and systems for unlocking a first device based on signals transmitted between the first device and a second device are disclosed. A disclosed technique includes receiving, by a first device, at least one wireless signal from a second device; transmitting, by the first device, at least one wireless signal to the second device; determining, by the first device, transit times of the at least one received wireless signal and the at least one transmitted wireless signal; determining, by the first device, one or more range measurements between the first device and the second device based at least in part on the transit times; determining, by the first device, an unlock decision based at least in part on the one or more range measurements; and causing, by at least the first device, the first device to unlock if the unlock decision is positive.

Abstract: A design analysis engine analyzes a CAD assembly to generate a topological model. The topological model is a graph of nodes coupled together via a set of edges. Each node represents a different CAD model in the CAD assembly and each edge represents a different connection between two such CAD models. The design analysis engine also analyzes the CAD assembly to generate a data model corresponding to the topological model. The data model is a structured dataset that includes component entries and connection entries. A component entry includes design data associated with a CAD model in the CAD assembly and a connection entry includes design data associated with a physical or logical connection between two or more such CAD models. A user interacts with the topological model to navigate the CAD assembly, obtain CAD model data, and initiate automatically-performed design tasks.

Abstract: A design application is configured to generate a latent space representation of a fleet of pre-existing vehicles. The design application encodes vehicle designs associated with the fleet of pre-existing vehicles into the latent space representation to generate a first latent space location. The first latent space location represents the characteristic style associated with the fleet of pre-existing vehicles. The design application encodes a sample design provided by a user into the latent space representation to produce a second latent space location. The design application then determines a distance between the first latent space location and the second latent space location. Based on the distance, the design application generates a style metric that indicates the aesthetic similarity between the sample design and the vehicle designs associated with the fleet of pre-existing vehicles. The design application can also generate new vehicle designs based on the latent space representation and the sample design.