Abstract: A method for delivering an immunotherapy agent to a tumor includes advancing the delivery device into a vessel of a patient, and infusing the agent under pressure into the vessel to penetrate the tumor. The delivery device prevents reflux of the agent toward non-treatment sites.

Abstract: A method of delivering a therapeutic agent into a patient vessel with a delivery device is provided. The delivery device includes an infusion lumen through which the agent is delivered, a vessel occluder that can be operated between a collapsed and an expanded configuration, and when in the expanded configuration occludes the vessel, and a pressure sensor shielded from the effects of turbulent flow at an exit of the infusion lumen. The shield pressure sensor is able to accurately sense pressure in the vessel. The sensed pressure is used to determine a dwell time for the vessel occluder in the expanded configuration.

Abstract: The invention relates to a computer-implemented system and method for automatic collection, analysis and reporting of data relating to a cybersecurity threat. The method may comprise the steps of: presenting an interface through which an executable can be configured and automatically generated; transmitting the executable to a client to enable the client to execute the executable on client systems to automatically collect forensic data; receiving from the client an encrypted data package that includes the forensic data; using a forensic toolset to automatically analyze the forensic data; presenting an option to select one or more of at least two types of output reports designed for different types of readers; inputting the analysis files into an automatic report generator to automatically generate the types of output reports selected by the client; and sending the output reports selected by the client to the client.

Abstract: The present disclosure provides compositions of microparticles and uses thereof for removing toxic or undesirable molecules from an environment, e.g. the blood of a subject. The microparticles can be liposomes. In one embodiment, the aqueous phase of the liposomes contains (i) a system of generating NAD+ from NADH, and (ii) one or more enzymes that are involved in one or more NAD+-dependent reactions that remove the toxic or undesirable molecules from the environment. In one embodiment, the liposomes contain NADH oxidase, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) to remove ethanol from the blood of a subject.

Abstract: A system of translatable electro acoustic technology (EAT) modules for deployment along an oil or gas wellbore casing includes: a wireline/slickline optical distributed acoustic sensing (DAS) cable deployed from the surface into the casing and connected to a surface interrogator; a tractor attached to the downhole end of the wireline/slickline optical distributed acoustic sensing (DAS) cable; and one or more EAT sensing modules that can be coupled to or decoupled from the wireline/slickline optical distributed acoustic sensing (DAS) cable at pre-selected locations and can either be coupled to or decoupled from the casing of the wellbore or be allowed to reposition along the wellborn casing, wherein the one or more EAT sensing modules can conduct multiple measurements and communicate the results via the wireline/slickline optical distributed acoustic sensing (DAS) cable to the surface interrogator.

Abstract: A testability method (500) for testing the operation of a thermoelectric element (110) of a thermoelectric watch (100) including the thermoelectric element (110), a power circuit supplied by primary storage elements (101) and secondary storage elements (102) so as to move at least one moveable element (190) or display information on an electro-optical display device. The testability method (500) includes steps of applying a heat source (540) to the thermoelectric element (110) so as to make it possible to electrically charge (550) or recharge (550) the secondary storage elements (102) in order to move at least one moveable element (190) or display information on an electro-optical display device, and thus check the functionality of the thermoelectric element (110).

Abstract: A package 10 for a medical device such as an intermittent catheter has a case 12 which is closed at one end and open at the other end. A cap 14 is connected to the case by a hinge 16 to permit selectable movement of the cap between an open position, wherein access is provided to the open end of the case, and a closed position, wherein the cap prevents access to the open end of the case. A seal 18 is connected to one of the cap and case. The seal is engageable with the other of the cap and case when the cap is closed to form a barrier that maintains a sterile environment inside the package. The seal can be repeatedly made and broken whenever the user closes or opens the cap, respectively.

Abstract: The invention provides a method for increasing the number concentration of molecules of an analyte of interest in real time from a sample gas flow containing the analyte and other molecules; the method comprising: (a) when the analyte molecules of interest in the sample gas flow are non-ionised or are not ionised to a desired extent, exposing the sample gas flow to an ionising entity to bring about formation of ions of the analyte and then passing the sample gas flow through an ion-concentrating chamber; or (b) when the analyte molecules of interest in the sample gas flow are already ionised, passing the sample gas flow through an ion-concentrating chamber without first exposing the sample gas flow to an ionising entity; whereby, in the ion-concentrating chamber, analyte ions and other molecules are subjected to an electric field and a velocity field such that analyte ions are concentrated by the combined effects of the electric field and velocity field into a smaller space; wherein the ion-concentrating c

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network having a plurality of network parameters and being configured to process an input data item to generate a feature representation comprising a values for each of a plurality of features of the input data item.

Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Aspects of the invention in particular relate to Cpf1 mutants having altered PAM specificity.

Abstract: One embodiment sets forth a computer-implemented method for measuring productivity in buildings and workplaces. The method includes receiving workstation data for a plurality of workstations for the building and operation data for a plurality of operations for the building; generating a building layout specifying, for each workstation of the plurality of workstations, a respective location of the workstation; generating, for each operation of the plurality of operations, a respective productivity value based on the workstation data, the operation data, and the locations of the plurality of workstations; and calculating, based on the productivity values of the plurality of operations, one or more overall productivity values associated with the building layout.

Abstract: Various embodiments set forth systems and techniques for assessing sustainability of a building design. The techniques include receiving a building design for a budding and sustainability certification data describing a plurality of sustainability certification systems; selecting one or more particular sustainability certification systems from the plurality of sustainability certification systems; computing a respective sustainability certification value for each sustainability certification system of the one or more particular sustainability certification systems; and performing one or more building design operations based on sustainability certification system values for the one or more particular sustainability certification systems.

Abstract: Various embodiments set forth systems and techniques for determining expandability of a budding design. The techniques include receiving a building geometry indicating a size of a building and a shape of the building; receiving building placement data indicating a placement of the building within a site; identifying one or more remaining spaces within the site based at least on the size of the building, the shape of the building, and the placement of the building within the site; for each remaining space of the one or more remaining spaces: determining whether the remaining space is a usable space; based on the determining whether the remaining space is a usable space, generating a space expansion value corresponding to the remaining space; and computing, based on space expansion values corresponding to the one or more remaining spaces, one or more aggregate expansion values associated with the building geometry and the building placement.

Abstract: A design engine automatically generates designs for multi-family housing projects that simultaneously meet local construction regulations while also meeting specific financial targets. The design engine includes a design analyzer, a site analyzer, a design generator, and a design evaluator. The design analyzer generates design trends based on a historical database of designs. The site analyzer generates design criteria based on relevant construction regulations. The design generator generates design options that reflect the design trends while also adhering to the construction regulations. The design evaluator then analyzes the design options and generates various design metrics. Based on the design metrics, the design generator generates additional design options that better meet the design criteria.

Abstract: A design engine is configured to automatically generate designs for multi-family housing projects that simultaneously meet local construction regulations while also meeting specific financial targets. A design generator within the design engine generates a first generation of design options that reflect historical design trends. A design evaluator within the design engine then generates design metrics that quantify various attributes of the different design options. The design generator identifies a subset of the design options that optimally balance some or all of the various design metrics, and then generates a subsequent generation of design options that includes design features derived from the subset of design options.

Abstract: A design simulator executes a rigid body simulation to position design elements within various design options according to configurations that meet design criteria while also promoting feasibility and desirability. The design simulator assigns physical properties to each design element, including a mass value and a velocity value. The design simulator then simulates rigid body interactions between design elements over a sequence of simulation steps. The design simulator stops the rigid body simulation when no collisions between design elements are detected or when other termination criteria are met. Once the rigid body simulation is complete, the final positions of each design element relative to one another represent a specific configuration of design elements for the corresponding design option.

Abstract: A design engine is configured to automatically generate designs for multi-family housing projects that simultaneously meet local construction regulations while also meeting specific financial targets. The design engine includes a design analyzer that generates design trends based on a database of historical designs. A feature extractor within the design analyzer performs a geometrical analysis of the historical designs to generate a library of features. A feature parameterizer within the design analyzer performs a parameterization process to generate one or more parametric values for each feature. A parameter correlator within the design analyzer compares different subsets of parametric values to identify relationships between those values. A trend aggregator identifies relationships that occur across multiple historical designs to determine a set of design trends. The design engine generates design options using the design trends.

Abstract: A computer-implemented method for generating a building design for a building site having a complex shape comprises: generating a first group of processing areas from a plurality of processing areas associated with the building design and a second group of processing areas from the plurality of processing areas; generating a first building footprint leg that is sized to include the first group of processing areas and a second building footprint leg that is sized to include the second group of processing areas; at a pivot location, joining the first building footprint leg and the second building footprint leg at an aperture angle; performing a numerical simulation to position the first group of processing areas in the first building footprint leg and the second group of processing areas in the second building footprint leg to generate a candidate building design for the building site; and rendering the candidate building design.

Abstract: Various embodiments set forth systems and techniques for generating work condition values for a building layout. The techniques include receiving a building layout specifying, for each workspace of a plurality of workspaces included in the workplace, a respective location of the workspace; selecting one or more work condition elements from a plurality of work condition elements based at least on the plurality of workspaces; for each work condition element of the one or more work condition elements: evaluating the plurality of workspaces based on the work condition element; based on the evaluating the plurality of workspaces, generating an element value corresponding to the work condition element; and computing, based on element values corresponding to the one or more work condition elements, an overall work condition value associated with the building layout.

Abstract: A design simulator executes a shape parameter engine that generates geometry corresponding to parking lots. The shape parameter engine implements a library of shapes, action markers, and construction rules to generate designs for parking lots. Each shape is a geometric the that can populate a design surface. Each action marker signifies an action that can occur at a specific location on the design surface. Each construction rule describes how shapes should be placed on the design surface relative to one or more action markers. The shape parameter generator tiles the design surface using the library of shapes, action markers, and construction rules to generate valid parking lot designs.