Abstract: A system for continuous determination of annulus pressure in subsurface wells comprises one or more electro acoustic technology sensor assemblies permanently installed in each annulus surrounding a subsurface well; and a fiber optic cable in close proximity to the electro acoustic technology sensor assemblies and in communication with a surface distributed acoustic fiber optic interrogator.

Abstract: A timepiece including a case that houses a main plate of a movement surmounted by a dial, and a support including fastening studs arranged on an upper face of the main plate for mounting the dial. The dial and the support include an angular locking mechanism for locking an angular position of the dial on the support, and the dial is assembled to the main plate by at least one flexible fastening element integral with the dial and arranged in the plane of the dial.

Abstract: A method is described for enabling Raman Based Distributed Temperature Sensing (DTS) systems to operate over larger environmental temperature ranges than any systems available today.

Abstract: An example method includes obtaining a plurality of data items. Each data item includes an indication of a particular location, an indication that a wireless signal from a first access point was observed at that location, and an indication of a time at which the wireless signal from the first access point was observed at that location. The method also includes determining a locational stability of the first access point based on the data items. Determining the locational stability of the first access point includes clustering the plurality of data items into one or more clusters based on the locations indicated in the plurality of data items, determining whether the N most recent data items are associated with a common cluster, and determining whether a time span between the N most recent data items exceeds a threshold period of time.

Abstract: A system of translatable electro acoustic technology (EAT) modules for deployment along an oil or gas wellbore casing comprises: a wireline/slickline optical distributed acoustic sensing (DAS) cable deployed from the surface into the casing and connected to a surface interrogator; a tractor attached to the downhole end of the wireline/slickline optical distributed acoustic sensing (DAS) cable; and one or more EAT sensing modules that can be coupled to or decoupled from the wireline/slickline optical distributed acoustic sensing (DAS) cable at pre-selected locations and can either be coupled to or decoupled from the casing of the wellbore or be allowed to reposition along the wellborn casing, wherein the one or more EAT sensing modules can conduct multiple measurements and communicate the results via the wireline/slickline optical distributed acoustic sensing (DAS) cable to the surface interrogator.

Abstract: A cable introduction assembly that can include: a spool assembly including a spool having a first axis, the spool configured to retain a cable wound around the first axis in an undeployed mode; and a spool mount assembly configured to retain the spool and introduce the cable in a deployed mode into a conduit configured for a downhole environment, the conduit having a proximal end and a distal end, the cable in the deployed mode extending from the proximal end towards the distal end, wherein the spool assembly is configured to provide a handedness to the cable in the deployed mode.

Abstract: Concepts and technologies are described herein for transforming data to create layouts. In accordance with the concepts and technologies disclosed herein, a computing device can execute a layout generator. The computing device can be configured to receive or retrieve data that includes visual content such as an image and other content such as text. The computing device can analyze the visual content to identify a salient region and/or an invariant region within the visual content. The computing device can access designs for laying out visual content and other content based upon an identified salient region and/or invariant region. The computing device can evaluate the designs to determine if a design matches the data. The computing device can load the data into the selected design to generate the layout.

Abstract: The disclosure provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.

Abstract: A workflow engine processes a work problem to generate solutions for the work problem comprising a plurality of related optimization problems. The work problem may comprise a second optimization problem that is dependent on a first optimization problem, such that at least one solution for the first optimization problem is to be utilized as an initial solution for the second optimization problem. The workflow engine generates and stores a branch object for each optimization problem, each branch object specifying a solver engine assigned for processing the optimization problem and dependency information indicating a dependency relationship between the optimization problem and another optimization problem. The workflow engine processes the work problem based on the branch objects by initiating each solver engine to perform optimization operations on the assigned optimization problem based on the corresponding branch object to generate one or more solutions for the assigned optimization problem.

Abstract: A method includes receiving an indication that a patient is assigned to a patient device. The patient device stores healthcare information associated with the patient. The method includes sending configuration data to the patient device to configure the patient device to be compatible with a video conference service in response to receiving the indication that the patient is assigned to the patient device. The method includes generating video conference credentials for the patient in response to configuring the patient device. The video conference credentials enable an auto join link that is usable by a third party device to establish a video conference with the patient through the video conference service. The method includes sending the video conference credentials to the third party device.

Abstract: A guiding catheter has a proximal portion constructed of a tubular braid and a shape-retentive distal portion including a superelastic hypotube cut to define particular mating, support, shape-retentive and flexibility characteristics. A tubular liner extends through both of the tubular braid and the hypotube. The hypotube is joined to the braid using a mechanical interlock that has high torque transfer from the braid to the hypotube. A short portion of high stiffness polymer tube is provided at a joint between the braid and the hypotube. A polymeric outer jacket is provided over the proximal and distal portions, including the polymer tube. The jacket is heat set over the hypotube to remove residual stress.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: An atraumatic vessel occlusive system includes a flexible tubular member with an infusion lumen, a vessel occluder mounted at the distal end of the tubular member, and a pressure sensor located within a chamber defined by the occluder. The occluder has a braided construct provided with a fluid impermeable membrane over its proximal portion and a fluid permeable covering over its distal portion. The pressure sensor is adapted to sense pressure within the vessel through the fluid permeable membrane without being subject to the effects of turbulent flow at the exit of the infusion lumen. The accurately sensed pressure can be used to determine a dwell time for the occluder.

Abstract: Systems and methods for classifying content of an electronic file. One system includes an electronic processor configured to determine a content type associated with a portion of content included in the electronic file using a classification model developed using machine learning. The electronic processor is also configured to determine a suggested modification for the portion of content based on the determined content type. The suggested modification is a modification to a format property of the portion of content. The electronic processor is also configured to provide a notification of the suggested modification to a user for acceptance of the suggested modification. In response to the user accepting the suggested modification, the electronic processor is configured to modify the format property of the portion of content in accordance with the suggested modification.

Abstract: An online system receives multiple candidate components for including in content items to be presented to online system users. Upon identifying an opportunity to present content to a subject user of the online system, the online system dynamically generates an optimal content item for presentation to the subject user that includes one or more candidate components. Candidate components included in the optimal content item are selected by predicting an affinity of the subject user for each candidate component. The affinity of the subject user for a candidate component may be predicted using a machine-learned model that is trained using historical performance information about content items including the candidate component that were presented to viewing users of the online system having at least a threshold measure of similarity to the subject user. Components of content items used to train the model may be selected using a heuristic (e.g., Thompson sampling).

Abstract: An example method includes obtaining a plurality of data items. Each data item includes an indication of a particular location, an indication that a wireless signal from a first access point was observed at that location, and an indication of a time at which the wireless signal from the first access point was observed at that location. The method also includes determining a locational stability of the first access point based on the data items. Determining the locational stability of the first access point includes clustering the plurality of data items into one or more clusters based on the locations indicated in the plurality of data items, determining whether the N most recent data items are associated with a common cluster, and determining whether a time span between the N most recent data items exceeds a threshold period of time.

Abstract: The present disclosure provides methods for inhibiting intra and inter-cellular signaling pathways by modification of post-translation modification sites on select target RNA molecules. In certain example embodiments, the present disclosure provides methods for inhibiting intracellular phosphorylation of serine, threonine and tyrosine residues by editing the genetic codon of these amino acids by means of site-directed RNA editing or RNA molecules. Embodiments disclosed herein further provide methods of inhibiting pathological activation of cell signaling meditated by post-translational modifications, such as phosphorylation, which are involved in many diseases, including cancer, immunodeficiency, infectious diseases, inflammatory disorders and neurodegenerative disorders.

Abstract: A guiding catheter has a proximal portion constructed of a tubular braid and a shape-retentive distal portion including a superelastic hypotube cut to define particular mating, support, shape-retentive and flexibility characteristics. A tubular liner extends through both of the tubular braid and the hypotube. The hypotube is joined to the braid using a mechanical interlock that has high torque transfer from the braid to the hypotube. A short portion of high stiffness polymer tube is provided at a joint between the braid and the hypotube. A polymeric outer jacket is provided over the proximal and distal portions, including the polymer tube. The jacket is heat set over the hypotube to remove residual stress.

Abstract: Third-party publishers (such as websites) provide online advertisements combined with social endorsement information to users. A request for an advertisement is received from a viewing user via a third-party publisher system. A particular advertisement is selected in response to this request, and one or more advertisement tags associated with the advertisement are retrieved. The advertisement tags comprise information related to the advertisement. Social networking system data for users related to the viewing user is retrieved. Social endorsement information is obtained using the social networking system data and the advertisement tags associated with the advertisement. The social endorsement information and the advertisement are then combined and transmitted to the third-party publisher system, or are transmitted individually for combination by the third-party publisher system.

Abstract: Disclosed is a system and method for improving the performance of downhole Distributed Acoustic Sensing (DAS) systems by simultaneous use of co-propagating and counter-propagating Distributed Raman Amplification (DRA). It uses a surface DRA system with a surface DAS system to combine their laser sources where the distal end of the downhole sensing fiber use a Wavelength Division Multiplexer (WDM) to optically split the DRA and DAS signals onto two optical fibers. The DAS fiber/signal is terminated with a low reflectance termination to minimize a potential back reflection whereas the DRA fiber is terminated with a high reflectance termination causing all the light to reflect back up the sensing fiber. This arrangement allows for simultaneous co and counter-propagating DRA of the DAS signals, both the transmitted pulse and the back scattered light, thus creating the maximum amount of gain possible.