Abstract: The invention relates, in general, to synthetic chimeric poxviruses, compositions comprising such viruses, and the development and use of systems and methods for producing such synthetic chimeric poxviruses. The synthetic chimeric poxviruses are well suited for live virus vaccines and pharmaceutical formulations.

Abstract: Disclosed are compounds, compositions and methods for treating disease, syndromes, conditions and disorders that are affected by the modulation of MALT-1. Such compounds are represented by Formula (I) and Formula (II), wherein the variables are defined herein.

Abstract: A method and system for determining a variable rate treatment for a farming machine to autonomously apply to identified plants in a field is disclosed. The system applies a canopy recognition model to images captured for each region in the field. The model identifies each plant in the region and the plant's canopy, and then determines canopy characteristics based on the pixels of the image representing the plants in the plant canopy. Control signals for a variable rate treatment are determined based on these canopy characteristics. The treatment mechanism of the farming machine is then actuated using these control signals to apply the determined variable rate treatment to the plant.

Abstract: The invention relates, in general, to synthetic chimeric poxviruses, compositions comprising such viruses, and the development and use of systems and methods for producing such synthetic chimeric poxviruses. The synthetic chimeric poxviruses are well suited for live virus vaccines and pharmaceutical formulations.

Abstract: The invention relates in various aspects to a synthetic chimeric vaccinia virus or compositions comprising such viruses, and the development and use of systems and methods for producing such synthetic chimeric vaccinia viruses. The synthetic chimeric vaccinia viruses are well suited, among others, as virus vaccines or to generate an oncolytic response and pharmaceutical formulations.

Abstract: A pumpable crib bag assembly for forming a load-bearing support includes a containment bag arranged to be filled with a load-bearing material. The containment bag includes an upper end portion, a lower end portion, and a sidewall extending between the upper and lower end portions. The sidewall is configured to surround the load-bearing material within the containment bag to contain the load-bearing material therein. Aa reinforcing member extends along the sidewall to constrain the load-bearing material within the containment bag when a service load is applied to the assembly. The reinforcing member includes a flattened major surface arranged for contacting with the sidewall as the service load is applied to the assembly.

Abstract: Various embodiments provide systems, methods, devices, and instructions for protected data use in a third-party software application, where use can be enabled while maintaining protection of the protected data from the third party software application. In particular, various embodiments provide a software application architecture that permits a data party that owns or maintains protected data to support a software development ecosystem where a third-party can develop a third-party software application that uses the protected data while denying the third-party access to the protected data.

Abstract: The disclosed embodiments provide a version control system within a social networking environment. The disclosed embodiments perform operations comprising: storing, in a database, application data that is structured as a tree graph comprising nodes in the form of branches connected by respective edges, each child branch being connected to a single corresponding parent branch by a respective edge; generating a first checkpoint identifying a node of the tree graph, the first checkpoint comprising first checkpoint state information corresponding to initial state information of the node of the tree graph; generating a second checkpoint identifying the node of the tree graph, the second checkpoint comprising second checkpoint state information corresponding to the initial state information of the node of the tree graph; merging changes made to the first and second checkpoint state information; and modifying the initial state information of the node of the tree graph based on the merged changes.

Abstract: Various techniques for gesture-based community moderation are described, including activating a moderator application at a computing platform hosting a syndication of electronic messages, receiving a gesture configured to determine whether to present an electronic message at an interface, characterizing content of an electronic message to determine one or more attributes, analyzing characterized attributes of an electronic message to identify classification values representative of message attribute data, arranging the electronic messages relative to other electronic messages to form a queue of electronic messages as a function of message attribute data, receiving one or more gestures configured to cause presentation of a first electronic message, filtering the queue of the electronic messages with which to facilitate an action automatically of a first electronic message, and performing an automatic action in accordance with the first electronic message.

Abstract: Disclosed is a nucleic acid-polypeptide nano-pharmaceutical composition for treating and preventing human papilloma virus infection. A small interfering nucleic acid siRNA molecule used for inhibiting and treating various diseases caused by a HPV infection can block the virus replication life cycle by means of targeted inhibition of the expression of the HP16/18 key gene, reduce a viral infection and finally remove viruses. A pharmaceutical composition based on the siRNA molecule comprises a siRNA molecule and another molecule, including a siRNA molecule for inhibiting PD-1/PD-L1, a small molecule compound against a HPV infection, a therapeutic mRNA/neoantigen vaccine, and the like. The siRNA molecule and other anti-HPV drugs are coupled by means of a specific chemical bond to form a new coupled molecule, and the composition further includes a pharmaceutically acceptable polypeptide polymer nano-introduction carrier. In some embodiments, the carrier is a histidine-lysine polypeptide polymer nanocarrier.

Abstract: Various embodiments provide systems, methods, devices, and instructions for protected data use in a third-party software application, where use can be enabled while maintaining protection of the protected data from the third party software application. In particular, various embodiments provide a software application architecture that permits a data party that owns or maintains protected data to support a software development ecosystem where a third-party can develop a third-party software application that uses the protected data while denying the third-party access to the protected data.

Abstract: A systems and methods provided for generating a news article assisted by Artificial intelligence (AI), and a storage medium. The method comprises selecting input source material, obtaining the words and structured data of the information conveyed by each input source material selected, generating a writing model based on the information obtained, wherein AI assists the writing model to automatically create a news article. The writing model assisted by AI generates creative and accurate content by addressing the drawbacks related to (1) hallucinations, (2) extraneous data, (3) input structure constraints, (4) rewritten quotes, and (5) errant time references.

Abstract: The invention relates, in general, to synthetic chimeric poxviruses, compositions comprising such viruses, and the development and use of systems and methods for producing such synthetic chimeric poxviruses. The synthetic chimeric poxviruses are well suited for live virus vaccines and pharmaceutical formulations.

Abstract: A farming machine configured for identifying incorrectly configured plant identification models in farming machines is disclosed. The farming machine includes a control system configured to monitor the performance of a plant identification model to determine if it is appropriately configured for detecting plants in the field. To do so, the control system accesses images of plants in the field and applies a first plant identification model to the images to identify a probability plants in the images are a first class of plants. The control system applies a verification model to determine if plants in the field are the second class of plants (rather than the first) based on the determined probability. The farming machine applies a second plant identification model to the images to identify a second class of plants, and treats plants in the field identified as the second class of plant.

Abstract: A cyber threat defense system is provided comprising: a processing component; and a non-transitory computer readable medium including one or more software modules accessible by the processing component, the one or more software modules comprising: a vehicle module configured to receive data from a first vehicle and a second vehicle and reference one or more machine-learning models using machine-learning and artificial intelligence (AI) algorithms, the one or more machine-learning models including a first machine-learning model trained on a normal pattern of life associated with the first vehicle and the second vehicle, and a comparator module configured to cooperate with the vehicle module to compare data received from the first vehicle and the second vehicle to the normal pattern of life associated with the first vehicle and the second vehicle to detect anomalies representing a cyber threat within the first vehicle or the second vehicle.

Abstract: A system for inducing and sustaining an erection of a penis a vacuum assembly and a ring assembly adapted to encircle the penis. An inflatable ring assembly disposed in an outwardly flared proximal end of the tube. The ring assembly forms a central circular opening adapted for receiving the penis. A rigid annular ring support is disposed within the ring. A fluid pump is selectively coupled to a valve in the ring assembly, and the pump is adapted to introduce the bladder-inflating fluid under pressure. Expansion of the ring assembly causes the inner surface of the ring assembly to expand while being substantially fixed by the ring support against outwardly radial deformation. A compressive force is thus introduced around the surface of the penis for constricting blood flow from the penis sustain the erection.

Abstract: Various techniques for gesture-based community moderation are described, including activating a moderator application at a computing platform hosting a syndication of electronic messages, receiving a signal causing presentation of an electronic message at an interface, detecting an input associated with a position of each of the electronic messages on the interface and activating an automatic action by the moderator application, determining if a non-compliant message component is included in the each of the electronic messages, modifying each of the electronic messages if the non-compliant message component is detected, invoking a predicted automatic action based on the modified electronic message, and displaying the modified electronic message in a different position of the interface.

Abstract: Disclosed are compounds, compositions and methods for treating disease, syndromes, conditions and disorders that are affected by the modulation of MALT-1. Such compounds are represented by Formula (I) and Formula (II), wherein the variables are defined herein.

Abstract: An ophthalmic optical coherence tomography instrument, method, and computer-readable medium. The instrument includes a scanner defining an apparent point source for scanning sample light across a subject position and an objective having a posterior imaging configuration to project the apparent point source onto a pivot point between the objective and the subject position. The objective is settable between the posterior imaging configuration for scanning the sample light across a retina of an eye at the subject position and an anterior imaging configuration for scanning the sample light across a pivot plane. An axial region from which an interferogram is detectable extends across the pivot plane while the objective is in the anterior imaging configuration. A pupil alignment method uses the anterior imaging modality to obtain a structure position of a structure of an eye's anterior segment and then an offset between the structure position and a reference position.

Abstract: The present application relates to metal-organic frameworks (MOFs). More specifically, the present application relates to process for their preparation and uses thereof. The present application includes a process for preparing a chromium (III) phosphonate metal-organic framework (MOF) comprising: a) dehydrating a hydrogen-bonded metal-organic framework (HMOF) comprising chromium (III) hydrogen bonded to one or more organic polyphosphonate molecule by heating the HMOF at a controlled rate; b) cooling the dehydrated HMOF from a) to provide the MOF.