Abstract: A method of data storage includes determining a latency distance from a primary node to each of two or more replica nodes, choosing a preferred replica node of the two or more replica nodes based on the determined latency distances, and write-caching data into the preferred replica node.

Abstract: Compositions and methods are provided for the silencing of the BCLxL and MCL1 genes. Specifically, siRNA compositions are provided that contain siRNA molecules that target the BCLxL and MCL1 genes. Methods for using these compositions for treating cancer also are provided.

Abstract: An ophthalmic optical coherence tomography instrument, method, and computer-readable medium. The instrument includes a scanner defining an apparent point source for scanning sample light across a subject position and an objective having a posterior imaging configuration to project the apparent point source onto a pivot point between the objective and the subject position. The objective is settable between the posterior imaging configuration for scanning the sample light across a retina of an eye at the subject position and an anterior imaging configuration for scanning the sample light across a pivot plane. An axial region from which an interferogram is detectable extends across the pivot plane while the objective is in the anterior imaging configuration. A pupil alignment method uses the anterior imaging modality to obtain a structure position of a structure of an eye's anterior segment and then an offset between the structure position and a reference position.

Abstract: A leaf removal assembly including a frame comprising a front plate having a feed opening, a leaf stripping assembly mounted on said front plate in front of said feed opening and an upper sprocket wheel comprising a plurality of upper socket grippers extending radially outward of the upper sprocket wheel and being disposed behind the front plate. The leaf removal assembly further includes a lower sprocket wheel comprising a plurality of lower sprocket grippers extending radially outwardly of the lower sprocket wheel and being disposed behind the front plate. At least one of the upper sprocket wheel and the lower sprocket wheel may be adjustably attached to the frame. A process for separating a leaf from a stalk comprising at least one leaf is also included.

Abstract: Various techniques for gesture-based community moderation are described, including activating a moderator application at a computing platform hosting a syndication of electronic messages, receiving a signal causing presentation of an electronic message at an interface, detecting an input associated with a position of each of the electronic messages on the interface and activating an automatic action by the moderator application, determining if a non-compliant message component is included in the each of the electronic messages, modifying each of the electronic messages if the non-compliant message component is detected, invoking a predicted automatic action based on the modified electronic message, and displaying the modified electronic message in a different position of the interface.

Abstract: Four-wheel steering of a vehicle, e.g., in which leading wheels and trailing wheels are steered independently of each other, can provide improved maneuverability and stability. A first vehicle model may be used to determine trajectories for execution by a vehicle equipped with four-wheel steering. A second vehicle model may be used to control the vehicle relative to the determined trajectories. For instance, the second vehicle model can determine leading wheels steering angles for steering leading wheels of the vehicle and trailing wheels steering angles for steering trailing wheels of the vehicle, independently of the leading wheels.

Abstract: A system for humidifying respiratory gases has a humidification apparatus, a humidification chamber, a heating apparatus and a sensor. The sensor is configured to determine a characteristic of the gases flow and communicate this to a controller which controls the power supplied to the heating apparatus with respect to information regarding the characteristic of the gases flow. A structure partially encloses the humidification chamber and allows energy loss through a wall of the humidification chamber. The humidification chamber may have features to promote heat loss through the wall of the chamber.

Abstract: Examples are disclosed herein that relate to vehicles, composite parts, and methods for forming a composite part for a vehicle. In one example, a vehicle comprises a composite part comprising a skin comprising one or more material layers. The composite part further comprises a stiffener comprising one or more material layers, wherein the stiffener comprises a flange and a web. The composite part also includes an additively manufactured sub-structure positioned between at least a portion of the skin and at least a portion of the stiffener. The additively manufactured sub-structure comprises at least one flange portion, at least one radius, and at least one radius filler. A polymer matrix is co-infused within the skin, the stiffener, and the additively manufactured sub-structure.

Abstract: An apparatus, a method, a method of manufacturing an apparatus, and a method of constructing an integrated circuit are provided. A processor of an application server layer detects a degree of a change in a workload in an input/output stream received through a network from one or more user devices. The processor determines a degree range, from a plurality of preset degree ranges, that the degree of the change in the workload is within. The processor determines a distribution strategy, from among a plurality of distribution strategies, to distribute the workload across one or more of a plurality of solid state devices (SSDs) in a performance cache tier of a centralized multi-tier storage pool, based on the determined degree range. The processor distributes the workload across the one or more of the plurality of solid state devices based on the determined distribution strategy.

Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.

Abstract: In a method of producing symmetrical carbon fiber reinforced composite parts, a plurality of sheets of fibrous material configured as a single structure are positioned on a tool surface where the single structure is comprised of a first composite part joined to a symmetric, second composite part. The single structure is infused with resin and cured on the tool surface, producing a single cured structure comprised of a first cured composite part joined to a second cured composite part. The single cured structure is then divided along a dividing plane, producing the symmetric first cured composite part and second cured composite part.

Abstract: A combination of a chemical vapour deposition (CVD) coater and at least one capacitive proximity sensor, comprising: a CVD coater, and at least one capacitive proximity sensor attached to the CVD coater, wherein the at least one capacitive proximity sensor is arranged to determine the distance between a glass substrate and the CVD coater.

Abstract: Four-wheel steering of a vehicle, e.g., in which leading wheels and trailing wheels are steered independently of each other, can provide improved maneuverability and stability. A first vehicle model may be used to determine trajectories for execution by a vehicle equipped with four-wheel steering. A second vehicle model may be used to control the vehicle relative to the determined trajectories. For instance, the second vehicle model can determine leading wheels steering angles for steering leading wheels of the vehicle and trailing wheels steering angles for steering trailing wheels of the vehicle, independently of the leading wheels.

Abstract: The invention relates, in general, to synthetic chimeric poxviruses, compositions comprising such viruses, and the development and use of systems and methods for producing such synthetic chimeric poxviruses. The synthetic chimeric poxviruses are well suited for live virus vaccines and pharmaceutical formulations.

Abstract: Various techniques for gesture-based community moderation are described, including activating a moderator application at a computing platform hosting a syndication of electronic messages, receiving a signal causing presentation of an electronic message at an interface, detecting an input associated with a position of each of the electronic messages on the interface and activating an automatic action by the moderator application, determining if a non-compliant message component is included in the each of the electronic messages, modifying each of the electronic messages if the non-compliant message component is detected, invoking a predicted automatic action based on the modified electronic message, and displaying the modified electronic message in a different position of the interface.

Abstract: The present invention relates to compositions and methods for siRNA therapeutics for prevention and treatment of Middle East Respiratory Syndrome Corona Virus (MERS-CoA) infections. The compositions include a pharmaceutical composition comprising siRNA cocktails that target viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers.

Abstract: An apparatus includes channel assemblies in a rotatable section, a cutting assembly, a discharge assembly, and a cleanout assembly. The channel assembly holds a bulk instance of compressible material extending through upper and lower channels of a continuous channel. The cutting assembly moves in relation to the channel assembly to isolate the upper and lower channels, severing upper and lower material portions of the bulk instance. The discharge assembly directs gas into the lower channel of a channel assembly to discharge the lower material portion from the lower channel, based on radial alignment of a conduit assembly of the channel assembly with a conduit assembly of the discharge assembly. The cleanout assembly supplies a fluid through the conduit assembly of the channel assembly, based on radially alignment of the conduit assembly of the channel assembly with a conduit assembly of the cleanout assembly.

Abstract: A system for humidifying respiratory gases has a humidification apparatus, a humidification chamber, a heating apparatus and a sensor. The sensor is configured to determine a characteristic of the gases flow and communicate this to a controller which controls the power supplied to the heating apparatus with respect to information regarding the characteristic of the gases flow. A structure partially encloses the humidification chamber and allows energy loss through a wall of the humidification chamber. The humidification chamber may have features to promote heat loss through the wall of the chamber.

Abstract: An apparatus configured to provide portioned instances of a compressible material includes a channel assembly, a gas source, a cutting assembly, and a discharge assembly. The channel assembly holds a bulk instance of the material extending through upper and lower channels of a continuous channel. The gas source supplies gas to compress the bulk instance. The cutting assembly moves in relation to the channel assembly to isolate the upper and lower channels, severing upper and lower material portions of the bulk instance. The discharge assembly directs gas to impinge on a lower face of the cutting assembly to discharge the lower material portion as a portioned instance. The channel assembly may be moveable, where operation of the gas source, cutting assembly, and/or discharge assembly are based on moving the channel assembly between various positions. The gas supply may be controlled based on a determined property of the portioned instance.

Abstract: A load balancing system includes: a centralized queue; a pool of resource nodes connected to the centralized queue; one or more processors; and memory coupled to the one or more processors and storing instructions that, when executed by the one or more processors, cause the one or more processors to: monitor a queue status of the centralized queue to identify a bursty traffic period; calculate an index value for a load associated with the bursty traffic period; select a load balancing strategy based on the index value; distribute the load to the pool of resource nodes based on the load balancing strategy; observe a state of the pool of resource nodes in response to the load balancing strategy; calculate a reward based on the observed state; and adjust the load balancing strategy based on the reward.